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Effects of virtual tube current reduction and sparse sampling on MDCT-based femoral BMD measurements

SUMMARY: This study investigates the impact of tube current reduction and sparse sampling on femoral bone mineral density (BMD) measurements derived from multi-detector computed tomography (MDCT). The application of sparse sampling led to robust and clinically acceptable BMD measurements. In contras...

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Autores principales: Sollmann, N., Mei, K., Schwaiger, B.J., Gersing, A.S., Kopp, F.K., Bippus, R., Maegerlein, C., Zimmer, C., Rummeny, E.J., Kirschke, J.S., Noël, P.B., Baum, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer London 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267136/
https://www.ncbi.nlm.nih.gov/pubmed/30143850
http://dx.doi.org/10.1007/s00198-018-4675-6
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author Sollmann, N.
Mei, K.
Schwaiger, B.J.
Gersing, A.S.
Kopp, F.K.
Bippus, R.
Maegerlein, C.
Zimmer, C.
Rummeny, E.J.
Kirschke, J.S.
Noël, P.B.
Baum, T.
author_facet Sollmann, N.
Mei, K.
Schwaiger, B.J.
Gersing, A.S.
Kopp, F.K.
Bippus, R.
Maegerlein, C.
Zimmer, C.
Rummeny, E.J.
Kirschke, J.S.
Noël, P.B.
Baum, T.
author_sort Sollmann, N.
collection PubMed
description SUMMARY: This study investigates the impact of tube current reduction and sparse sampling on femoral bone mineral density (BMD) measurements derived from multi-detector computed tomography (MDCT). The application of sparse sampling led to robust and clinically acceptable BMD measurements. In contrast, BMD measurements derived from MDCT with virtually reduced tube currents showed a considerable increase when compared to original data. INTRODUCTION: The study aims to evaluate the effects of radiation dose reduction by using virtual reduction of tube current or sparse sampling combined with standard filtered back projection (FBP) and statistical iterative reconstruction (SIR) on femoral bone mineral density (BMD) measurements derived from multi-detector computed tomography (MDCT). METHODS: In routine MDCT scans of 41 subjects (65.9% men; age 69.3 ± 10.1 years), reduced radiation doses were simulated by lowering tube currents and applying sparse sampling (50, 25, and 10% of the original tube current and projections, respectively). Images were reconstructed using FBP and SIR. BMD values were assessed in the femoral neck and compared between the different dose levels, numbers of projections, and image reconstruction approaches. RESULTS: Compared to full-dose MDCT, virtual lowering of the tube current by applying our simulation algorithm resulted in increases in BMD values for both FBP (up to a relative change of 32.5%) and SIR (up to a relative change of 32.3%). In contrast, the application of sparse sampling with a reduction down to 10% of projections showed robust BMD values, with clinically acceptable relative changes of up to 0.5% (FBP) and 0.7% (SIR). CONCLUSIONS: Our simulations, which still require clinical validation, indicate that reductions down to ultra-low tube currents have a significant impact on MDCT-based femoral BMD measurements. In contrast, the application of sparse-sampled MDCT seems a promising future clinical option that may enable a significant reduction of the radiation dose without considerable changes of BMD values.
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spelling pubmed-62671362018-12-11 Effects of virtual tube current reduction and sparse sampling on MDCT-based femoral BMD measurements Sollmann, N. Mei, K. Schwaiger, B.J. Gersing, A.S. Kopp, F.K. Bippus, R. Maegerlein, C. Zimmer, C. Rummeny, E.J. Kirschke, J.S. Noël, P.B. Baum, T. Osteoporos Int Original Article SUMMARY: This study investigates the impact of tube current reduction and sparse sampling on femoral bone mineral density (BMD) measurements derived from multi-detector computed tomography (MDCT). The application of sparse sampling led to robust and clinically acceptable BMD measurements. In contrast, BMD measurements derived from MDCT with virtually reduced tube currents showed a considerable increase when compared to original data. INTRODUCTION: The study aims to evaluate the effects of radiation dose reduction by using virtual reduction of tube current or sparse sampling combined with standard filtered back projection (FBP) and statistical iterative reconstruction (SIR) on femoral bone mineral density (BMD) measurements derived from multi-detector computed tomography (MDCT). METHODS: In routine MDCT scans of 41 subjects (65.9% men; age 69.3 ± 10.1 years), reduced radiation doses were simulated by lowering tube currents and applying sparse sampling (50, 25, and 10% of the original tube current and projections, respectively). Images were reconstructed using FBP and SIR. BMD values were assessed in the femoral neck and compared between the different dose levels, numbers of projections, and image reconstruction approaches. RESULTS: Compared to full-dose MDCT, virtual lowering of the tube current by applying our simulation algorithm resulted in increases in BMD values for both FBP (up to a relative change of 32.5%) and SIR (up to a relative change of 32.3%). In contrast, the application of sparse sampling with a reduction down to 10% of projections showed robust BMD values, with clinically acceptable relative changes of up to 0.5% (FBP) and 0.7% (SIR). CONCLUSIONS: Our simulations, which still require clinical validation, indicate that reductions down to ultra-low tube currents have a significant impact on MDCT-based femoral BMD measurements. In contrast, the application of sparse-sampled MDCT seems a promising future clinical option that may enable a significant reduction of the radiation dose without considerable changes of BMD values. Springer London 2018-08-24 2018 /pmc/articles/PMC6267136/ /pubmed/30143850 http://dx.doi.org/10.1007/s00198-018-4675-6 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Sollmann, N.
Mei, K.
Schwaiger, B.J.
Gersing, A.S.
Kopp, F.K.
Bippus, R.
Maegerlein, C.
Zimmer, C.
Rummeny, E.J.
Kirschke, J.S.
Noël, P.B.
Baum, T.
Effects of virtual tube current reduction and sparse sampling on MDCT-based femoral BMD measurements
title Effects of virtual tube current reduction and sparse sampling on MDCT-based femoral BMD measurements
title_full Effects of virtual tube current reduction and sparse sampling on MDCT-based femoral BMD measurements
title_fullStr Effects of virtual tube current reduction and sparse sampling on MDCT-based femoral BMD measurements
title_full_unstemmed Effects of virtual tube current reduction and sparse sampling on MDCT-based femoral BMD measurements
title_short Effects of virtual tube current reduction and sparse sampling on MDCT-based femoral BMD measurements
title_sort effects of virtual tube current reduction and sparse sampling on mdct-based femoral bmd measurements
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267136/
https://www.ncbi.nlm.nih.gov/pubmed/30143850
http://dx.doi.org/10.1007/s00198-018-4675-6
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