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Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents

This study aimed to estimate the exposure and related health risks of phthalates, and to assess the health risks from combined exposure to three of the phthalates sharing the same mode of action (anti-androgenicity) in children. We determined the internal exposure of 56 Iranian children and adolesce...

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Autores principales: Zare Jeddi, Maryam, Eshaghi Gorji, Mohamad, Rietjens, Ivonne M. C. M., Louisse, Jochem, Bruinen de Bruin, Yuri, Liska, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265767/
https://www.ncbi.nlm.nih.gov/pubmed/30360526
http://dx.doi.org/10.3390/ijerph15112336
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author Zare Jeddi, Maryam
Eshaghi Gorji, Mohamad
Rietjens, Ivonne M. C. M.
Louisse, Jochem
Bruinen de Bruin, Yuri
Liska, Roman
author_facet Zare Jeddi, Maryam
Eshaghi Gorji, Mohamad
Rietjens, Ivonne M. C. M.
Louisse, Jochem
Bruinen de Bruin, Yuri
Liska, Roman
author_sort Zare Jeddi, Maryam
collection PubMed
description This study aimed to estimate the exposure and related health risks of phthalates, and to assess the health risks from combined exposure to three of the phthalates sharing the same mode of action (anti-androgenicity) in children. We determined the internal exposure of 56 Iranian children and adolescents aged 6 to 18 years by analyzing seven urinary metabolites of five phthalates. The estimated daily intake values derived from the biomonitoring data ranged from 0.01 µg/kg bw/day for butyl benzyl phthalate (BBP), to 17.85 µg/kg bw/day for di(2-ethylhexyl) phthalate (DEHP). The risk assessment revealed that not only the exposure to the individual phthalates, but also the combined exposure to the three anti-androgenic phthalates (DEHP, DBP, BBP) did not raise a safety concern (hazard index values averaged 0.2). The range of maximum cumulative ratio values varied from around 1 for most individuals to around 2 in some individuals, indicating that the combined exposures were dominated by one and in some cases by two of the three anti-androgenic phthalates, especially dibutyl phthalate (DBP) and/or DEHP. Based on biomonitoring data, the overall combined exposure of Iranian children to phthalates does not raise a concern, while reduction of exposure is best focused on DEHP and DBP that showed the highest hazard quotient.
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spelling pubmed-62657672018-12-15 Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents Zare Jeddi, Maryam Eshaghi Gorji, Mohamad Rietjens, Ivonne M. C. M. Louisse, Jochem Bruinen de Bruin, Yuri Liska, Roman Int J Environ Res Public Health Article This study aimed to estimate the exposure and related health risks of phthalates, and to assess the health risks from combined exposure to three of the phthalates sharing the same mode of action (anti-androgenicity) in children. We determined the internal exposure of 56 Iranian children and adolescents aged 6 to 18 years by analyzing seven urinary metabolites of five phthalates. The estimated daily intake values derived from the biomonitoring data ranged from 0.01 µg/kg bw/day for butyl benzyl phthalate (BBP), to 17.85 µg/kg bw/day for di(2-ethylhexyl) phthalate (DEHP). The risk assessment revealed that not only the exposure to the individual phthalates, but also the combined exposure to the three anti-androgenic phthalates (DEHP, DBP, BBP) did not raise a safety concern (hazard index values averaged 0.2). The range of maximum cumulative ratio values varied from around 1 for most individuals to around 2 in some individuals, indicating that the combined exposures were dominated by one and in some cases by two of the three anti-androgenic phthalates, especially dibutyl phthalate (DBP) and/or DEHP. Based on biomonitoring data, the overall combined exposure of Iranian children to phthalates does not raise a concern, while reduction of exposure is best focused on DEHP and DBP that showed the highest hazard quotient. MDPI 2018-10-23 2018-11 /pmc/articles/PMC6265767/ /pubmed/30360526 http://dx.doi.org/10.3390/ijerph15112336 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zare Jeddi, Maryam
Eshaghi Gorji, Mohamad
Rietjens, Ivonne M. C. M.
Louisse, Jochem
Bruinen de Bruin, Yuri
Liska, Roman
Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents
title Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents
title_full Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents
title_fullStr Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents
title_full_unstemmed Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents
title_short Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents
title_sort biomonitoring and subsequent risk assessment of combined exposure to phthalates in iranian children and adolescents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265767/
https://www.ncbi.nlm.nih.gov/pubmed/30360526
http://dx.doi.org/10.3390/ijerph15112336
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