Aptamer Chimeras for Therapeutic Delivery: The Challenging Perspectives

Nucleic acid-based aptamers have emerged as efficient delivery carriers of therapeutics. Thanks to their unique features, they can be, to date, considered one of the best targeting moieties, allowing the specific recognition of diseased cells and avoiding unwanted off-target effects on healthy tissu...

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Detalles Bibliográficos
Autores principales: Esposito, Carla Lucia, Catuogno, Silvia, Condorelli, Gerolama, Ungaro, Paola, de Franciscis, Vittorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266988/
https://www.ncbi.nlm.nih.gov/pubmed/30384431
http://dx.doi.org/10.3390/genes9110529
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author Esposito, Carla Lucia
Catuogno, Silvia
Condorelli, Gerolama
Ungaro, Paola
de Franciscis, Vittorio
author_facet Esposito, Carla Lucia
Catuogno, Silvia
Condorelli, Gerolama
Ungaro, Paola
de Franciscis, Vittorio
author_sort Esposito, Carla Lucia
collection PubMed
description Nucleic acid-based aptamers have emerged as efficient delivery carriers of therapeutics. Thanks to their unique features, they can be, to date, considered one of the best targeting moieties, allowing the specific recognition of diseased cells and avoiding unwanted off-target effects on healthy tissues. In this review, we revise the most recent contributes on bispecific and multifunctional aptamer therapeutic chimeras. We will discuss key examples of aptamer-mediated delivery of nucleic acid and peptide-based therapeutics underlying their great potentiality and versatility. Achieved objectives and challenges will be highlighted as well.
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spelling pubmed-62669882018-12-13 Aptamer Chimeras for Therapeutic Delivery: The Challenging Perspectives Esposito, Carla Lucia Catuogno, Silvia Condorelli, Gerolama Ungaro, Paola de Franciscis, Vittorio Genes (Basel) Review Nucleic acid-based aptamers have emerged as efficient delivery carriers of therapeutics. Thanks to their unique features, they can be, to date, considered one of the best targeting moieties, allowing the specific recognition of diseased cells and avoiding unwanted off-target effects on healthy tissues. In this review, we revise the most recent contributes on bispecific and multifunctional aptamer therapeutic chimeras. We will discuss key examples of aptamer-mediated delivery of nucleic acid and peptide-based therapeutics underlying their great potentiality and versatility. Achieved objectives and challenges will be highlighted as well. MDPI 2018-10-31 /pmc/articles/PMC6266988/ /pubmed/30384431 http://dx.doi.org/10.3390/genes9110529 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Esposito, Carla Lucia
Catuogno, Silvia
Condorelli, Gerolama
Ungaro, Paola
de Franciscis, Vittorio
Aptamer Chimeras for Therapeutic Delivery: The Challenging Perspectives
title Aptamer Chimeras for Therapeutic Delivery: The Challenging Perspectives
title_full Aptamer Chimeras for Therapeutic Delivery: The Challenging Perspectives
title_fullStr Aptamer Chimeras for Therapeutic Delivery: The Challenging Perspectives
title_full_unstemmed Aptamer Chimeras for Therapeutic Delivery: The Challenging Perspectives
title_short Aptamer Chimeras for Therapeutic Delivery: The Challenging Perspectives
title_sort aptamer chimeras for therapeutic delivery: the challenging perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266988/
https://www.ncbi.nlm.nih.gov/pubmed/30384431
http://dx.doi.org/10.3390/genes9110529
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