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Associations among High-Quality Protein and Energy Intake, Serum Transthyretin, Serum Amino Acids and Linear Growth of Children in Ethiopia

Limited evidence is available on the associations of high-quality protein and energy intake, serum transthyretin (TTR), serum amino acids and serum insulin-like growth factor-1 (IGF-1) with linear growth of young children. Data collected during the baseline of a randomized control trial involving ru...

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Autores principales: Tessema, Masresha, Gunaratna, Nilupa S., Brouwer, Inge D., Donato, Katherine, Cohen, Jessica L., McConnell, Margaret, Belachew, Tefera, Belayneh, Demissie, De Groote, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266228/
https://www.ncbi.nlm.nih.gov/pubmed/30453477
http://dx.doi.org/10.3390/nu10111776
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author Tessema, Masresha
Gunaratna, Nilupa S.
Brouwer, Inge D.
Donato, Katherine
Cohen, Jessica L.
McConnell, Margaret
Belachew, Tefera
Belayneh, Demissie
De Groote, Hugo
author_facet Tessema, Masresha
Gunaratna, Nilupa S.
Brouwer, Inge D.
Donato, Katherine
Cohen, Jessica L.
McConnell, Margaret
Belachew, Tefera
Belayneh, Demissie
De Groote, Hugo
author_sort Tessema, Masresha
collection PubMed
description Limited evidence is available on the associations of high-quality protein and energy intake, serum transthyretin (TTR), serum amino acids and serum insulin-like growth factor-1 (IGF-1) with linear growth of young children. Data collected during the baseline of a randomized control trial involving rural Ethiopian children aged 6–35 months (n = 873) were analyzed to evaluate the associations among height/length-for-age z-scores, dietary intakes, and these biomarkers (i.e., serum level of TTR, IGF-1, tryptophan and lysine, and inflammation). The prevalence of stunting was higher for children >23 months (38%) than ≤23 months (25%). The prevalence of inflammation was 35% and of intestinal parasites 48%. Three-quarters of the children were energy deficient, and stunted children had lower daily energy intake that non-stunted children (p < 0.05). Intakes of tryptophan, protein, and energy, and serum levels of tryptophan and IGF-1 were positively correlated with the linear growth of children. Controlling for inflammation, intestinal parasites, and sociodemographic characteristics, daily tryptophan (b = 0.01, p = 0.001), protein (b = 0.01, p = 0.01) and energy (b = 0.0003, p = 0.04) intakes and serum TTR (b = 2.58, p = 0.04) and IGF-1 (b = 0.01, p = 0.003) were positively associated with linear growth of children. Linear growth failure in Ethiopian children is likely associated with low quality protein intake and inadequate energy intake. Nutrition programs that emphasize improved protein quantity and quality and energy intake may enhance the linear growth of young children and need to be further investigated in longitudinal and interventional studies.
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spelling pubmed-62662282018-12-06 Associations among High-Quality Protein and Energy Intake, Serum Transthyretin, Serum Amino Acids and Linear Growth of Children in Ethiopia Tessema, Masresha Gunaratna, Nilupa S. Brouwer, Inge D. Donato, Katherine Cohen, Jessica L. McConnell, Margaret Belachew, Tefera Belayneh, Demissie De Groote, Hugo Nutrients Article Limited evidence is available on the associations of high-quality protein and energy intake, serum transthyretin (TTR), serum amino acids and serum insulin-like growth factor-1 (IGF-1) with linear growth of young children. Data collected during the baseline of a randomized control trial involving rural Ethiopian children aged 6–35 months (n = 873) were analyzed to evaluate the associations among height/length-for-age z-scores, dietary intakes, and these biomarkers (i.e., serum level of TTR, IGF-1, tryptophan and lysine, and inflammation). The prevalence of stunting was higher for children >23 months (38%) than ≤23 months (25%). The prevalence of inflammation was 35% and of intestinal parasites 48%. Three-quarters of the children were energy deficient, and stunted children had lower daily energy intake that non-stunted children (p < 0.05). Intakes of tryptophan, protein, and energy, and serum levels of tryptophan and IGF-1 were positively correlated with the linear growth of children. Controlling for inflammation, intestinal parasites, and sociodemographic characteristics, daily tryptophan (b = 0.01, p = 0.001), protein (b = 0.01, p = 0.01) and energy (b = 0.0003, p = 0.04) intakes and serum TTR (b = 2.58, p = 0.04) and IGF-1 (b = 0.01, p = 0.003) were positively associated with linear growth of children. Linear growth failure in Ethiopian children is likely associated with low quality protein intake and inadequate energy intake. Nutrition programs that emphasize improved protein quantity and quality and energy intake may enhance the linear growth of young children and need to be further investigated in longitudinal and interventional studies. MDPI 2018-11-16 /pmc/articles/PMC6266228/ /pubmed/30453477 http://dx.doi.org/10.3390/nu10111776 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tessema, Masresha
Gunaratna, Nilupa S.
Brouwer, Inge D.
Donato, Katherine
Cohen, Jessica L.
McConnell, Margaret
Belachew, Tefera
Belayneh, Demissie
De Groote, Hugo
Associations among High-Quality Protein and Energy Intake, Serum Transthyretin, Serum Amino Acids and Linear Growth of Children in Ethiopia
title Associations among High-Quality Protein and Energy Intake, Serum Transthyretin, Serum Amino Acids and Linear Growth of Children in Ethiopia
title_full Associations among High-Quality Protein and Energy Intake, Serum Transthyretin, Serum Amino Acids and Linear Growth of Children in Ethiopia
title_fullStr Associations among High-Quality Protein and Energy Intake, Serum Transthyretin, Serum Amino Acids and Linear Growth of Children in Ethiopia
title_full_unstemmed Associations among High-Quality Protein and Energy Intake, Serum Transthyretin, Serum Amino Acids and Linear Growth of Children in Ethiopia
title_short Associations among High-Quality Protein and Energy Intake, Serum Transthyretin, Serum Amino Acids and Linear Growth of Children in Ethiopia
title_sort associations among high-quality protein and energy intake, serum transthyretin, serum amino acids and linear growth of children in ethiopia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266228/
https://www.ncbi.nlm.nih.gov/pubmed/30453477
http://dx.doi.org/10.3390/nu10111776
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