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The Crimping and Expanding Performance of Self-Expanding Polymeric Bioresorbable Stents: Experimental and Computational Investigation
Polymeric bioresorbable stents (PBRSs) are considered the most promising devices to treat cardiovascular diseases. However, the mechanical weakness still hampers their application. In general, PBRSs are crimped into small sheathes and re-expanded to support narrowed vessels during angioplasty. Accor...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266750/ https://www.ncbi.nlm.nih.gov/pubmed/30400381 http://dx.doi.org/10.3390/ma11112184 |
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author | Zhao, Fan Liu, Laijun Yang, Yang Wang, Fujun Wang, Lu |
author_facet | Zhao, Fan Liu, Laijun Yang, Yang Wang, Fujun Wang, Lu |
author_sort | Zhao, Fan |
collection | PubMed |
description | Polymeric bioresorbable stents (PBRSs) are considered the most promising devices to treat cardiovascular diseases. However, the mechanical weakness still hampers their application. In general, PBRSs are crimped into small sheathes and re-expanded to support narrowed vessels during angioplasty. Accordingly, one of the most significant requirements of PBRSs is to maintain mechanical efficacy after implantation. Although a little research has focused on commercial balloon-expanding PBRSs, a near-total lack has appeared on self-expanding PBRSs and their deformation mechanisms. In this work, self-expanding, composite polymeric bioresorbable stents (cPBRSs) incorporating poly(p-dioxanone) (PPDO) and polycaprolactone (PCL) yarns were produced and evaluated for their in vitro crimping and expanding potential. Furthermore, the polymer time-reliable viscoelastic effects of the structural and mechanical behavior of the cPBRSs were analyzed using computational simulations. Our results showed that the crimping process inevitably decreased the mechanical resistance of the cPBRSs, but that this could be offset by balloon dilatation. Moreover, deformation mechanisms at the yarn level were discussed, and yarns bonded in the crossings showed more viscous behavior; this property might help cPBRSs to maintain their structural integrity during implantation. |
format | Online Article Text |
id | pubmed-6266750 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62667502018-12-17 The Crimping and Expanding Performance of Self-Expanding Polymeric Bioresorbable Stents: Experimental and Computational Investigation Zhao, Fan Liu, Laijun Yang, Yang Wang, Fujun Wang, Lu Materials (Basel) Article Polymeric bioresorbable stents (PBRSs) are considered the most promising devices to treat cardiovascular diseases. However, the mechanical weakness still hampers their application. In general, PBRSs are crimped into small sheathes and re-expanded to support narrowed vessels during angioplasty. Accordingly, one of the most significant requirements of PBRSs is to maintain mechanical efficacy after implantation. Although a little research has focused on commercial balloon-expanding PBRSs, a near-total lack has appeared on self-expanding PBRSs and their deformation mechanisms. In this work, self-expanding, composite polymeric bioresorbable stents (cPBRSs) incorporating poly(p-dioxanone) (PPDO) and polycaprolactone (PCL) yarns were produced and evaluated for their in vitro crimping and expanding potential. Furthermore, the polymer time-reliable viscoelastic effects of the structural and mechanical behavior of the cPBRSs were analyzed using computational simulations. Our results showed that the crimping process inevitably decreased the mechanical resistance of the cPBRSs, but that this could be offset by balloon dilatation. Moreover, deformation mechanisms at the yarn level were discussed, and yarns bonded in the crossings showed more viscous behavior; this property might help cPBRSs to maintain their structural integrity during implantation. MDPI 2018-11-04 /pmc/articles/PMC6266750/ /pubmed/30400381 http://dx.doi.org/10.3390/ma11112184 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhao, Fan Liu, Laijun Yang, Yang Wang, Fujun Wang, Lu The Crimping and Expanding Performance of Self-Expanding Polymeric Bioresorbable Stents: Experimental and Computational Investigation |
title | The Crimping and Expanding Performance of Self-Expanding Polymeric Bioresorbable Stents: Experimental and Computational Investigation |
title_full | The Crimping and Expanding Performance of Self-Expanding Polymeric Bioresorbable Stents: Experimental and Computational Investigation |
title_fullStr | The Crimping and Expanding Performance of Self-Expanding Polymeric Bioresorbable Stents: Experimental and Computational Investigation |
title_full_unstemmed | The Crimping and Expanding Performance of Self-Expanding Polymeric Bioresorbable Stents: Experimental and Computational Investigation |
title_short | The Crimping and Expanding Performance of Self-Expanding Polymeric Bioresorbable Stents: Experimental and Computational Investigation |
title_sort | crimping and expanding performance of self-expanding polymeric bioresorbable stents: experimental and computational investigation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266750/ https://www.ncbi.nlm.nih.gov/pubmed/30400381 http://dx.doi.org/10.3390/ma11112184 |
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