Spectrum and Prevalence of Pathogenic Variants in Ovarian Cancer Susceptibility Genes in a Group of 333 Patients

Constitutional loss-of-function pathogenic variants in the tumor suppressor genes BRCA1 and BRCA2 are widely associated with an elevated risk of ovarian cancer (OC). As only ~15% of OC individuals carry the BRCA1/2 pathogenic variants, the identification of other potential OC-susceptibility genes is...

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Detalles Bibliográficos
Autores principales: Koczkowska, Magdalena, Krawczynska, Natalia, Stukan, Maciej, Kuzniacka, Alina, Brozek, Izabela, Sniadecki, Marcin, Debniak, Jaroslaw, Wydra, Dariusz, Biernat, Wojciech, Kozlowski, Piotr, Limon, Janusz, Wasag, Bartosz, Ratajska, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266089/
https://www.ncbi.nlm.nih.gov/pubmed/30441849
http://dx.doi.org/10.3390/cancers10110442

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