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Mechanisms of Lysophosphatidic Acid-Mediated Lymphangiogenesis in Prostate Cancer

Prostate cancer (PCa) is the most common noncutaneous cancer in men worldwide. One of its major treatments is androgen deprivation therapy, but PCa frequently relapses as aggressive castration resistant local tumors and distal metastases. Hence, the development of novel agents or treatment modalitie...

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Autores principales: Wu, Pei-Yi, Lin, Yueh-Chien, Huang, Yuan-Li, Chen, Wei-Min, Chen, Chien-Chin, Lee, Hsinyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266502/
https://www.ncbi.nlm.nih.gov/pubmed/30384405
http://dx.doi.org/10.3390/cancers10110413
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author Wu, Pei-Yi
Lin, Yueh-Chien
Huang, Yuan-Li
Chen, Wei-Min
Chen, Chien-Chin
Lee, Hsinyu
author_facet Wu, Pei-Yi
Lin, Yueh-Chien
Huang, Yuan-Li
Chen, Wei-Min
Chen, Chien-Chin
Lee, Hsinyu
author_sort Wu, Pei-Yi
collection PubMed
description Prostate cancer (PCa) is the most common noncutaneous cancer in men worldwide. One of its major treatments is androgen deprivation therapy, but PCa frequently relapses as aggressive castration resistant local tumors and distal metastases. Hence, the development of novel agents or treatment modalities for advanced PCa is crucial. Many tumors, including PCa, first metastasize to regional lymph nodes via lymphatic vessels. Recent findings demonstrate that the bioactive lipid lysophosphatidic acid (LPA) promotes PCa progression by regulating vascular endothelial growth factor-C (VEGF-C), a critical mediator of tumor lymphangiogenesis and lymphatic metastasis. Many of the underlying molecular mechanisms of the LPA–VEGF-C axis have been described, revealing potential biomarkers and therapeutic targets that may aid in the diagnosis and treatment of advanced PCa. Herein, we review the literature that illustrates a functional role for LPA signaling in PCa progression. These discoveries may be especially applicable to anti-lymphangiogenic strategies for the prevention and therapy of metastatic PCa.
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spelling pubmed-62665022018-12-03 Mechanisms of Lysophosphatidic Acid-Mediated Lymphangiogenesis in Prostate Cancer Wu, Pei-Yi Lin, Yueh-Chien Huang, Yuan-Li Chen, Wei-Min Chen, Chien-Chin Lee, Hsinyu Cancers (Basel) Review Prostate cancer (PCa) is the most common noncutaneous cancer in men worldwide. One of its major treatments is androgen deprivation therapy, but PCa frequently relapses as aggressive castration resistant local tumors and distal metastases. Hence, the development of novel agents or treatment modalities for advanced PCa is crucial. Many tumors, including PCa, first metastasize to regional lymph nodes via lymphatic vessels. Recent findings demonstrate that the bioactive lipid lysophosphatidic acid (LPA) promotes PCa progression by regulating vascular endothelial growth factor-C (VEGF-C), a critical mediator of tumor lymphangiogenesis and lymphatic metastasis. Many of the underlying molecular mechanisms of the LPA–VEGF-C axis have been described, revealing potential biomarkers and therapeutic targets that may aid in the diagnosis and treatment of advanced PCa. Herein, we review the literature that illustrates a functional role for LPA signaling in PCa progression. These discoveries may be especially applicable to anti-lymphangiogenic strategies for the prevention and therapy of metastatic PCa. MDPI 2018-10-31 /pmc/articles/PMC6266502/ /pubmed/30384405 http://dx.doi.org/10.3390/cancers10110413 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wu, Pei-Yi
Lin, Yueh-Chien
Huang, Yuan-Li
Chen, Wei-Min
Chen, Chien-Chin
Lee, Hsinyu
Mechanisms of Lysophosphatidic Acid-Mediated Lymphangiogenesis in Prostate Cancer
title Mechanisms of Lysophosphatidic Acid-Mediated Lymphangiogenesis in Prostate Cancer
title_full Mechanisms of Lysophosphatidic Acid-Mediated Lymphangiogenesis in Prostate Cancer
title_fullStr Mechanisms of Lysophosphatidic Acid-Mediated Lymphangiogenesis in Prostate Cancer
title_full_unstemmed Mechanisms of Lysophosphatidic Acid-Mediated Lymphangiogenesis in Prostate Cancer
title_short Mechanisms of Lysophosphatidic Acid-Mediated Lymphangiogenesis in Prostate Cancer
title_sort mechanisms of lysophosphatidic acid-mediated lymphangiogenesis in prostate cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266502/
https://www.ncbi.nlm.nih.gov/pubmed/30384405
http://dx.doi.org/10.3390/cancers10110413
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