Cargando…

High preoperative plasma vasohibin‐1 concentration predicts better prognosis in patients with non–small cell lung carcinoma

BACKGROUND AND AIM: Vasohibin‐1 (VASH1) is an angiogenesis inhibitor synthesized and secreted by endothelial cells, whose expression is induced by angiogenic stimuli such as vascular endothelial growth factor. We have previously demonstrated that VASH1 is immunohistochemically evident in endothelial...

Descripción completa

Detalles Bibliográficos
Autores principales: Watanabe, Tatsuaki, Hosaka, Tomoko, Ohmori‐Matsuda, Kaori, Suzuki, Yasuhiro, Suzuki, Hirotoshi, Yabuki, Hiroshi, Matsuda, Yasushi, Noda, Masafumi, Sakurada, Akira, Okada, Yoshinori, Sato, Yasufumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266348/
https://www.ncbi.nlm.nih.gov/pubmed/30623077
http://dx.doi.org/10.1002/hsr2.40
_version_ 1783375818973511680
author Watanabe, Tatsuaki
Hosaka, Tomoko
Ohmori‐Matsuda, Kaori
Suzuki, Yasuhiro
Suzuki, Hirotoshi
Yabuki, Hiroshi
Matsuda, Yasushi
Noda, Masafumi
Sakurada, Akira
Okada, Yoshinori
Sato, Yasufumi
author_facet Watanabe, Tatsuaki
Hosaka, Tomoko
Ohmori‐Matsuda, Kaori
Suzuki, Yasuhiro
Suzuki, Hirotoshi
Yabuki, Hiroshi
Matsuda, Yasushi
Noda, Masafumi
Sakurada, Akira
Okada, Yoshinori
Sato, Yasufumi
author_sort Watanabe, Tatsuaki
collection PubMed
description BACKGROUND AND AIM: Vasohibin‐1 (VASH1) is an angiogenesis inhibitor synthesized and secreted by endothelial cells, whose expression is induced by angiogenic stimuli such as vascular endothelial growth factor. We have previously demonstrated that VASH1 is immunohistochemically evident in endothelial cells in the tumor microenvironment of patients with non–small cell lung cancer (NSCLC) and is positively correlated with that of vascular endothelial growth factor in cancer cells. Here, we determined the preoperative plasma concentration of VASH1 in patients with NSCLC and evaluated the association between the preoperative VASH1 levels and certain outcomes. METHODS: We analyzed presurgical plasma VASH1 concentrations in a total of 79 lung cancer patients (51 males and 28 females; 34‐83 y of age; 46 adenocarcinomas, 27 squamous cell carcinomas, and 6 other types) who underwent lung resection. The impact of preoperative VASH1 level was analyzed using clinical characteristics and prognosis. RESULTS: Plasma VASH1 concentration ranged from 34.1 to 1190.4 fmol/mL. We divided the patients into 3 groups according to plasma VASH1 level for this assessment: low VASH1 group (n = 26), medium VASH1 group (n = 27), and high VASH1 group (n = 26). The death and recurrence rates of the high, medium, and low VASH1 groups were 5.5, 16.2, and 12.7 per 100 person‐years, respectively. Multivariate adjusted hazard ratio of death and recurrence of the high VASH1 group was lower than that of the low VASH1 group (hazard ratio 0.42; 95% CI 0.17‐0.99). CONCLUSION: The present analysis suggests that high preoperative plasma VASH1 concentration is associated with better prognosis in patients with NSCLC. We propose preoperative VASH1 level as a biomarker for the prognosis of patients with non–small cell lung carcinoma.
format Online
Article
Text
id pubmed-6266348
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-62663482019-01-08 High preoperative plasma vasohibin‐1 concentration predicts better prognosis in patients with non–small cell lung carcinoma Watanabe, Tatsuaki Hosaka, Tomoko Ohmori‐Matsuda, Kaori Suzuki, Yasuhiro Suzuki, Hirotoshi Yabuki, Hiroshi Matsuda, Yasushi Noda, Masafumi Sakurada, Akira Okada, Yoshinori Sato, Yasufumi Health Sci Rep Research Articles BACKGROUND AND AIM: Vasohibin‐1 (VASH1) is an angiogenesis inhibitor synthesized and secreted by endothelial cells, whose expression is induced by angiogenic stimuli such as vascular endothelial growth factor. We have previously demonstrated that VASH1 is immunohistochemically evident in endothelial cells in the tumor microenvironment of patients with non–small cell lung cancer (NSCLC) and is positively correlated with that of vascular endothelial growth factor in cancer cells. Here, we determined the preoperative plasma concentration of VASH1 in patients with NSCLC and evaluated the association between the preoperative VASH1 levels and certain outcomes. METHODS: We analyzed presurgical plasma VASH1 concentrations in a total of 79 lung cancer patients (51 males and 28 females; 34‐83 y of age; 46 adenocarcinomas, 27 squamous cell carcinomas, and 6 other types) who underwent lung resection. The impact of preoperative VASH1 level was analyzed using clinical characteristics and prognosis. RESULTS: Plasma VASH1 concentration ranged from 34.1 to 1190.4 fmol/mL. We divided the patients into 3 groups according to plasma VASH1 level for this assessment: low VASH1 group (n = 26), medium VASH1 group (n = 27), and high VASH1 group (n = 26). The death and recurrence rates of the high, medium, and low VASH1 groups were 5.5, 16.2, and 12.7 per 100 person‐years, respectively. Multivariate adjusted hazard ratio of death and recurrence of the high VASH1 group was lower than that of the low VASH1 group (hazard ratio 0.42; 95% CI 0.17‐0.99). CONCLUSION: The present analysis suggests that high preoperative plasma VASH1 concentration is associated with better prognosis in patients with NSCLC. We propose preoperative VASH1 level as a biomarker for the prognosis of patients with non–small cell lung carcinoma. John Wiley and Sons Inc. 2018-05-17 /pmc/articles/PMC6266348/ /pubmed/30623077 http://dx.doi.org/10.1002/hsr2.40 Text en © 2018 The Authors. Health Science Reports published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Watanabe, Tatsuaki
Hosaka, Tomoko
Ohmori‐Matsuda, Kaori
Suzuki, Yasuhiro
Suzuki, Hirotoshi
Yabuki, Hiroshi
Matsuda, Yasushi
Noda, Masafumi
Sakurada, Akira
Okada, Yoshinori
Sato, Yasufumi
High preoperative plasma vasohibin‐1 concentration predicts better prognosis in patients with non–small cell lung carcinoma
title High preoperative plasma vasohibin‐1 concentration predicts better prognosis in patients with non–small cell lung carcinoma
title_full High preoperative plasma vasohibin‐1 concentration predicts better prognosis in patients with non–small cell lung carcinoma
title_fullStr High preoperative plasma vasohibin‐1 concentration predicts better prognosis in patients with non–small cell lung carcinoma
title_full_unstemmed High preoperative plasma vasohibin‐1 concentration predicts better prognosis in patients with non–small cell lung carcinoma
title_short High preoperative plasma vasohibin‐1 concentration predicts better prognosis in patients with non–small cell lung carcinoma
title_sort high preoperative plasma vasohibin‐1 concentration predicts better prognosis in patients with non–small cell lung carcinoma
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266348/
https://www.ncbi.nlm.nih.gov/pubmed/30623077
http://dx.doi.org/10.1002/hsr2.40
work_keys_str_mv AT watanabetatsuaki highpreoperativeplasmavasohibin1concentrationpredictsbetterprognosisinpatientswithnonsmallcelllungcarcinoma
AT hosakatomoko highpreoperativeplasmavasohibin1concentrationpredictsbetterprognosisinpatientswithnonsmallcelllungcarcinoma
AT ohmorimatsudakaori highpreoperativeplasmavasohibin1concentrationpredictsbetterprognosisinpatientswithnonsmallcelllungcarcinoma
AT suzukiyasuhiro highpreoperativeplasmavasohibin1concentrationpredictsbetterprognosisinpatientswithnonsmallcelllungcarcinoma
AT suzukihirotoshi highpreoperativeplasmavasohibin1concentrationpredictsbetterprognosisinpatientswithnonsmallcelllungcarcinoma
AT yabukihiroshi highpreoperativeplasmavasohibin1concentrationpredictsbetterprognosisinpatientswithnonsmallcelllungcarcinoma
AT matsudayasushi highpreoperativeplasmavasohibin1concentrationpredictsbetterprognosisinpatientswithnonsmallcelllungcarcinoma
AT nodamasafumi highpreoperativeplasmavasohibin1concentrationpredictsbetterprognosisinpatientswithnonsmallcelllungcarcinoma
AT sakuradaakira highpreoperativeplasmavasohibin1concentrationpredictsbetterprognosisinpatientswithnonsmallcelllungcarcinoma
AT okadayoshinori highpreoperativeplasmavasohibin1concentrationpredictsbetterprognosisinpatientswithnonsmallcelllungcarcinoma
AT satoyasufumi highpreoperativeplasmavasohibin1concentrationpredictsbetterprognosisinpatientswithnonsmallcelllungcarcinoma