Diphenyl Ethers from a Marine-Derived Aspergillus sydowii

Six new diphenyl ethers (1–6) along with eleven known analogs were isolated from the ethyl acetate extract of a marine-derived Aspergillus sydowii guided by LC-UV-MS. Their structures were unambiguously characterized by HRESIMS, NMR, as well as chemical derivatization. Compounds 1 and 2 are rare dip...

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Detalles Bibliográficos
Autores principales: Wang, Ya-Nan, Mou, Yan-Hua, Dong, Yu, Wu, Yan, Liu, Bing-Yu, Bai, Jian, Yan, Dao-Jiang, Zhang, Le, Feng, Dan-Qing, Pei, Yue-Hu, Hu, You-Cai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267227/
https://www.ncbi.nlm.nih.gov/pubmed/30453472
http://dx.doi.org/10.3390/md16110451
Descripción
Sumario:Six new diphenyl ethers (1–6) along with eleven known analogs were isolated from the ethyl acetate extract of a marine-derived Aspergillus sydowii guided by LC-UV-MS. Their structures were unambiguously characterized by HRESIMS, NMR, as well as chemical derivatization. Compounds 1 and 2 are rare diphenyl ether glycosides containing d-ribose. The absolute configuration of the sugar moieties in compounds 1–3 was determined by a LC-MS method. All the compounds were evaluated for their cytotoxicities against eight cancer cell lines, including 4T1, U937, PC3, HL-60, HT-29, A549, NCI-H460, and K562, and compounds 1, 5, 6, and 8–11 were found to exhibit selective cytotoxicity against different cancer cell lines.

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