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Multifunctional Platform Based on Electroactive Polymers and Silica Nanoparticles for Tissue Engineering Applications

Poly(vinylidene fluoride) nanocomposites processed with different morphologies, such as porous and non-porous films and fibres, have been prepared with silica nanoparticles (SiNPs) of varying diameter (17, 100, 160 and 300 nm), which in turn have encapsulated perylenediimide (PDI), a fluorescent mol...

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Autores principales: Ribeiro, Sylvie, Ribeiro, Tânia, Ribeiro, Clarisse, Correia, Daniela M., Farinha, José P. Sequeira, Gomes, Andreia Castro, Baleizão, Carlos, Lanceros-Méndez, Senentxu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266809/
https://www.ncbi.nlm.nih.gov/pubmed/30423943
http://dx.doi.org/10.3390/nano8110933
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author Ribeiro, Sylvie
Ribeiro, Tânia
Ribeiro, Clarisse
Correia, Daniela M.
Farinha, José P. Sequeira
Gomes, Andreia Castro
Baleizão, Carlos
Lanceros-Méndez, Senentxu
author_facet Ribeiro, Sylvie
Ribeiro, Tânia
Ribeiro, Clarisse
Correia, Daniela M.
Farinha, José P. Sequeira
Gomes, Andreia Castro
Baleizão, Carlos
Lanceros-Méndez, Senentxu
author_sort Ribeiro, Sylvie
collection PubMed
description Poly(vinylidene fluoride) nanocomposites processed with different morphologies, such as porous and non-porous films and fibres, have been prepared with silica nanoparticles (SiNPs) of varying diameter (17, 100, 160 and 300 nm), which in turn have encapsulated perylenediimide (PDI), a fluorescent molecule. The structural, morphological, optical, thermal, and mechanical properties of the nanocomposites, with SiNP filler concentration up to 16 wt %, were evaluated. Furthermore, cytotoxicity and cell proliferation studies were performed. All SiNPs are negatively charged independently of the pH and more stable from pH 5 upwards. The introduction of SiNPs within the polymer matrix increases the contact angle independently of the nanoparticle diameter. Moreover, the smallest ones (17 nm) also improve the PVDF Young’s modulus. The filler diameter, physico-chemical, thermal and mechanical properties of the polymer matrix were not significantly affected. Finally, the SiNPs’ inclusion does not induce cytotoxicity in murine myoblasts (C2C12) after 72 h of contact and proliferation studies reveal that the prepared composites represent a suitable platform for tissue engineering applications, as they allow us to combine the biocompatibility and piezoelectricity of the polymer with the possible functionalization and drug encapsulation and release of the SiNP.
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spelling pubmed-62668092018-12-06 Multifunctional Platform Based on Electroactive Polymers and Silica Nanoparticles for Tissue Engineering Applications Ribeiro, Sylvie Ribeiro, Tânia Ribeiro, Clarisse Correia, Daniela M. Farinha, José P. Sequeira Gomes, Andreia Castro Baleizão, Carlos Lanceros-Méndez, Senentxu Nanomaterials (Basel) Article Poly(vinylidene fluoride) nanocomposites processed with different morphologies, such as porous and non-porous films and fibres, have been prepared with silica nanoparticles (SiNPs) of varying diameter (17, 100, 160 and 300 nm), which in turn have encapsulated perylenediimide (PDI), a fluorescent molecule. The structural, morphological, optical, thermal, and mechanical properties of the nanocomposites, with SiNP filler concentration up to 16 wt %, were evaluated. Furthermore, cytotoxicity and cell proliferation studies were performed. All SiNPs are negatively charged independently of the pH and more stable from pH 5 upwards. The introduction of SiNPs within the polymer matrix increases the contact angle independently of the nanoparticle diameter. Moreover, the smallest ones (17 nm) also improve the PVDF Young’s modulus. The filler diameter, physico-chemical, thermal and mechanical properties of the polymer matrix were not significantly affected. Finally, the SiNPs’ inclusion does not induce cytotoxicity in murine myoblasts (C2C12) after 72 h of contact and proliferation studies reveal that the prepared composites represent a suitable platform for tissue engineering applications, as they allow us to combine the biocompatibility and piezoelectricity of the polymer with the possible functionalization and drug encapsulation and release of the SiNP. MDPI 2018-11-09 /pmc/articles/PMC6266809/ /pubmed/30423943 http://dx.doi.org/10.3390/nano8110933 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ribeiro, Sylvie
Ribeiro, Tânia
Ribeiro, Clarisse
Correia, Daniela M.
Farinha, José P. Sequeira
Gomes, Andreia Castro
Baleizão, Carlos
Lanceros-Méndez, Senentxu
Multifunctional Platform Based on Electroactive Polymers and Silica Nanoparticles for Tissue Engineering Applications
title Multifunctional Platform Based on Electroactive Polymers and Silica Nanoparticles for Tissue Engineering Applications
title_full Multifunctional Platform Based on Electroactive Polymers and Silica Nanoparticles for Tissue Engineering Applications
title_fullStr Multifunctional Platform Based on Electroactive Polymers and Silica Nanoparticles for Tissue Engineering Applications
title_full_unstemmed Multifunctional Platform Based on Electroactive Polymers and Silica Nanoparticles for Tissue Engineering Applications
title_short Multifunctional Platform Based on Electroactive Polymers and Silica Nanoparticles for Tissue Engineering Applications
title_sort multifunctional platform based on electroactive polymers and silica nanoparticles for tissue engineering applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266809/
https://www.ncbi.nlm.nih.gov/pubmed/30423943
http://dx.doi.org/10.3390/nano8110933
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