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Delayed LY333013 (Oral) and LY315920 (Intravenous) Reverse Severe Neurotoxicity and Rescue Juvenile Pigs from Lethal Doses of Micrurus fulvius (Eastern Coral Snake) Venom
There is a clear, unmet need for effective, lightweight, shelf-stable and economical snakebite envenoming therapies that can be given rapidly after the time of a snake’s bite and as adjuncts to antivenom therapies in the hospital setting. The sPLA2 inhibitor, LY315920, and its orally bioavailable pr...
Autores principales: | Lewin, Matthew R., Gilliam, Lyndi L., Gilliam, John, Samuel, Stephen P., Bulfone, Tommaso C., Bickler, Philip E., Gutiérrez, José María |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265968/ https://www.ncbi.nlm.nih.gov/pubmed/30453607 http://dx.doi.org/10.3390/toxins10110479 |
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