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Comparison of the nasopharynx microbiome between influenza and non‐influenza cases of severe acute respiratory infections: A pilot study
AIMS: Influenza A virus (IAV) can cause severe acute respiratory infection (SARI), and disease outcome may be associated with changes in the microbiome of the nasopharynx. This is a pilot study to characterize the microbiome of the nasopharynx in patients hospitalized with SARI, infected and not inf...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266421/ https://www.ncbi.nlm.nih.gov/pubmed/30623080 http://dx.doi.org/10.1002/hsr2.47 |
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author | Borges, Luiz Gustavo dos Anjos Giongo, Adriana Pereira, Leandro de Mattos Trindade, Fernanda J. Gregianini, Tatiana Schäffer Campos, Fabrício Souza Ghedin, Elodie da Veiga, Ana Beatriz Gorini |
author_facet | Borges, Luiz Gustavo dos Anjos Giongo, Adriana Pereira, Leandro de Mattos Trindade, Fernanda J. Gregianini, Tatiana Schäffer Campos, Fabrício Souza Ghedin, Elodie da Veiga, Ana Beatriz Gorini |
author_sort | Borges, Luiz Gustavo dos Anjos |
collection | PubMed |
description | AIMS: Influenza A virus (IAV) can cause severe acute respiratory infection (SARI), and disease outcome may be associated with changes in the microbiome of the nasopharynx. This is a pilot study to characterize the microbiome of the nasopharynx in patients hospitalized with SARI, infected and not infected by IAV. METHODS AND RESULTS: Using target sequencing of the 16S rRNA gene, we assessed the bacterial community of nasopharyngeal aspirate samples and compared the microbiome of patients infected with IAV with the microbiome of patients who were negative for IAV. We observed differences in the relative abundance of Proteobacteria and Firmicutes between SARI patients, with Streptococcus being enriched and Pseudomonas underrepresented in IAV patients compared with patients who were not infected with IAV. CONCLUSION: Pseudomonas taxon seems to be in high frequency on the nasopharynx of SARI patients with non‐IAV infection and might present a negative association with Streptococcus taxon. Microbial profile appears to be different between SARI patients infected or not infected with IAV. |
format | Online Article Text |
id | pubmed-6266421 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62664212019-01-08 Comparison of the nasopharynx microbiome between influenza and non‐influenza cases of severe acute respiratory infections: A pilot study Borges, Luiz Gustavo dos Anjos Giongo, Adriana Pereira, Leandro de Mattos Trindade, Fernanda J. Gregianini, Tatiana Schäffer Campos, Fabrício Souza Ghedin, Elodie da Veiga, Ana Beatriz Gorini Health Sci Rep Research Articles AIMS: Influenza A virus (IAV) can cause severe acute respiratory infection (SARI), and disease outcome may be associated with changes in the microbiome of the nasopharynx. This is a pilot study to characterize the microbiome of the nasopharynx in patients hospitalized with SARI, infected and not infected by IAV. METHODS AND RESULTS: Using target sequencing of the 16S rRNA gene, we assessed the bacterial community of nasopharyngeal aspirate samples and compared the microbiome of patients infected with IAV with the microbiome of patients who were negative for IAV. We observed differences in the relative abundance of Proteobacteria and Firmicutes between SARI patients, with Streptococcus being enriched and Pseudomonas underrepresented in IAV patients compared with patients who were not infected with IAV. CONCLUSION: Pseudomonas taxon seems to be in high frequency on the nasopharynx of SARI patients with non‐IAV infection and might present a negative association with Streptococcus taxon. Microbial profile appears to be different between SARI patients infected or not infected with IAV. John Wiley and Sons Inc. 2018-05-09 /pmc/articles/PMC6266421/ /pubmed/30623080 http://dx.doi.org/10.1002/hsr2.47 Text en © 2018 The Authors. Health Science Reports published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Borges, Luiz Gustavo dos Anjos Giongo, Adriana Pereira, Leandro de Mattos Trindade, Fernanda J. Gregianini, Tatiana Schäffer Campos, Fabrício Souza Ghedin, Elodie da Veiga, Ana Beatriz Gorini Comparison of the nasopharynx microbiome between influenza and non‐influenza cases of severe acute respiratory infections: A pilot study |
title | Comparison of the nasopharynx microbiome between influenza and non‐influenza cases of severe acute respiratory infections: A pilot study |
title_full | Comparison of the nasopharynx microbiome between influenza and non‐influenza cases of severe acute respiratory infections: A pilot study |
title_fullStr | Comparison of the nasopharynx microbiome between influenza and non‐influenza cases of severe acute respiratory infections: A pilot study |
title_full_unstemmed | Comparison of the nasopharynx microbiome between influenza and non‐influenza cases of severe acute respiratory infections: A pilot study |
title_short | Comparison of the nasopharynx microbiome between influenza and non‐influenza cases of severe acute respiratory infections: A pilot study |
title_sort | comparison of the nasopharynx microbiome between influenza and non‐influenza cases of severe acute respiratory infections: a pilot study |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266421/ https://www.ncbi.nlm.nih.gov/pubmed/30623080 http://dx.doi.org/10.1002/hsr2.47 |
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