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Cytomegalovirus Pneumonia with Progressive Lung Volume Loss

Case series Patients: Male, 65 • Male, 63 • Female, 35 Final Diagnosis: CMV pneumonia Symptoms: Respiratory failure Medication: — Clinical Procedure: Excepting diagnosis Specialty: Pulmonology OBJECTIVE: Unusual clinical course BACKGROUND: Cytomegalovirus (CMV) pneumonia is common in immunocompromis...

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Autores principales: Shionoya, Yu, Kasai, Hajime, Terada, Jiro, Abe, Mitsuhiro, Takeda, Yusuke, Sakaida, Emiko, Tanabe, Nobuhiro, Tatsumi, Koichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266627/
https://www.ncbi.nlm.nih.gov/pubmed/30467305
http://dx.doi.org/10.12659/AJCR.911708
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author Shionoya, Yu
Kasai, Hajime
Terada, Jiro
Abe, Mitsuhiro
Takeda, Yusuke
Sakaida, Emiko
Tanabe, Nobuhiro
Tatsumi, Koichiro
author_facet Shionoya, Yu
Kasai, Hajime
Terada, Jiro
Abe, Mitsuhiro
Takeda, Yusuke
Sakaida, Emiko
Tanabe, Nobuhiro
Tatsumi, Koichiro
author_sort Shionoya, Yu
collection PubMed
description Case series Patients: Male, 65 • Male, 63 • Female, 35 Final Diagnosis: CMV pneumonia Symptoms: Respiratory failure Medication: — Clinical Procedure: Excepting diagnosis Specialty: Pulmonology OBJECTIVE: Unusual clinical course BACKGROUND: Cytomegalovirus (CMV) pneumonia is common in immunocompromised patients with hematological malignancies. Although the spectrum of illness caused by CMV is well-documented in immunocompromised patients, the clinical course and evolution of lung changes after initiation of antiviral therapy remain unclear. CASE REPORT: We present the cases of 3 patients with leukemia who developed CMV pneumonia following cord blood transplantation and who presented with distinctive features on chest computed tomography (CT). In all patients, chest CT showed central peribronchial changes with severe lung volume loss. Furthermore, the patients were refractory to high-dose steroids, and the lung volume loss rapidly progressed, leading to death from respiratory failure. CONCLUSIONS: We observed central peribronchial changes with severe lung volume loss after the acute phase in 3 cases of CMV pneumonia. While our diagnosis was made on the basis of exclusion, it is important to bear in mind that lung involvement in CMV pneumonia may be refractory to various treatment modalities and can lead to a fatal clinical course.
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spelling pubmed-62666272018-12-21 Cytomegalovirus Pneumonia with Progressive Lung Volume Loss Shionoya, Yu Kasai, Hajime Terada, Jiro Abe, Mitsuhiro Takeda, Yusuke Sakaida, Emiko Tanabe, Nobuhiro Tatsumi, Koichiro Am J Case Rep Articles Case series Patients: Male, 65 • Male, 63 • Female, 35 Final Diagnosis: CMV pneumonia Symptoms: Respiratory failure Medication: — Clinical Procedure: Excepting diagnosis Specialty: Pulmonology OBJECTIVE: Unusual clinical course BACKGROUND: Cytomegalovirus (CMV) pneumonia is common in immunocompromised patients with hematological malignancies. Although the spectrum of illness caused by CMV is well-documented in immunocompromised patients, the clinical course and evolution of lung changes after initiation of antiviral therapy remain unclear. CASE REPORT: We present the cases of 3 patients with leukemia who developed CMV pneumonia following cord blood transplantation and who presented with distinctive features on chest computed tomography (CT). In all patients, chest CT showed central peribronchial changes with severe lung volume loss. Furthermore, the patients were refractory to high-dose steroids, and the lung volume loss rapidly progressed, leading to death from respiratory failure. CONCLUSIONS: We observed central peribronchial changes with severe lung volume loss after the acute phase in 3 cases of CMV pneumonia. While our diagnosis was made on the basis of exclusion, it is important to bear in mind that lung involvement in CMV pneumonia may be refractory to various treatment modalities and can lead to a fatal clinical course. International Scientific Literature, Inc. 2018-11-23 /pmc/articles/PMC6266627/ /pubmed/30467305 http://dx.doi.org/10.12659/AJCR.911708 Text en © Am J Case Rep, 2018 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Articles
Shionoya, Yu
Kasai, Hajime
Terada, Jiro
Abe, Mitsuhiro
Takeda, Yusuke
Sakaida, Emiko
Tanabe, Nobuhiro
Tatsumi, Koichiro
Cytomegalovirus Pneumonia with Progressive Lung Volume Loss
title Cytomegalovirus Pneumonia with Progressive Lung Volume Loss
title_full Cytomegalovirus Pneumonia with Progressive Lung Volume Loss
title_fullStr Cytomegalovirus Pneumonia with Progressive Lung Volume Loss
title_full_unstemmed Cytomegalovirus Pneumonia with Progressive Lung Volume Loss
title_short Cytomegalovirus Pneumonia with Progressive Lung Volume Loss
title_sort cytomegalovirus pneumonia with progressive lung volume loss
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266627/
https://www.ncbi.nlm.nih.gov/pubmed/30467305
http://dx.doi.org/10.12659/AJCR.911708
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