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Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer

Breast cancer (BC) is the most common type of cancer in women worldwide; it is a multifactorial genetic disease. Acetylation and deacetylation are major post-translational protein modifications that regulate gene expression and the activity of a myriad of oncoproteins. Aberrant deacetylase activity...

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Autores principales: Rifaï, Khaldoun, Idrissou, Mouhamed, Penault-Llorca, Frédérique, Bignon, Yves-Jean, Bernard-Gallon, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266715/
https://www.ncbi.nlm.nih.gov/pubmed/30380732
http://dx.doi.org/10.3390/cancers10110409
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author Rifaï, Khaldoun
Idrissou, Mouhamed
Penault-Llorca, Frédérique
Bignon, Yves-Jean
Bernard-Gallon, Dominique
author_facet Rifaï, Khaldoun
Idrissou, Mouhamed
Penault-Llorca, Frédérique
Bignon, Yves-Jean
Bernard-Gallon, Dominique
author_sort Rifaï, Khaldoun
collection PubMed
description Breast cancer (BC) is the most common type of cancer in women worldwide; it is a multifactorial genetic disease. Acetylation and deacetylation are major post-translational protein modifications that regulate gene expression and the activity of a myriad of oncoproteins. Aberrant deacetylase activity can promote or suppress tumorigenesis and cancer metastasis in different types of human cancers, including breast cancer. Sirtuin-1 (SIRT1) is a class-III histone deacetylase (HDAC) that deacetylates both histone and non-histone targets. The often-described ‘regulator of regulators’ is deeply implicated in apoptosis, gene regulation, genome maintenance, DNA repair, aging, and cancer development. However, despite the accumulated studies over the past decade, the role of SIRT1 in human breast cancer remains a subject of debate and controversy. The ambiguity surrounding the implications of SIRT1 in breast tumorigenesis stems from the discrepancy between studies, which have shown both tumor-suppressive and promoting functions of SIRT1. Furthermore, studies have shown that SIRT1 deficiency promotes or suppresses tumors in breast cancer, making it an attractive therapeutic target in cancer treatment. This review provides a comprehensive examination of the various implications of SIRT1 in breast cancer development and metastasis. We will also discuss the mechanisms underlying the conflicting roles of SIRT1, as well as its selective modulators, in breast carcinogenesis.
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spelling pubmed-62667152018-12-03 Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer Rifaï, Khaldoun Idrissou, Mouhamed Penault-Llorca, Frédérique Bignon, Yves-Jean Bernard-Gallon, Dominique Cancers (Basel) Review Breast cancer (BC) is the most common type of cancer in women worldwide; it is a multifactorial genetic disease. Acetylation and deacetylation are major post-translational protein modifications that regulate gene expression and the activity of a myriad of oncoproteins. Aberrant deacetylase activity can promote or suppress tumorigenesis and cancer metastasis in different types of human cancers, including breast cancer. Sirtuin-1 (SIRT1) is a class-III histone deacetylase (HDAC) that deacetylates both histone and non-histone targets. The often-described ‘regulator of regulators’ is deeply implicated in apoptosis, gene regulation, genome maintenance, DNA repair, aging, and cancer development. However, despite the accumulated studies over the past decade, the role of SIRT1 in human breast cancer remains a subject of debate and controversy. The ambiguity surrounding the implications of SIRT1 in breast tumorigenesis stems from the discrepancy between studies, which have shown both tumor-suppressive and promoting functions of SIRT1. Furthermore, studies have shown that SIRT1 deficiency promotes or suppresses tumors in breast cancer, making it an attractive therapeutic target in cancer treatment. This review provides a comprehensive examination of the various implications of SIRT1 in breast cancer development and metastasis. We will also discuss the mechanisms underlying the conflicting roles of SIRT1, as well as its selective modulators, in breast carcinogenesis. MDPI 2018-10-30 /pmc/articles/PMC6266715/ /pubmed/30380732 http://dx.doi.org/10.3390/cancers10110409 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rifaï, Khaldoun
Idrissou, Mouhamed
Penault-Llorca, Frédérique
Bignon, Yves-Jean
Bernard-Gallon, Dominique
Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer
title Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer
title_full Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer
title_fullStr Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer
title_full_unstemmed Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer
title_short Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer
title_sort breaking down the contradictory roles of histone deacetylase sirt1 in human breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266715/
https://www.ncbi.nlm.nih.gov/pubmed/30380732
http://dx.doi.org/10.3390/cancers10110409
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