Cargando…
Correlation of Nutritional Indices on Admission to the Coronary Intensive Care Unit with the Development of Delirium
Background: Delirium is a common occurrence in patients admitted to the intensive care unit and is related to mortality and morbidity. Malnutrition is a predisposing factor for the development of delirium. Nevertheless, whether the nutritional status on admission anticipates the development of delir...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267104/ https://www.ncbi.nlm.nih.gov/pubmed/30413062 http://dx.doi.org/10.3390/nu10111712 |
_version_ | 1783375990438756352 |
---|---|
author | Sugita, Yurina Miyazaki, Tetsuro Shimada, Kazunori Shimizu, Megumi Kunimoto, Mitsuhiro Ouchi, Shohei Aikawa, Tatsuro Kadoguchi, Tomoyasu Kawaguchi, Yuko Shiozawa, Tomoyuki Takasu, Kiyoshi Hiki, Masaru Takahashi, Shuhei Sumiyoshi, Katsuhiko Iwata, Hiroshi Daida, Hiroyuki |
author_facet | Sugita, Yurina Miyazaki, Tetsuro Shimada, Kazunori Shimizu, Megumi Kunimoto, Mitsuhiro Ouchi, Shohei Aikawa, Tatsuro Kadoguchi, Tomoyasu Kawaguchi, Yuko Shiozawa, Tomoyuki Takasu, Kiyoshi Hiki, Masaru Takahashi, Shuhei Sumiyoshi, Katsuhiko Iwata, Hiroshi Daida, Hiroyuki |
author_sort | Sugita, Yurina |
collection | PubMed |
description | Background: Delirium is a common occurrence in patients admitted to the intensive care unit and is related to mortality and morbidity. Malnutrition is a predisposing factor for the development of delirium. Nevertheless, whether the nutritional status on admission anticipates the development of delirium in patients with acute cardiovascular diseases remains unknown. Objective: This study aims to assess the correlation between the nutritional status on admission using the nutritional index and the development of delirium in the coronary intensive care unit. Design: We examined 653 consecutive patients (mean age: 70 ± 14 years) admitted to the coronary intensive care unit of Juntendo University Hospital between January 2015 and December 2016. We evaluated three nutritional indices frequently used to assess the nutritional status, i.e., Geriatric Nutritional Risk Index (GNRI), Prognostic Nutritional Index (PNI), and Controlling Nutritional Status (CONUT). We defined delirium as patients with a delirium score >4 using the Intensive Care Delirium Screening Checklist. Results: Delirium was present in 58 patients. All nutritional indices exhibited a tendency for malnutrition in the delirium group compared with the non-delirium group (GNRI, 86.5 ± 9.38 versus 91.6 ± 9.89; PNI, 36.4 ± 6.95 versus 41.6 ± 7.62; CONUT, 5.88 ± 3.00 versus 3.61 ± 2.56; for all, p < 0.001). Furthermore, the maximum delirium score increased progressively from the low- to the high-risk group, as evaluated by each nutritional index (GNRI, PNI, CONUT; for all, p < 0.001). A multivariate analysis revealed that the PNI and CONUT were independent risk factors for the occurrence of delirium. Conclusions: A marked correlation exists between the nutritional index on admission, especially PNI and CONUT, and the development of delirium in patients with acute cardiovascular diseases, suggesting that malnutrition assessment upon admission could help identify patients at high risk of developing delirium. |
format | Online Article Text |
id | pubmed-6267104 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62671042018-12-06 Correlation of Nutritional Indices on Admission to the Coronary Intensive Care Unit with the Development of Delirium Sugita, Yurina Miyazaki, Tetsuro Shimada, Kazunori Shimizu, Megumi Kunimoto, Mitsuhiro Ouchi, Shohei Aikawa, Tatsuro Kadoguchi, Tomoyasu Kawaguchi, Yuko Shiozawa, Tomoyuki Takasu, Kiyoshi Hiki, Masaru Takahashi, Shuhei Sumiyoshi, Katsuhiko Iwata, Hiroshi Daida, Hiroyuki Nutrients Article Background: Delirium is a common occurrence in patients admitted to the intensive care unit and is related to mortality and morbidity. Malnutrition is a predisposing factor for the development of delirium. Nevertheless, whether the nutritional status on admission anticipates the development of delirium in patients with acute cardiovascular diseases remains unknown. Objective: This study aims to assess the correlation between the nutritional status on admission using the nutritional index and the development of delirium in the coronary intensive care unit. Design: We examined 653 consecutive patients (mean age: 70 ± 14 years) admitted to the coronary intensive care unit of Juntendo University Hospital between January 2015 and December 2016. We evaluated three nutritional indices frequently used to assess the nutritional status, i.e., Geriatric Nutritional Risk Index (GNRI), Prognostic Nutritional Index (PNI), and Controlling Nutritional Status (CONUT). We defined delirium as patients with a delirium score >4 using the Intensive Care Delirium Screening Checklist. Results: Delirium was present in 58 patients. All nutritional indices exhibited a tendency for malnutrition in the delirium group compared with the non-delirium group (GNRI, 86.5 ± 9.38 versus 91.6 ± 9.89; PNI, 36.4 ± 6.95 versus 41.6 ± 7.62; CONUT, 5.88 ± 3.00 versus 3.61 ± 2.56; for all, p < 0.001). Furthermore, the maximum delirium score increased progressively from the low- to the high-risk group, as evaluated by each nutritional index (GNRI, PNI, CONUT; for all, p < 0.001). A multivariate analysis revealed that the PNI and CONUT were independent risk factors for the occurrence of delirium. Conclusions: A marked correlation exists between the nutritional index on admission, especially PNI and CONUT, and the development of delirium in patients with acute cardiovascular diseases, suggesting that malnutrition assessment upon admission could help identify patients at high risk of developing delirium. MDPI 2018-11-08 /pmc/articles/PMC6267104/ /pubmed/30413062 http://dx.doi.org/10.3390/nu10111712 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sugita, Yurina Miyazaki, Tetsuro Shimada, Kazunori Shimizu, Megumi Kunimoto, Mitsuhiro Ouchi, Shohei Aikawa, Tatsuro Kadoguchi, Tomoyasu Kawaguchi, Yuko Shiozawa, Tomoyuki Takasu, Kiyoshi Hiki, Masaru Takahashi, Shuhei Sumiyoshi, Katsuhiko Iwata, Hiroshi Daida, Hiroyuki Correlation of Nutritional Indices on Admission to the Coronary Intensive Care Unit with the Development of Delirium |
title | Correlation of Nutritional Indices on Admission to the Coronary Intensive Care Unit with the Development of Delirium |
title_full | Correlation of Nutritional Indices on Admission to the Coronary Intensive Care Unit with the Development of Delirium |
title_fullStr | Correlation of Nutritional Indices on Admission to the Coronary Intensive Care Unit with the Development of Delirium |
title_full_unstemmed | Correlation of Nutritional Indices on Admission to the Coronary Intensive Care Unit with the Development of Delirium |
title_short | Correlation of Nutritional Indices on Admission to the Coronary Intensive Care Unit with the Development of Delirium |
title_sort | correlation of nutritional indices on admission to the coronary intensive care unit with the development of delirium |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267104/ https://www.ncbi.nlm.nih.gov/pubmed/30413062 http://dx.doi.org/10.3390/nu10111712 |
work_keys_str_mv | AT sugitayurina correlationofnutritionalindicesonadmissiontothecoronaryintensivecareunitwiththedevelopmentofdelirium AT miyazakitetsuro correlationofnutritionalindicesonadmissiontothecoronaryintensivecareunitwiththedevelopmentofdelirium AT shimadakazunori correlationofnutritionalindicesonadmissiontothecoronaryintensivecareunitwiththedevelopmentofdelirium AT shimizumegumi correlationofnutritionalindicesonadmissiontothecoronaryintensivecareunitwiththedevelopmentofdelirium AT kunimotomitsuhiro correlationofnutritionalindicesonadmissiontothecoronaryintensivecareunitwiththedevelopmentofdelirium AT ouchishohei correlationofnutritionalindicesonadmissiontothecoronaryintensivecareunitwiththedevelopmentofdelirium AT aikawatatsuro correlationofnutritionalindicesonadmissiontothecoronaryintensivecareunitwiththedevelopmentofdelirium AT kadoguchitomoyasu correlationofnutritionalindicesonadmissiontothecoronaryintensivecareunitwiththedevelopmentofdelirium AT kawaguchiyuko correlationofnutritionalindicesonadmissiontothecoronaryintensivecareunitwiththedevelopmentofdelirium AT shiozawatomoyuki correlationofnutritionalindicesonadmissiontothecoronaryintensivecareunitwiththedevelopmentofdelirium AT takasukiyoshi correlationofnutritionalindicesonadmissiontothecoronaryintensivecareunitwiththedevelopmentofdelirium AT hikimasaru correlationofnutritionalindicesonadmissiontothecoronaryintensivecareunitwiththedevelopmentofdelirium AT takahashishuhei correlationofnutritionalindicesonadmissiontothecoronaryintensivecareunitwiththedevelopmentofdelirium AT sumiyoshikatsuhiko correlationofnutritionalindicesonadmissiontothecoronaryintensivecareunitwiththedevelopmentofdelirium AT iwatahiroshi correlationofnutritionalindicesonadmissiontothecoronaryintensivecareunitwiththedevelopmentofdelirium AT daidahiroyuki correlationofnutritionalindicesonadmissiontothecoronaryintensivecareunitwiththedevelopmentofdelirium |