Effects of Ser47-Point Mutation on Conformation Structure and Allergenicity of the Allergen of Der p 2, a Major House Dust Mite Allergen

PURPOSE: Hypoallergenic recombinant Der p 2 has been produced by various genetic manipulations, but mutation of a naturally polymorphic amino acid residue known to affect IgE binding has not been studied. This study aimed to determine the effect of a point mutation (S47W) of residue 47 of Der p 2 on...

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Detalles Bibliográficos
Autores principales: Kulwanich, Bhakkawarat, Thanyaratsrisakul, Sasipa, Jirapongsananuruk, Orathai, Hales, Belinda J., Thomas, Wayne R., Piboonpocanun, Surapon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267192/
https://www.ncbi.nlm.nih.gov/pubmed/30479083
http://dx.doi.org/10.4168/aair.2019.11.1.129

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