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The Crimping and Expanding Performance of Self-Expanding Polymeric Bioresorbable Stents: Experimental and Computational Investigation

Polymeric bioresorbable stents (PBRSs) are considered the most promising devices to treat cardiovascular diseases. However, the mechanical weakness still hampers their application. In general, PBRSs are crimped into small sheathes and re-expanded to support narrowed vessels during angioplasty. Accor...

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Detalles Bibliográficos
Autores principales: Zhao, Fan, Liu, Laijun, Yang, Yang, Wang, Fujun, Wang, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266750/
https://www.ncbi.nlm.nih.gov/pubmed/30400381
http://dx.doi.org/10.3390/ma11112184
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author Zhao, Fan
Liu, Laijun
Yang, Yang
Wang, Fujun
Wang, Lu
author_facet Zhao, Fan
Liu, Laijun
Yang, Yang
Wang, Fujun
Wang, Lu
author_sort Zhao, Fan
collection PubMed
description Polymeric bioresorbable stents (PBRSs) are considered the most promising devices to treat cardiovascular diseases. However, the mechanical weakness still hampers their application. In general, PBRSs are crimped into small sheathes and re-expanded to support narrowed vessels during angioplasty. Accordingly, one of the most significant requirements of PBRSs is to maintain mechanical efficacy after implantation. Although a little research has focused on commercial balloon-expanding PBRSs, a near-total lack has appeared on self-expanding PBRSs and their deformation mechanisms. In this work, self-expanding, composite polymeric bioresorbable stents (cPBRSs) incorporating poly(p-dioxanone) (PPDO) and polycaprolactone (PCL) yarns were produced and evaluated for their in vitro crimping and expanding potential. Furthermore, the polymer time-reliable viscoelastic effects of the structural and mechanical behavior of the cPBRSs were analyzed using computational simulations. Our results showed that the crimping process inevitably decreased the mechanical resistance of the cPBRSs, but that this could be offset by balloon dilatation. Moreover, deformation mechanisms at the yarn level were discussed, and yarns bonded in the crossings showed more viscous behavior; this property might help cPBRSs to maintain their structural integrity during implantation.
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spelling pubmed-62667502018-12-17 The Crimping and Expanding Performance of Self-Expanding Polymeric Bioresorbable Stents: Experimental and Computational Investigation Zhao, Fan Liu, Laijun Yang, Yang Wang, Fujun Wang, Lu Materials (Basel) Article Polymeric bioresorbable stents (PBRSs) are considered the most promising devices to treat cardiovascular diseases. However, the mechanical weakness still hampers their application. In general, PBRSs are crimped into small sheathes and re-expanded to support narrowed vessels during angioplasty. Accordingly, one of the most significant requirements of PBRSs is to maintain mechanical efficacy after implantation. Although a little research has focused on commercial balloon-expanding PBRSs, a near-total lack has appeared on self-expanding PBRSs and their deformation mechanisms. In this work, self-expanding, composite polymeric bioresorbable stents (cPBRSs) incorporating poly(p-dioxanone) (PPDO) and polycaprolactone (PCL) yarns were produced and evaluated for their in vitro crimping and expanding potential. Furthermore, the polymer time-reliable viscoelastic effects of the structural and mechanical behavior of the cPBRSs were analyzed using computational simulations. Our results showed that the crimping process inevitably decreased the mechanical resistance of the cPBRSs, but that this could be offset by balloon dilatation. Moreover, deformation mechanisms at the yarn level were discussed, and yarns bonded in the crossings showed more viscous behavior; this property might help cPBRSs to maintain their structural integrity during implantation. MDPI 2018-11-04 /pmc/articles/PMC6266750/ /pubmed/30400381 http://dx.doi.org/10.3390/ma11112184 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhao, Fan
Liu, Laijun
Yang, Yang
Wang, Fujun
Wang, Lu
The Crimping and Expanding Performance of Self-Expanding Polymeric Bioresorbable Stents: Experimental and Computational Investigation
title The Crimping and Expanding Performance of Self-Expanding Polymeric Bioresorbable Stents: Experimental and Computational Investigation
title_full The Crimping and Expanding Performance of Self-Expanding Polymeric Bioresorbable Stents: Experimental and Computational Investigation
title_fullStr The Crimping and Expanding Performance of Self-Expanding Polymeric Bioresorbable Stents: Experimental and Computational Investigation
title_full_unstemmed The Crimping and Expanding Performance of Self-Expanding Polymeric Bioresorbable Stents: Experimental and Computational Investigation
title_short The Crimping and Expanding Performance of Self-Expanding Polymeric Bioresorbable Stents: Experimental and Computational Investigation
title_sort crimping and expanding performance of self-expanding polymeric bioresorbable stents: experimental and computational investigation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266750/
https://www.ncbi.nlm.nih.gov/pubmed/30400381
http://dx.doi.org/10.3390/ma11112184
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