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Synthesis and Evaluation of Spumigin Analogues Library with Thrombin Inhibitory Activity
Spumigins are marine natural products derived from cyanobacteria Nodularia spumigena, which mimics the structure of the d-Phe-Pro-Arg sequence and is crucial for binding to the active site of serine proteases thrombin and factor Xa. Biological evaluation of spumigins showed that spumigins with a (2S...
Autores principales: | Žula, Aleš, Będziak, Izabela, Kikelj, Danijel, Ilaš, Janez |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266488/ https://www.ncbi.nlm.nih.gov/pubmed/30373260 http://dx.doi.org/10.3390/md16110413 |
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