Acylated Aminooligosaccharides with Inhibitory Effects against α-Amylase from Streptomyces sp. HO1518

Five new acylated aminooligosaccharides (1–5), together with one known related analogue (6), were isolated from Streptomyces sp. HO1518. Their structure was identified by extensive spectroscopic analysis, including 1D and 2D NMR data and high resolution electrospray ionization mass spectrometry (HRE...

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Autores principales: Liu, Hai-Li, E, Heng-Chao, Xie, Ding-An, Cheng, Wen-Bo, Tao, Wan-Qi, Wang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265919/
https://www.ncbi.nlm.nih.gov/pubmed/30360574
http://dx.doi.org/10.3390/md16110403
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author Liu, Hai-Li
E, Heng-Chao
Xie, Ding-An
Cheng, Wen-Bo
Tao, Wan-Qi
Wang, Yong
author_facet Liu, Hai-Li
E, Heng-Chao
Xie, Ding-An
Cheng, Wen-Bo
Tao, Wan-Qi
Wang, Yong
author_sort Liu, Hai-Li
collection PubMed
description Five new acylated aminooligosaccharides (1–5), together with one known related analogue (6), were isolated from Streptomyces sp. HO1518. Their structure was identified by extensive spectroscopic analysis, including 1D and 2D NMR data and high resolution electrospray ionization mass spectrometry (HRESIMS), and by comparison with those reported in the literature. All of the new compounds showed more promising porcine pancreatic α-amylase (PPA) inhibitory activities than the clinical drug acarbose, indicating them as potential pharmaceutical drug leads toward type II diabetes.
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spelling pubmed-62659192018-12-06 Acylated Aminooligosaccharides with Inhibitory Effects against α-Amylase from Streptomyces sp. HO1518 Liu, Hai-Li E, Heng-Chao Xie, Ding-An Cheng, Wen-Bo Tao, Wan-Qi Wang, Yong Mar Drugs Article Five new acylated aminooligosaccharides (1–5), together with one known related analogue (6), were isolated from Streptomyces sp. HO1518. Their structure was identified by extensive spectroscopic analysis, including 1D and 2D NMR data and high resolution electrospray ionization mass spectrometry (HRESIMS), and by comparison with those reported in the literature. All of the new compounds showed more promising porcine pancreatic α-amylase (PPA) inhibitory activities than the clinical drug acarbose, indicating them as potential pharmaceutical drug leads toward type II diabetes. MDPI 2018-10-23 /pmc/articles/PMC6265919/ /pubmed/30360574 http://dx.doi.org/10.3390/md16110403 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Hai-Li
E, Heng-Chao
Xie, Ding-An
Cheng, Wen-Bo
Tao, Wan-Qi
Wang, Yong
Acylated Aminooligosaccharides with Inhibitory Effects against α-Amylase from Streptomyces sp. HO1518
title Acylated Aminooligosaccharides with Inhibitory Effects against α-Amylase from Streptomyces sp. HO1518
title_full Acylated Aminooligosaccharides with Inhibitory Effects against α-Amylase from Streptomyces sp. HO1518
title_fullStr Acylated Aminooligosaccharides with Inhibitory Effects against α-Amylase from Streptomyces sp. HO1518
title_full_unstemmed Acylated Aminooligosaccharides with Inhibitory Effects against α-Amylase from Streptomyces sp. HO1518
title_short Acylated Aminooligosaccharides with Inhibitory Effects against α-Amylase from Streptomyces sp. HO1518
title_sort acylated aminooligosaccharides with inhibitory effects against α-amylase from streptomyces sp. ho1518
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265919/
https://www.ncbi.nlm.nih.gov/pubmed/30360574
http://dx.doi.org/10.3390/md16110403
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