Anthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete Streptomyces cyaneofuscatus M-169

The potent antimicrobial extract of a culture of the marine derived actinomycete Streptomyces cyaneofuscatus M-169 was fractionated by reversed phase flash chromatography and preparative HPLC to yield the new Gram-positive antibiotic, anthracimycin B (1), together with its congener, anthracimycin (2...

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Autores principales: Rodríguez, Víctor, Martín, Jesús, Sarmiento-Vizcaíno, Aida, de la Cruz, Mercedes, García, Luis A., Blanco, Gloria, Reyes, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267485/
https://www.ncbi.nlm.nih.gov/pubmed/30366404
http://dx.doi.org/10.3390/md16110406
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author Rodríguez, Víctor
Martín, Jesús
Sarmiento-Vizcaíno, Aida
de la Cruz, Mercedes
García, Luis A.
Blanco, Gloria
Reyes, Fernando
author_facet Rodríguez, Víctor
Martín, Jesús
Sarmiento-Vizcaíno, Aida
de la Cruz, Mercedes
García, Luis A.
Blanco, Gloria
Reyes, Fernando
author_sort Rodríguez, Víctor
collection PubMed
description The potent antimicrobial extract of a culture of the marine derived actinomycete Streptomyces cyaneofuscatus M-169 was fractionated by reversed phase flash chromatography and preparative HPLC to yield the new Gram-positive antibiotic, anthracimycin B (1), together with its congener, anthracimycin (2). The structure of the new compound was established by analysis of its ESI-TOF MS and 1D and 2D NMR spectra, and comparison with data published for anthracimycin and anthracimycin BII-2619 (3). Notably, anthracimycin seemed to be the major and almost unique component of the extract detected by HPLC-UV-MS, making our S. cyanofuscatus strain an excellent candidate for further biosynthetic studies of this potent antibiotic.
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spelling pubmed-62674852018-12-06 Anthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete Streptomyces cyaneofuscatus M-169 Rodríguez, Víctor Martín, Jesús Sarmiento-Vizcaíno, Aida de la Cruz, Mercedes García, Luis A. Blanco, Gloria Reyes, Fernando Mar Drugs Article The potent antimicrobial extract of a culture of the marine derived actinomycete Streptomyces cyaneofuscatus M-169 was fractionated by reversed phase flash chromatography and preparative HPLC to yield the new Gram-positive antibiotic, anthracimycin B (1), together with its congener, anthracimycin (2). The structure of the new compound was established by analysis of its ESI-TOF MS and 1D and 2D NMR spectra, and comparison with data published for anthracimycin and anthracimycin BII-2619 (3). Notably, anthracimycin seemed to be the major and almost unique component of the extract detected by HPLC-UV-MS, making our S. cyanofuscatus strain an excellent candidate for further biosynthetic studies of this potent antibiotic. MDPI 2018-10-25 /pmc/articles/PMC6267485/ /pubmed/30366404 http://dx.doi.org/10.3390/md16110406 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rodríguez, Víctor
Martín, Jesús
Sarmiento-Vizcaíno, Aida
de la Cruz, Mercedes
García, Luis A.
Blanco, Gloria
Reyes, Fernando
Anthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete Streptomyces cyaneofuscatus M-169
title Anthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete Streptomyces cyaneofuscatus M-169
title_full Anthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete Streptomyces cyaneofuscatus M-169
title_fullStr Anthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete Streptomyces cyaneofuscatus M-169
title_full_unstemmed Anthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete Streptomyces cyaneofuscatus M-169
title_short Anthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete Streptomyces cyaneofuscatus M-169
title_sort anthracimycin b, a potent antibiotic against gram-positive bacteria isolated from cultures of the deep-sea actinomycete streptomyces cyaneofuscatus m-169
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267485/
https://www.ncbi.nlm.nih.gov/pubmed/30366404
http://dx.doi.org/10.3390/md16110406
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