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Adaptation and Validation of the Korean Version of the Urticaria Control Test and Its Correlation With Salivary Cortisone

PURPOSE: Frequent changes in chronic urticaria (CU) activity over time can cause psychological stress, which also serves as a trigger of CU. To measure the control status of CU, the Urticaria Control Test (UCT) was developed in Germany. This study aimed to investigate the validity, reliability and r...

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Autores principales: Lee, Ji-Ho, Bae, Yoon Ju, Lee, So-Hee, Kim, Su-Chin, Lee, Hyun-Young, Ban, Ga-Young, Shin, Yoo Seob, Park, Hae-Sim, Kratzsch, Juergen, Ye, Young-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267182/
https://www.ncbi.nlm.nih.gov/pubmed/30479077
http://dx.doi.org/10.4168/aair.2019.11.1.55
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author Lee, Ji-Ho
Bae, Yoon Ju
Lee, So-Hee
Kim, Su-Chin
Lee, Hyun-Young
Ban, Ga-Young
Shin, Yoo Seob
Park, Hae-Sim
Kratzsch, Juergen
Ye, Young-Min
author_facet Lee, Ji-Ho
Bae, Yoon Ju
Lee, So-Hee
Kim, Su-Chin
Lee, Hyun-Young
Ban, Ga-Young
Shin, Yoo Seob
Park, Hae-Sim
Kratzsch, Juergen
Ye, Young-Min
author_sort Lee, Ji-Ho
collection PubMed
description PURPOSE: Frequent changes in chronic urticaria (CU) activity over time can cause psychological stress, which also serves as a trigger of CU. To measure the control status of CU, the Urticaria Control Test (UCT) was developed in Germany. This study aimed to investigate the validity, reliability and responsiveness to changes in CU for the Korean version of the UCT (K-UCT) and its relation with salivary cortisol and cortisone levels. METHODS: Linguistic adaptation of the UCT into Korean was conducted. A total of 96 CU patients were enrolled, and 80 of them completed the study. The K-UCT and other outcome scores for CU were measured and repeated after 4 weeks of treatment. Control status was classified by physicians into well-controlled, partly-controlled, and uncontrolled CU. Salivary cortisol and cortisone were measured by liquid chromatography-tandem mass spectrometry. RESULTS: Excellent internal consistency and intra-class reliability were obtained. Strong correlations between the K-UCT and disease severity, reflected in the Urticaria Activity Score (UAS)/global assessment of urticaria control by physicians/patient assessment of symptom severity/CU-specific quality of life were noted. K-UCT scores ≥12 were found to be optimal for determining well-controlled CU (sensitivity, 75.0%; specificity, 758%; area under the curve, 0.824). Perceived stress scale scores were significantly correlated with the UAS and the K-UCT. Salivary cortisone levels were significantly correlated with K-UCT (r = 0.308, P = 0.009) and differed significantly according to control status determined by a K-UCT ≥12. CONCLUSIONS: This study demonstrated that the K-UCT can be a valid instrument with which to gauge CU control status in Korean patients. Further studies are needed to validate salivary cortisone as a biomarker for CU control.
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spelling pubmed-62671822019-01-01 Adaptation and Validation of the Korean Version of the Urticaria Control Test and Its Correlation With Salivary Cortisone Lee, Ji-Ho Bae, Yoon Ju Lee, So-Hee Kim, Su-Chin Lee, Hyun-Young Ban, Ga-Young Shin, Yoo Seob Park, Hae-Sim Kratzsch, Juergen Ye, Young-Min Allergy Asthma Immunol Res Original Article PURPOSE: Frequent changes in chronic urticaria (CU) activity over time can cause psychological stress, which also serves as a trigger of CU. To measure the control status of CU, the Urticaria Control Test (UCT) was developed in Germany. This study aimed to investigate the validity, reliability and responsiveness to changes in CU for the Korean version of the UCT (K-UCT) and its relation with salivary cortisol and cortisone levels. METHODS: Linguistic adaptation of the UCT into Korean was conducted. A total of 96 CU patients were enrolled, and 80 of them completed the study. The K-UCT and other outcome scores for CU were measured and repeated after 4 weeks of treatment. Control status was classified by physicians into well-controlled, partly-controlled, and uncontrolled CU. Salivary cortisol and cortisone were measured by liquid chromatography-tandem mass spectrometry. RESULTS: Excellent internal consistency and intra-class reliability were obtained. Strong correlations between the K-UCT and disease severity, reflected in the Urticaria Activity Score (UAS)/global assessment of urticaria control by physicians/patient assessment of symptom severity/CU-specific quality of life were noted. K-UCT scores ≥12 were found to be optimal for determining well-controlled CU (sensitivity, 75.0%; specificity, 758%; area under the curve, 0.824). Perceived stress scale scores were significantly correlated with the UAS and the K-UCT. Salivary cortisone levels were significantly correlated with K-UCT (r = 0.308, P = 0.009) and differed significantly according to control status determined by a K-UCT ≥12. CONCLUSIONS: This study demonstrated that the K-UCT can be a valid instrument with which to gauge CU control status in Korean patients. Further studies are needed to validate salivary cortisone as a biomarker for CU control. The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2018-09-27 /pmc/articles/PMC6267182/ /pubmed/30479077 http://dx.doi.org/10.4168/aair.2019.11.1.55 Text en Copyright © 2019 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Ji-Ho
Bae, Yoon Ju
Lee, So-Hee
Kim, Su-Chin
Lee, Hyun-Young
Ban, Ga-Young
Shin, Yoo Seob
Park, Hae-Sim
Kratzsch, Juergen
Ye, Young-Min
Adaptation and Validation of the Korean Version of the Urticaria Control Test and Its Correlation With Salivary Cortisone
title Adaptation and Validation of the Korean Version of the Urticaria Control Test and Its Correlation With Salivary Cortisone
title_full Adaptation and Validation of the Korean Version of the Urticaria Control Test and Its Correlation With Salivary Cortisone
title_fullStr Adaptation and Validation of the Korean Version of the Urticaria Control Test and Its Correlation With Salivary Cortisone
title_full_unstemmed Adaptation and Validation of the Korean Version of the Urticaria Control Test and Its Correlation With Salivary Cortisone
title_short Adaptation and Validation of the Korean Version of the Urticaria Control Test and Its Correlation With Salivary Cortisone
title_sort adaptation and validation of the korean version of the urticaria control test and its correlation with salivary cortisone
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267182/
https://www.ncbi.nlm.nih.gov/pubmed/30479077
http://dx.doi.org/10.4168/aair.2019.11.1.55
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