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Novel Variable Radius Spiral–Shaped Micromixer: From Numerical Analysis to Experimental Validation
A novel type of spiral micromixer with expansion and contraction parts is presented in order to enhance the mixing quality in the low Reynolds number regimes for point-of-care tests (POCT). Three classes of micromixers with different numbers of loops and modified geometries were studied. Numerical s...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266334/ https://www.ncbi.nlm.nih.gov/pubmed/30715051 http://dx.doi.org/10.3390/mi9110552 |
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author | Mehrdel, Pouya Karimi, Shadi Farré-Lladós, Josep Casals-Terré, Jasmina |
author_facet | Mehrdel, Pouya Karimi, Shadi Farré-Lladós, Josep Casals-Terré, Jasmina |
author_sort | Mehrdel, Pouya |
collection | PubMed |
description | A novel type of spiral micromixer with expansion and contraction parts is presented in order to enhance the mixing quality in the low Reynolds number regimes for point-of-care tests (POCT). Three classes of micromixers with different numbers of loops and modified geometries were studied. Numerical simulation was performed to study the flow behavior and mixing performance solving the steady-state Navier–Stokes and the convection-diffusion equations in the Reynolds range of 0.1–10.0. Comparisons between the mixers with and without expansion parts were made to illustrate the effect of disturbing the streamlines on the mixing performance. Image analysis of the mixing results from fabricated micromixers was used to verify the results of the simulations. Since the proposed mixer provides up to 92% of homogeneity at Re 1.0, generating 442 Pa of pressure drop, this mixer makes a suitable candidate for research in the POCT field. |
format | Online Article Text |
id | pubmed-6266334 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62663342018-12-06 Novel Variable Radius Spiral–Shaped Micromixer: From Numerical Analysis to Experimental Validation Mehrdel, Pouya Karimi, Shadi Farré-Lladós, Josep Casals-Terré, Jasmina Micromachines (Basel) Article A novel type of spiral micromixer with expansion and contraction parts is presented in order to enhance the mixing quality in the low Reynolds number regimes for point-of-care tests (POCT). Three classes of micromixers with different numbers of loops and modified geometries were studied. Numerical simulation was performed to study the flow behavior and mixing performance solving the steady-state Navier–Stokes and the convection-diffusion equations in the Reynolds range of 0.1–10.0. Comparisons between the mixers with and without expansion parts were made to illustrate the effect of disturbing the streamlines on the mixing performance. Image analysis of the mixing results from fabricated micromixers was used to verify the results of the simulations. Since the proposed mixer provides up to 92% of homogeneity at Re 1.0, generating 442 Pa of pressure drop, this mixer makes a suitable candidate for research in the POCT field. MDPI 2018-10-27 /pmc/articles/PMC6266334/ /pubmed/30715051 http://dx.doi.org/10.3390/mi9110552 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mehrdel, Pouya Karimi, Shadi Farré-Lladós, Josep Casals-Terré, Jasmina Novel Variable Radius Spiral–Shaped Micromixer: From Numerical Analysis to Experimental Validation |
title | Novel Variable Radius Spiral–Shaped Micromixer: From Numerical Analysis to Experimental Validation |
title_full | Novel Variable Radius Spiral–Shaped Micromixer: From Numerical Analysis to Experimental Validation |
title_fullStr | Novel Variable Radius Spiral–Shaped Micromixer: From Numerical Analysis to Experimental Validation |
title_full_unstemmed | Novel Variable Radius Spiral–Shaped Micromixer: From Numerical Analysis to Experimental Validation |
title_short | Novel Variable Radius Spiral–Shaped Micromixer: From Numerical Analysis to Experimental Validation |
title_sort | novel variable radius spiral–shaped micromixer: from numerical analysis to experimental validation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266334/ https://www.ncbi.nlm.nih.gov/pubmed/30715051 http://dx.doi.org/10.3390/mi9110552 |
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