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Folate Receptor-Targeted and GSH-Responsive Carboxymethyl Chitosan Nanoparticles Containing Covalently Entrapped 6-Mercaptopurine for Enhanced Intracellular Drug Delivery in Leukemia

For enhanced intracellular accumulation of 6-mercaptopurine (6-MP) in leukemia, a folate receptor-targeted and glutathione (GSH)-responsive polymeric prodrug nanoparticle was made. The nanoparticles were prepared by conjugating 6-MP to carboxymethyl chitosan via a GSH-sensitive carbonyl vinyl sulfid...

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Detalles Bibliográficos
Autores principales:	Wei, Xuan, Liao, Jianhong, Davoudi, Zahra, Zheng, Hua, Chen, Jingru, Li, Dan, Xiong, Xiong, Yin, Yihua, Yu, Xiuxiang, Xiong, Jinghui, Wang, Qun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266736/ https://www.ncbi.nlm.nih.gov/pubmed/30413077 http://dx.doi.org/10.3390/md16110439

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