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Cytoarchitecture, probability maps, and functions of the human supplementary and pre-supplementary motor areas

The dorsal  mesial frontal cortex contains the supplementary motor area (SMA) and the pre-supplementary motor area (pre-SMA), which play an important role in action and cognition. Evidence from cytoarchitectonic, stimulation, and functional studies suggests structural and functional divergence betwe...

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Autores principales: Ruan, Jianghai, Bludau, Sebastian, Palomero-Gallagher, Nicola, Caspers, Svenja, Mohlberg, Hartmut, Eickhoff, Simon B., Seitz, Rüdiger J., Amunts, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267244/
https://www.ncbi.nlm.nih.gov/pubmed/30187192
http://dx.doi.org/10.1007/s00429-018-1738-6
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author Ruan, Jianghai
Bludau, Sebastian
Palomero-Gallagher, Nicola
Caspers, Svenja
Mohlberg, Hartmut
Eickhoff, Simon B.
Seitz, Rüdiger J.
Amunts, Katrin
author_facet Ruan, Jianghai
Bludau, Sebastian
Palomero-Gallagher, Nicola
Caspers, Svenja
Mohlberg, Hartmut
Eickhoff, Simon B.
Seitz, Rüdiger J.
Amunts, Katrin
author_sort Ruan, Jianghai
collection PubMed
description The dorsal  mesial frontal cortex contains the supplementary motor area (SMA) and the pre-supplementary motor area (pre-SMA), which play an important role in action and cognition. Evidence from cytoarchitectonic, stimulation, and functional studies suggests structural and functional divergence between the two subregions. However, a microstructural map of these areas obtained in a representative sample of brains in a stereotaxic reference space is still lacking. In the present study we show that the dorsal mesial frontal motor cortex comprises two microstructurally different brain regions: area SMA and area pre-SMA. Area-specific cytoarchitectonic patterns were studied in serial histological sections stained for cell bodies of ten human postmortem brains. Borders of the two cortical areas were identified using image analysis and statistical features. The 3D reconstructed areas were transferred to a common reference space, and probabilistic maps were calculated by superimposing the individual maps. A coordinate-based meta-analysis of functional imaging data was subsequently performed using the two probabilistic maps as microstructurally defined seed regions. It revealed that areas SMA and pre-SMA were strongly co-activated with areas in precentral, supramarginal and superior frontal gyri, Rolandic operculum, thalamus, putamen and cerebellum. Both areas were related to motor functions, but area pre-SMA was involved in more complex processes such as learning, cognitive processes and perception. The here described subsequent analyses led to converging evidence supporting the microstructural, and functional segregation of areas SMA and pre-SMA, and maps will be made available to the scientific community to further elucidate the microstructural substrates of motor and cognitive control. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00429-018-1738-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-62672442018-12-11 Cytoarchitecture, probability maps, and functions of the human supplementary and pre-supplementary motor areas Ruan, Jianghai Bludau, Sebastian Palomero-Gallagher, Nicola Caspers, Svenja Mohlberg, Hartmut Eickhoff, Simon B. Seitz, Rüdiger J. Amunts, Katrin Brain Struct Funct Original Article The dorsal  mesial frontal cortex contains the supplementary motor area (SMA) and the pre-supplementary motor area (pre-SMA), which play an important role in action and cognition. Evidence from cytoarchitectonic, stimulation, and functional studies suggests structural and functional divergence between the two subregions. However, a microstructural map of these areas obtained in a representative sample of brains in a stereotaxic reference space is still lacking. In the present study we show that the dorsal mesial frontal motor cortex comprises two microstructurally different brain regions: area SMA and area pre-SMA. Area-specific cytoarchitectonic patterns were studied in serial histological sections stained for cell bodies of ten human postmortem brains. Borders of the two cortical areas were identified using image analysis and statistical features. The 3D reconstructed areas were transferred to a common reference space, and probabilistic maps were calculated by superimposing the individual maps. A coordinate-based meta-analysis of functional imaging data was subsequently performed using the two probabilistic maps as microstructurally defined seed regions. It revealed that areas SMA and pre-SMA were strongly co-activated with areas in precentral, supramarginal and superior frontal gyri, Rolandic operculum, thalamus, putamen and cerebellum. Both areas were related to motor functions, but area pre-SMA was involved in more complex processes such as learning, cognitive processes and perception. The here described subsequent analyses led to converging evidence supporting the microstructural, and functional segregation of areas SMA and pre-SMA, and maps will be made available to the scientific community to further elucidate the microstructural substrates of motor and cognitive control. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00429-018-1738-6) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2018-09-05 2018 /pmc/articles/PMC6267244/ /pubmed/30187192 http://dx.doi.org/10.1007/s00429-018-1738-6 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Ruan, Jianghai
Bludau, Sebastian
Palomero-Gallagher, Nicola
Caspers, Svenja
Mohlberg, Hartmut
Eickhoff, Simon B.
Seitz, Rüdiger J.
Amunts, Katrin
Cytoarchitecture, probability maps, and functions of the human supplementary and pre-supplementary motor areas
title Cytoarchitecture, probability maps, and functions of the human supplementary and pre-supplementary motor areas
title_full Cytoarchitecture, probability maps, and functions of the human supplementary and pre-supplementary motor areas
title_fullStr Cytoarchitecture, probability maps, and functions of the human supplementary and pre-supplementary motor areas
title_full_unstemmed Cytoarchitecture, probability maps, and functions of the human supplementary and pre-supplementary motor areas
title_short Cytoarchitecture, probability maps, and functions of the human supplementary and pre-supplementary motor areas
title_sort cytoarchitecture, probability maps, and functions of the human supplementary and pre-supplementary motor areas
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267244/
https://www.ncbi.nlm.nih.gov/pubmed/30187192
http://dx.doi.org/10.1007/s00429-018-1738-6
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