Cargando…
Chronic Consumption of Fructose Induces Behavioral Alterations by Increasing Orexin and Dopamine Levels in the Rat Brain
It has been widely described that chronic intake of fructose causes metabolic alterations which can be associated with brain function impairment. In this study, we evaluated the effects of fructose intake on the sleep–wake cycle, locomotion, and neurochemical parameters in Wistar rats. The experimen...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265759/ https://www.ncbi.nlm.nih.gov/pubmed/30423806 http://dx.doi.org/10.3390/nu10111722 |
_version_ | 1783375692245762048 |
---|---|
author | Franco-Pérez, Javier Manjarrez-Marmolejo, Joaquín Ballesteros-Zebadúa, Paola Neri-Santos, Adriana Montes, Sergio Suarez-Rivera, Norma Hernández-Cerón, Miguel Pérez-Koldenkova, Vadim |
author_facet | Franco-Pérez, Javier Manjarrez-Marmolejo, Joaquín Ballesteros-Zebadúa, Paola Neri-Santos, Adriana Montes, Sergio Suarez-Rivera, Norma Hernández-Cerón, Miguel Pérez-Koldenkova, Vadim |
author_sort | Franco-Pérez, Javier |
collection | PubMed |
description | It has been widely described that chronic intake of fructose causes metabolic alterations which can be associated with brain function impairment. In this study, we evaluated the effects of fructose intake on the sleep–wake cycle, locomotion, and neurochemical parameters in Wistar rats. The experimental group was fed with 10% fructose in drinking water for five weeks. After treatment, metabolic indicators were quantified in blood. Electroencephalographic recordings were used to evaluate the sleep architecture and the spectral power of frequency bands. Likewise, the locomotor activity and the concentrations of orexin A and monoamines were estimated. Our results show that fructose diet significantly increased the blood levels of glucose, cholesterol, and triglycerides. Fructose modified the sleep–wake cycle of rats, increasing the waking duration and conversely decreasing the non-rapid eye movement sleep. Furthermore, these effects were accompanied by increases of the spectral power at different frequency bands. Chronic consumption of fructose caused a slight increase in the locomotor activity as well as an increase of orexin A and dopamine levels in the hypothalamus and brainstem. Specifically, immunoreactivity for orexin A was increased in the ventral tegmental area after the intake of fructose. Our study suggests that fructose induces metabolic changes and stimulates the activity of orexinergic and dopaminergic neurons, which may be responsible for alterations of the sleep–wake cycle. |
format | Online Article Text |
id | pubmed-6265759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62657592018-12-06 Chronic Consumption of Fructose Induces Behavioral Alterations by Increasing Orexin and Dopamine Levels in the Rat Brain Franco-Pérez, Javier Manjarrez-Marmolejo, Joaquín Ballesteros-Zebadúa, Paola Neri-Santos, Adriana Montes, Sergio Suarez-Rivera, Norma Hernández-Cerón, Miguel Pérez-Koldenkova, Vadim Nutrients Article It has been widely described that chronic intake of fructose causes metabolic alterations which can be associated with brain function impairment. In this study, we evaluated the effects of fructose intake on the sleep–wake cycle, locomotion, and neurochemical parameters in Wistar rats. The experimental group was fed with 10% fructose in drinking water for five weeks. After treatment, metabolic indicators were quantified in blood. Electroencephalographic recordings were used to evaluate the sleep architecture and the spectral power of frequency bands. Likewise, the locomotor activity and the concentrations of orexin A and monoamines were estimated. Our results show that fructose diet significantly increased the blood levels of glucose, cholesterol, and triglycerides. Fructose modified the sleep–wake cycle of rats, increasing the waking duration and conversely decreasing the non-rapid eye movement sleep. Furthermore, these effects were accompanied by increases of the spectral power at different frequency bands. Chronic consumption of fructose caused a slight increase in the locomotor activity as well as an increase of orexin A and dopamine levels in the hypothalamus and brainstem. Specifically, immunoreactivity for orexin A was increased in the ventral tegmental area after the intake of fructose. Our study suggests that fructose induces metabolic changes and stimulates the activity of orexinergic and dopaminergic neurons, which may be responsible for alterations of the sleep–wake cycle. MDPI 2018-11-10 /pmc/articles/PMC6265759/ /pubmed/30423806 http://dx.doi.org/10.3390/nu10111722 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Franco-Pérez, Javier Manjarrez-Marmolejo, Joaquín Ballesteros-Zebadúa, Paola Neri-Santos, Adriana Montes, Sergio Suarez-Rivera, Norma Hernández-Cerón, Miguel Pérez-Koldenkova, Vadim Chronic Consumption of Fructose Induces Behavioral Alterations by Increasing Orexin and Dopamine Levels in the Rat Brain |
title | Chronic Consumption of Fructose Induces Behavioral Alterations by Increasing Orexin and Dopamine Levels in the Rat Brain |
title_full | Chronic Consumption of Fructose Induces Behavioral Alterations by Increasing Orexin and Dopamine Levels in the Rat Brain |
title_fullStr | Chronic Consumption of Fructose Induces Behavioral Alterations by Increasing Orexin and Dopamine Levels in the Rat Brain |
title_full_unstemmed | Chronic Consumption of Fructose Induces Behavioral Alterations by Increasing Orexin and Dopamine Levels in the Rat Brain |
title_short | Chronic Consumption of Fructose Induces Behavioral Alterations by Increasing Orexin and Dopamine Levels in the Rat Brain |
title_sort | chronic consumption of fructose induces behavioral alterations by increasing orexin and dopamine levels in the rat brain |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265759/ https://www.ncbi.nlm.nih.gov/pubmed/30423806 http://dx.doi.org/10.3390/nu10111722 |
work_keys_str_mv | AT francoperezjavier chronicconsumptionoffructoseinducesbehavioralalterationsbyincreasingorexinanddopaminelevelsintheratbrain AT manjarrezmarmolejojoaquin chronicconsumptionoffructoseinducesbehavioralalterationsbyincreasingorexinanddopaminelevelsintheratbrain AT ballesteroszebaduapaola chronicconsumptionoffructoseinducesbehavioralalterationsbyincreasingorexinanddopaminelevelsintheratbrain AT nerisantosadriana chronicconsumptionoffructoseinducesbehavioralalterationsbyincreasingorexinanddopaminelevelsintheratbrain AT montessergio chronicconsumptionoffructoseinducesbehavioralalterationsbyincreasingorexinanddopaminelevelsintheratbrain AT suarezriveranorma chronicconsumptionoffructoseinducesbehavioralalterationsbyincreasingorexinanddopaminelevelsintheratbrain AT hernandezceronmiguel chronicconsumptionoffructoseinducesbehavioralalterationsbyincreasingorexinanddopaminelevelsintheratbrain AT perezkoldenkovavadim chronicconsumptionoffructoseinducesbehavioralalterationsbyincreasingorexinanddopaminelevelsintheratbrain |