Cargando…
Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer
Breast cancer (BC) is the most common type of cancer in women worldwide; it is a multifactorial genetic disease. Acetylation and deacetylation are major post-translational protein modifications that regulate gene expression and the activity of a myriad of oncoproteins. Aberrant deacetylase activity...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266715/ https://www.ncbi.nlm.nih.gov/pubmed/30380732 http://dx.doi.org/10.3390/cancers10110409 |
_version_ | 1783375901854007296 |
---|---|
author | Rifaï, Khaldoun Idrissou, Mouhamed Penault-Llorca, Frédérique Bignon, Yves-Jean Bernard-Gallon, Dominique |
author_facet | Rifaï, Khaldoun Idrissou, Mouhamed Penault-Llorca, Frédérique Bignon, Yves-Jean Bernard-Gallon, Dominique |
author_sort | Rifaï, Khaldoun |
collection | PubMed |
description | Breast cancer (BC) is the most common type of cancer in women worldwide; it is a multifactorial genetic disease. Acetylation and deacetylation are major post-translational protein modifications that regulate gene expression and the activity of a myriad of oncoproteins. Aberrant deacetylase activity can promote or suppress tumorigenesis and cancer metastasis in different types of human cancers, including breast cancer. Sirtuin-1 (SIRT1) is a class-III histone deacetylase (HDAC) that deacetylates both histone and non-histone targets. The often-described ‘regulator of regulators’ is deeply implicated in apoptosis, gene regulation, genome maintenance, DNA repair, aging, and cancer development. However, despite the accumulated studies over the past decade, the role of SIRT1 in human breast cancer remains a subject of debate and controversy. The ambiguity surrounding the implications of SIRT1 in breast tumorigenesis stems from the discrepancy between studies, which have shown both tumor-suppressive and promoting functions of SIRT1. Furthermore, studies have shown that SIRT1 deficiency promotes or suppresses tumors in breast cancer, making it an attractive therapeutic target in cancer treatment. This review provides a comprehensive examination of the various implications of SIRT1 in breast cancer development and metastasis. We will also discuss the mechanisms underlying the conflicting roles of SIRT1, as well as its selective modulators, in breast carcinogenesis. |
format | Online Article Text |
id | pubmed-6266715 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62667152018-12-03 Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer Rifaï, Khaldoun Idrissou, Mouhamed Penault-Llorca, Frédérique Bignon, Yves-Jean Bernard-Gallon, Dominique Cancers (Basel) Review Breast cancer (BC) is the most common type of cancer in women worldwide; it is a multifactorial genetic disease. Acetylation and deacetylation are major post-translational protein modifications that regulate gene expression and the activity of a myriad of oncoproteins. Aberrant deacetylase activity can promote or suppress tumorigenesis and cancer metastasis in different types of human cancers, including breast cancer. Sirtuin-1 (SIRT1) is a class-III histone deacetylase (HDAC) that deacetylates both histone and non-histone targets. The often-described ‘regulator of regulators’ is deeply implicated in apoptosis, gene regulation, genome maintenance, DNA repair, aging, and cancer development. However, despite the accumulated studies over the past decade, the role of SIRT1 in human breast cancer remains a subject of debate and controversy. The ambiguity surrounding the implications of SIRT1 in breast tumorigenesis stems from the discrepancy between studies, which have shown both tumor-suppressive and promoting functions of SIRT1. Furthermore, studies have shown that SIRT1 deficiency promotes or suppresses tumors in breast cancer, making it an attractive therapeutic target in cancer treatment. This review provides a comprehensive examination of the various implications of SIRT1 in breast cancer development and metastasis. We will also discuss the mechanisms underlying the conflicting roles of SIRT1, as well as its selective modulators, in breast carcinogenesis. MDPI 2018-10-30 /pmc/articles/PMC6266715/ /pubmed/30380732 http://dx.doi.org/10.3390/cancers10110409 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rifaï, Khaldoun Idrissou, Mouhamed Penault-Llorca, Frédérique Bignon, Yves-Jean Bernard-Gallon, Dominique Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer |
title | Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer |
title_full | Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer |
title_fullStr | Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer |
title_full_unstemmed | Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer |
title_short | Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer |
title_sort | breaking down the contradictory roles of histone deacetylase sirt1 in human breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266715/ https://www.ncbi.nlm.nih.gov/pubmed/30380732 http://dx.doi.org/10.3390/cancers10110409 |
work_keys_str_mv | AT rifaikhaldoun breakingdownthecontradictoryrolesofhistonedeacetylasesirt1inhumanbreastcancer AT idrissoumouhamed breakingdownthecontradictoryrolesofhistonedeacetylasesirt1inhumanbreastcancer AT penaultllorcafrederique breakingdownthecontradictoryrolesofhistonedeacetylasesirt1inhumanbreastcancer AT bignonyvesjean breakingdownthecontradictoryrolesofhistonedeacetylasesirt1inhumanbreastcancer AT bernardgallondominique breakingdownthecontradictoryrolesofhistonedeacetylasesirt1inhumanbreastcancer |