The Role of the Anti-Aging Protein Klotho in IGF-1 Signaling and Reticular Calcium Leak: Impact on the Chemosensitivity of Dedifferentiated Liposarcomas

By inhibiting Insulin-Like Growth Factor-1-Receptor (IGF-1R) signaling, Klotho (KL) acts like an aging- and tumor-suppressor. We investigated whether KL impacts the aggressiveness of liposarcomas, in which IGF-1R signaling is frequently upregulated. Indeed, we observed that a higher KL expression in...

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Detalles Bibliográficos
Autores principales: Delcroix, Vanessa, Mauduit, Olivier, Tessier, Nolwenn, Montillaud, Anaïs, Lesluyes, Tom, Ducret, Thomas, Chibon, Frédéric, Van Coppenolle, Fabien, Ducreux, Sylvie, Vacher, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266342/
https://www.ncbi.nlm.nih.gov/pubmed/30441794
http://dx.doi.org/10.3390/cancers10110439

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