Oxysterols from a Marine Sponge Inflatella sp. and Their Action in 6-Hydroxydopamine-Induced Cell Model of Parkinson’s Disease

Four new oxysterols 1–4 along with previously known oxygenated sterols 5–14 were isolated from the sponge Inflatella sp., collected from the Sea of Okhotsk. Structures of 1–4 were elucidated by the detailed NMR spectroscopic and mass-spectrometric analyses as well as by comparison of the correspondi...

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Autores principales: Kolesnikova, Sophia A., Lyakhova, Ekaterina G., Kalinovsky, Anatoly I., Popov, Roman S., Yurchenko, Ekaterina A., Stonik, Valentin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267020/
https://www.ncbi.nlm.nih.gov/pubmed/30469397
http://dx.doi.org/10.3390/md16110458
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author Kolesnikova, Sophia A.
Lyakhova, Ekaterina G.
Kalinovsky, Anatoly I.
Popov, Roman S.
Yurchenko, Ekaterina A.
Stonik, Valentin A.
author_facet Kolesnikova, Sophia A.
Lyakhova, Ekaterina G.
Kalinovsky, Anatoly I.
Popov, Roman S.
Yurchenko, Ekaterina A.
Stonik, Valentin A.
author_sort Kolesnikova, Sophia A.
collection PubMed
description Four new oxysterols 1–4 along with previously known oxygenated sterols 5–14 were isolated from the sponge Inflatella sp., collected from the Sea of Okhotsk. Structures of 1–4 were elucidated by the detailed NMR spectroscopic and mass-spectrometric analyses as well as by comparison of the corresponding experimental data with those reported in literature. The influence of compounds 1–14 on the viability of neuronal Neuro2a cells treated by 6-hydroxydopamine and reactive oxygen species (ROS) formation in these cells was investigated.
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spelling pubmed-62670202018-12-06 Oxysterols from a Marine Sponge Inflatella sp. and Their Action in 6-Hydroxydopamine-Induced Cell Model of Parkinson’s Disease Kolesnikova, Sophia A. Lyakhova, Ekaterina G. Kalinovsky, Anatoly I. Popov, Roman S. Yurchenko, Ekaterina A. Stonik, Valentin A. Mar Drugs Article Four new oxysterols 1–4 along with previously known oxygenated sterols 5–14 were isolated from the sponge Inflatella sp., collected from the Sea of Okhotsk. Structures of 1–4 were elucidated by the detailed NMR spectroscopic and mass-spectrometric analyses as well as by comparison of the corresponding experimental data with those reported in literature. The influence of compounds 1–14 on the viability of neuronal Neuro2a cells treated by 6-hydroxydopamine and reactive oxygen species (ROS) formation in these cells was investigated. MDPI 2018-11-21 /pmc/articles/PMC6267020/ /pubmed/30469397 http://dx.doi.org/10.3390/md16110458 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kolesnikova, Sophia A.
Lyakhova, Ekaterina G.
Kalinovsky, Anatoly I.
Popov, Roman S.
Yurchenko, Ekaterina A.
Stonik, Valentin A.
Oxysterols from a Marine Sponge Inflatella sp. and Their Action in 6-Hydroxydopamine-Induced Cell Model of Parkinson’s Disease
title Oxysterols from a Marine Sponge Inflatella sp. and Their Action in 6-Hydroxydopamine-Induced Cell Model of Parkinson’s Disease
title_full Oxysterols from a Marine Sponge Inflatella sp. and Their Action in 6-Hydroxydopamine-Induced Cell Model of Parkinson’s Disease
title_fullStr Oxysterols from a Marine Sponge Inflatella sp. and Their Action in 6-Hydroxydopamine-Induced Cell Model of Parkinson’s Disease
title_full_unstemmed Oxysterols from a Marine Sponge Inflatella sp. and Their Action in 6-Hydroxydopamine-Induced Cell Model of Parkinson’s Disease
title_short Oxysterols from a Marine Sponge Inflatella sp. and Their Action in 6-Hydroxydopamine-Induced Cell Model of Parkinson’s Disease
title_sort oxysterols from a marine sponge inflatella sp. and their action in 6-hydroxydopamine-induced cell model of parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267020/
https://www.ncbi.nlm.nih.gov/pubmed/30469397
http://dx.doi.org/10.3390/md16110458
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