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Brief report on similar mutational changes in neurofibromatosis type 2 gene in minute pulmonary meningothelial-like nodule and meningioma of the central nervous system

INTRODUCTION: Minute Pulmonary Meningothelial-like Nodules (MPMNs) are usually detected incidentally adjacent to lung cancer tissue. The pathogenesis is unknown. MPMNs reportedly share the status of neurofibromatosis (NF)-2 gene with meningiomas of the central nervous system. RESULTS: Immunohistoche...

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Autores principales: Higuchi, Mitsunori, Watanabe, Masayuki, Inoue, Takuya, Yamaura, Takumi, Suzuki, Tomoko, Saito, Miwako, Niitsuma, Katsunao, Endo, Kotaro, Oshibe, Ikuro, Soeta, Nobutoshi, Saito, Takuro, Hojo, Hiroshi, Munakata, Mitsuru, Suzuki, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267606/
https://www.ncbi.nlm.nih.gov/pubmed/30542514
http://dx.doi.org/10.18632/oncotarget.26325
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author Higuchi, Mitsunori
Watanabe, Masayuki
Inoue, Takuya
Yamaura, Takumi
Suzuki, Tomoko
Saito, Miwako
Niitsuma, Katsunao
Endo, Kotaro
Oshibe, Ikuro
Soeta, Nobutoshi
Saito, Takuro
Hojo, Hiroshi
Munakata, Mitsuru
Suzuki, Hiroyuki
author_facet Higuchi, Mitsunori
Watanabe, Masayuki
Inoue, Takuya
Yamaura, Takumi
Suzuki, Tomoko
Saito, Miwako
Niitsuma, Katsunao
Endo, Kotaro
Oshibe, Ikuro
Soeta, Nobutoshi
Saito, Takuro
Hojo, Hiroshi
Munakata, Mitsuru
Suzuki, Hiroyuki
author_sort Higuchi, Mitsunori
collection PubMed
description INTRODUCTION: Minute Pulmonary Meningothelial-like Nodules (MPMNs) are usually detected incidentally adjacent to lung cancer tissue. The pathogenesis is unknown. MPMNs reportedly share the status of neurofibromatosis (NF)-2 gene with meningiomas of the central nervous system. RESULTS: Immunohistochemical staining of two MPMNs revealed they were positive for epithelial membrane antigen (EMA), vimentin, CD56, and progesterone. We identified deletion of the NF-2 gene in two MPMNs and one CNS meningioma. CONCLUSIONS: MPMN and CNS meningioma may develop via the same mechanism through NF-2 translocation. Further studies are required to elucidate the genetic similarities between these entities. METHODS: We used fluorescence in situ hybridization to explore the status of the NF-2 gene in MPMNs and compare it with that of CNS meningiomas. We used a commercially available locus-specific probe for the NF-2 region to analyze whole tissue sections of two MPMNs and two CNS meningiomas by fluorescence in situ hybridization.
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spelling pubmed-62676062018-12-12 Brief report on similar mutational changes in neurofibromatosis type 2 gene in minute pulmonary meningothelial-like nodule and meningioma of the central nervous system Higuchi, Mitsunori Watanabe, Masayuki Inoue, Takuya Yamaura, Takumi Suzuki, Tomoko Saito, Miwako Niitsuma, Katsunao Endo, Kotaro Oshibe, Ikuro Soeta, Nobutoshi Saito, Takuro Hojo, Hiroshi Munakata, Mitsuru Suzuki, Hiroyuki Oncotarget Research Paper INTRODUCTION: Minute Pulmonary Meningothelial-like Nodules (MPMNs) are usually detected incidentally adjacent to lung cancer tissue. The pathogenesis is unknown. MPMNs reportedly share the status of neurofibromatosis (NF)-2 gene with meningiomas of the central nervous system. RESULTS: Immunohistochemical staining of two MPMNs revealed they were positive for epithelial membrane antigen (EMA), vimentin, CD56, and progesterone. We identified deletion of the NF-2 gene in two MPMNs and one CNS meningioma. CONCLUSIONS: MPMN and CNS meningioma may develop via the same mechanism through NF-2 translocation. Further studies are required to elucidate the genetic similarities between these entities. METHODS: We used fluorescence in situ hybridization to explore the status of the NF-2 gene in MPMNs and compare it with that of CNS meningiomas. We used a commercially available locus-specific probe for the NF-2 region to analyze whole tissue sections of two MPMNs and two CNS meningiomas by fluorescence in situ hybridization. Impact Journals LLC 2018-11-13 /pmc/articles/PMC6267606/ /pubmed/30542514 http://dx.doi.org/10.18632/oncotarget.26325 Text en Copyright: © 2018 Higuchi et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Higuchi, Mitsunori
Watanabe, Masayuki
Inoue, Takuya
Yamaura, Takumi
Suzuki, Tomoko
Saito, Miwako
Niitsuma, Katsunao
Endo, Kotaro
Oshibe, Ikuro
Soeta, Nobutoshi
Saito, Takuro
Hojo, Hiroshi
Munakata, Mitsuru
Suzuki, Hiroyuki
Brief report on similar mutational changes in neurofibromatosis type 2 gene in minute pulmonary meningothelial-like nodule and meningioma of the central nervous system
title Brief report on similar mutational changes in neurofibromatosis type 2 gene in minute pulmonary meningothelial-like nodule and meningioma of the central nervous system
title_full Brief report on similar mutational changes in neurofibromatosis type 2 gene in minute pulmonary meningothelial-like nodule and meningioma of the central nervous system
title_fullStr Brief report on similar mutational changes in neurofibromatosis type 2 gene in minute pulmonary meningothelial-like nodule and meningioma of the central nervous system
title_full_unstemmed Brief report on similar mutational changes in neurofibromatosis type 2 gene in minute pulmonary meningothelial-like nodule and meningioma of the central nervous system
title_short Brief report on similar mutational changes in neurofibromatosis type 2 gene in minute pulmonary meningothelial-like nodule and meningioma of the central nervous system
title_sort brief report on similar mutational changes in neurofibromatosis type 2 gene in minute pulmonary meningothelial-like nodule and meningioma of the central nervous system
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267606/
https://www.ncbi.nlm.nih.gov/pubmed/30542514
http://dx.doi.org/10.18632/oncotarget.26325
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