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Comparison of the nasopharynx microbiome between influenza and non‐influenza cases of severe acute respiratory infections: A pilot study

AIMS: Influenza A virus (IAV) can cause severe acute respiratory infection (SARI), and disease outcome may be associated with changes in the microbiome of the nasopharynx. This is a pilot study to characterize the microbiome of the nasopharynx in patients hospitalized with SARI, infected and not inf...

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Autores principales: Borges, Luiz Gustavo dos Anjos, Giongo, Adriana, Pereira, Leandro de Mattos, Trindade, Fernanda J., Gregianini, Tatiana Schäffer, Campos, Fabrício Souza, Ghedin, Elodie, da Veiga, Ana Beatriz Gorini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266421/
https://www.ncbi.nlm.nih.gov/pubmed/30623080
http://dx.doi.org/10.1002/hsr2.47
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author Borges, Luiz Gustavo dos Anjos
Giongo, Adriana
Pereira, Leandro de Mattos
Trindade, Fernanda J.
Gregianini, Tatiana Schäffer
Campos, Fabrício Souza
Ghedin, Elodie
da Veiga, Ana Beatriz Gorini
author_facet Borges, Luiz Gustavo dos Anjos
Giongo, Adriana
Pereira, Leandro de Mattos
Trindade, Fernanda J.
Gregianini, Tatiana Schäffer
Campos, Fabrício Souza
Ghedin, Elodie
da Veiga, Ana Beatriz Gorini
author_sort Borges, Luiz Gustavo dos Anjos
collection PubMed
description AIMS: Influenza A virus (IAV) can cause severe acute respiratory infection (SARI), and disease outcome may be associated with changes in the microbiome of the nasopharynx. This is a pilot study to characterize the microbiome of the nasopharynx in patients hospitalized with SARI, infected and not infected by IAV. METHODS AND RESULTS: Using target sequencing of the 16S rRNA gene, we assessed the bacterial community of nasopharyngeal aspirate samples and compared the microbiome of patients infected with IAV with the microbiome of patients who were negative for IAV. We observed differences in the relative abundance of Proteobacteria and Firmicutes between SARI patients, with Streptococcus being enriched and Pseudomonas underrepresented in IAV patients compared with patients who were not infected with IAV. CONCLUSION: Pseudomonas taxon seems to be in high frequency on the nasopharynx of SARI patients with non‐IAV infection and might present a negative association with Streptococcus taxon. Microbial profile appears to be different between SARI patients infected or not infected with IAV.
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spelling pubmed-62664212019-01-08 Comparison of the nasopharynx microbiome between influenza and non‐influenza cases of severe acute respiratory infections: A pilot study Borges, Luiz Gustavo dos Anjos Giongo, Adriana Pereira, Leandro de Mattos Trindade, Fernanda J. Gregianini, Tatiana Schäffer Campos, Fabrício Souza Ghedin, Elodie da Veiga, Ana Beatriz Gorini Health Sci Rep Research Articles AIMS: Influenza A virus (IAV) can cause severe acute respiratory infection (SARI), and disease outcome may be associated with changes in the microbiome of the nasopharynx. This is a pilot study to characterize the microbiome of the nasopharynx in patients hospitalized with SARI, infected and not infected by IAV. METHODS AND RESULTS: Using target sequencing of the 16S rRNA gene, we assessed the bacterial community of nasopharyngeal aspirate samples and compared the microbiome of patients infected with IAV with the microbiome of patients who were negative for IAV. We observed differences in the relative abundance of Proteobacteria and Firmicutes between SARI patients, with Streptococcus being enriched and Pseudomonas underrepresented in IAV patients compared with patients who were not infected with IAV. CONCLUSION: Pseudomonas taxon seems to be in high frequency on the nasopharynx of SARI patients with non‐IAV infection and might present a negative association with Streptococcus taxon. Microbial profile appears to be different between SARI patients infected or not infected with IAV. John Wiley and Sons Inc. 2018-05-09 /pmc/articles/PMC6266421/ /pubmed/30623080 http://dx.doi.org/10.1002/hsr2.47 Text en © 2018 The Authors. Health Science Reports published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Borges, Luiz Gustavo dos Anjos
Giongo, Adriana
Pereira, Leandro de Mattos
Trindade, Fernanda J.
Gregianini, Tatiana Schäffer
Campos, Fabrício Souza
Ghedin, Elodie
da Veiga, Ana Beatriz Gorini
Comparison of the nasopharynx microbiome between influenza and non‐influenza cases of severe acute respiratory infections: A pilot study
title Comparison of the nasopharynx microbiome between influenza and non‐influenza cases of severe acute respiratory infections: A pilot study
title_full Comparison of the nasopharynx microbiome between influenza and non‐influenza cases of severe acute respiratory infections: A pilot study
title_fullStr Comparison of the nasopharynx microbiome between influenza and non‐influenza cases of severe acute respiratory infections: A pilot study
title_full_unstemmed Comparison of the nasopharynx microbiome between influenza and non‐influenza cases of severe acute respiratory infections: A pilot study
title_short Comparison of the nasopharynx microbiome between influenza and non‐influenza cases of severe acute respiratory infections: A pilot study
title_sort comparison of the nasopharynx microbiome between influenza and non‐influenza cases of severe acute respiratory infections: a pilot study
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266421/
https://www.ncbi.nlm.nih.gov/pubmed/30623080
http://dx.doi.org/10.1002/hsr2.47
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