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Brain Mapping as Helpful Tool in Brain Glioma Surgical Treatment—Toward the “Perfect Surgery”?

Gliomas are the most common primary malignant brain tumours in adults, representing nearly 80%, with poor prognosis in their high-grade forms. Several variables positively affect the prognosis of patients with high-grade glioma: young age, tumour location, radiological features, recurrence, and the...

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Autores principales: Barone, Fabio, Alberio, Nicola, Iacopino, Domenico Gerardo, Giammalva, Giuseppe Roberto, D’Arrigo, Corrado, Tagnese, Walter, Graziano, Francesca, Cicero, Salvatore, Maugeri, Rosario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266076/
https://www.ncbi.nlm.nih.gov/pubmed/30373168
http://dx.doi.org/10.3390/brainsci8110192
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author Barone, Fabio
Alberio, Nicola
Iacopino, Domenico Gerardo
Giammalva, Giuseppe Roberto
D’Arrigo, Corrado
Tagnese, Walter
Graziano, Francesca
Cicero, Salvatore
Maugeri, Rosario
author_facet Barone, Fabio
Alberio, Nicola
Iacopino, Domenico Gerardo
Giammalva, Giuseppe Roberto
D’Arrigo, Corrado
Tagnese, Walter
Graziano, Francesca
Cicero, Salvatore
Maugeri, Rosario
author_sort Barone, Fabio
collection PubMed
description Gliomas are the most common primary malignant brain tumours in adults, representing nearly 80%, with poor prognosis in their high-grade forms. Several variables positively affect the prognosis of patients with high-grade glioma: young age, tumour location, radiological features, recurrence, and the opportunity to perform post-operative adjuvant therapy. Low-grade gliomas are slow-growing brain neoplasms of adolescence and young-adulthood, preferentially involving functional areas, particularly the eloquent ones. It has been demonstrated that early surgery and higher extent rate ensure overall longer survival time regardless of tumour grading, but nowadays, functional preservation that is as complete as possible is imperative. To achieve the best surgical results, along with the best functional results, intraoperative mapping and monitoring of brain functions, as well as different anaesthesiology protocols for awake surgery are nowadays being widely adopted. We report on our experience at our institution with 28 patients affected by malignant brain tumours who underwent brain mapping-aided surgical resection of neoplasm: 20 patients underwent awake surgical resection and 8 patients underwent asleep surgical resection. An analysis of the results and a review of the literature has been performed.
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spelling pubmed-62660762018-12-03 Brain Mapping as Helpful Tool in Brain Glioma Surgical Treatment—Toward the “Perfect Surgery”? Barone, Fabio Alberio, Nicola Iacopino, Domenico Gerardo Giammalva, Giuseppe Roberto D’Arrigo, Corrado Tagnese, Walter Graziano, Francesca Cicero, Salvatore Maugeri, Rosario Brain Sci Article Gliomas are the most common primary malignant brain tumours in adults, representing nearly 80%, with poor prognosis in their high-grade forms. Several variables positively affect the prognosis of patients with high-grade glioma: young age, tumour location, radiological features, recurrence, and the opportunity to perform post-operative adjuvant therapy. Low-grade gliomas are slow-growing brain neoplasms of adolescence and young-adulthood, preferentially involving functional areas, particularly the eloquent ones. It has been demonstrated that early surgery and higher extent rate ensure overall longer survival time regardless of tumour grading, but nowadays, functional preservation that is as complete as possible is imperative. To achieve the best surgical results, along with the best functional results, intraoperative mapping and monitoring of brain functions, as well as different anaesthesiology protocols for awake surgery are nowadays being widely adopted. We report on our experience at our institution with 28 patients affected by malignant brain tumours who underwent brain mapping-aided surgical resection of neoplasm: 20 patients underwent awake surgical resection and 8 patients underwent asleep surgical resection. An analysis of the results and a review of the literature has been performed. MDPI 2018-10-26 /pmc/articles/PMC6266076/ /pubmed/30373168 http://dx.doi.org/10.3390/brainsci8110192 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Barone, Fabio
Alberio, Nicola
Iacopino, Domenico Gerardo
Giammalva, Giuseppe Roberto
D’Arrigo, Corrado
Tagnese, Walter
Graziano, Francesca
Cicero, Salvatore
Maugeri, Rosario
Brain Mapping as Helpful Tool in Brain Glioma Surgical Treatment—Toward the “Perfect Surgery”?
title Brain Mapping as Helpful Tool in Brain Glioma Surgical Treatment—Toward the “Perfect Surgery”?
title_full Brain Mapping as Helpful Tool in Brain Glioma Surgical Treatment—Toward the “Perfect Surgery”?
title_fullStr Brain Mapping as Helpful Tool in Brain Glioma Surgical Treatment—Toward the “Perfect Surgery”?
title_full_unstemmed Brain Mapping as Helpful Tool in Brain Glioma Surgical Treatment—Toward the “Perfect Surgery”?
title_short Brain Mapping as Helpful Tool in Brain Glioma Surgical Treatment—Toward the “Perfect Surgery”?
title_sort brain mapping as helpful tool in brain glioma surgical treatment—toward the “perfect surgery”?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266076/
https://www.ncbi.nlm.nih.gov/pubmed/30373168
http://dx.doi.org/10.3390/brainsci8110192
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