Synthesis and Evaluation of Spumigin Analogues Library with Thrombin Inhibitory Activity

Spumigins are marine natural products derived from cyanobacteria Nodularia spumigena, which mimics the structure of the d-Phe-Pro-Arg sequence and is crucial for binding to the active site of serine proteases thrombin and factor Xa. Biological evaluation of spumigins showed that spumigins with a (2S...

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Detalles Bibliográficos
Autores principales: Žula, Aleš, Będziak, Izabela, Kikelj, Danijel, Ilaš, Janez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266488/
https://www.ncbi.nlm.nih.gov/pubmed/30373260
http://dx.doi.org/10.3390/md16110413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266488/
https://www.ncbi.nlm.nih.gov/pubmed/30373260
http://dx.doi.org/10.3390/md16110413

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