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Brief report on similar mutational changes in neurofibromatosis type 2 gene in minute pulmonary meningothelial-like nodule and meningioma of the central nervous system
INTRODUCTION: Minute Pulmonary Meningothelial-like Nodules (MPMNs) are usually detected incidentally adjacent to lung cancer tissue. The pathogenesis is unknown. MPMNs reportedly share the status of neurofibromatosis (NF)-2 gene with meningiomas of the central nervous system. RESULTS: Immunohistoche...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Impact Journals LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267606/ https://www.ncbi.nlm.nih.gov/pubmed/30542514 http://dx.doi.org/10.18632/oncotarget.26325 |
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author | Higuchi, Mitsunori Watanabe, Masayuki Inoue, Takuya Yamaura, Takumi Suzuki, Tomoko Saito, Miwako Niitsuma, Katsunao Endo, Kotaro Oshibe, Ikuro Soeta, Nobutoshi Saito, Takuro Hojo, Hiroshi Munakata, Mitsuru Suzuki, Hiroyuki |
author_facet | Higuchi, Mitsunori Watanabe, Masayuki Inoue, Takuya Yamaura, Takumi Suzuki, Tomoko Saito, Miwako Niitsuma, Katsunao Endo, Kotaro Oshibe, Ikuro Soeta, Nobutoshi Saito, Takuro Hojo, Hiroshi Munakata, Mitsuru Suzuki, Hiroyuki |
author_sort | Higuchi, Mitsunori |
collection | PubMed |
description | INTRODUCTION: Minute Pulmonary Meningothelial-like Nodules (MPMNs) are usually detected incidentally adjacent to lung cancer tissue. The pathogenesis is unknown. MPMNs reportedly share the status of neurofibromatosis (NF)-2 gene with meningiomas of the central nervous system. RESULTS: Immunohistochemical staining of two MPMNs revealed they were positive for epithelial membrane antigen (EMA), vimentin, CD56, and progesterone. We identified deletion of the NF-2 gene in two MPMNs and one CNS meningioma. CONCLUSIONS: MPMN and CNS meningioma may develop via the same mechanism through NF-2 translocation. Further studies are required to elucidate the genetic similarities between these entities. METHODS: We used fluorescence in situ hybridization to explore the status of the NF-2 gene in MPMNs and compare it with that of CNS meningiomas. We used a commercially available locus-specific probe for the NF-2 region to analyze whole tissue sections of two MPMNs and two CNS meningiomas by fluorescence in situ hybridization. |
format | Online Article Text |
id | pubmed-6267606 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-62676062018-12-12 Brief report on similar mutational changes in neurofibromatosis type 2 gene in minute pulmonary meningothelial-like nodule and meningioma of the central nervous system Higuchi, Mitsunori Watanabe, Masayuki Inoue, Takuya Yamaura, Takumi Suzuki, Tomoko Saito, Miwako Niitsuma, Katsunao Endo, Kotaro Oshibe, Ikuro Soeta, Nobutoshi Saito, Takuro Hojo, Hiroshi Munakata, Mitsuru Suzuki, Hiroyuki Oncotarget Research Paper INTRODUCTION: Minute Pulmonary Meningothelial-like Nodules (MPMNs) are usually detected incidentally adjacent to lung cancer tissue. The pathogenesis is unknown. MPMNs reportedly share the status of neurofibromatosis (NF)-2 gene with meningiomas of the central nervous system. RESULTS: Immunohistochemical staining of two MPMNs revealed they were positive for epithelial membrane antigen (EMA), vimentin, CD56, and progesterone. We identified deletion of the NF-2 gene in two MPMNs and one CNS meningioma. CONCLUSIONS: MPMN and CNS meningioma may develop via the same mechanism through NF-2 translocation. Further studies are required to elucidate the genetic similarities between these entities. METHODS: We used fluorescence in situ hybridization to explore the status of the NF-2 gene in MPMNs and compare it with that of CNS meningiomas. We used a commercially available locus-specific probe for the NF-2 region to analyze whole tissue sections of two MPMNs and two CNS meningiomas by fluorescence in situ hybridization. Impact Journals LLC 2018-11-13 /pmc/articles/PMC6267606/ /pubmed/30542514 http://dx.doi.org/10.18632/oncotarget.26325 Text en Copyright: © 2018 Higuchi et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Higuchi, Mitsunori Watanabe, Masayuki Inoue, Takuya Yamaura, Takumi Suzuki, Tomoko Saito, Miwako Niitsuma, Katsunao Endo, Kotaro Oshibe, Ikuro Soeta, Nobutoshi Saito, Takuro Hojo, Hiroshi Munakata, Mitsuru Suzuki, Hiroyuki Brief report on similar mutational changes in neurofibromatosis type 2 gene in minute pulmonary meningothelial-like nodule and meningioma of the central nervous system |
title | Brief report on similar mutational changes in neurofibromatosis type 2 gene in minute pulmonary meningothelial-like nodule and meningioma of the central nervous system |
title_full | Brief report on similar mutational changes in neurofibromatosis type 2 gene in minute pulmonary meningothelial-like nodule and meningioma of the central nervous system |
title_fullStr | Brief report on similar mutational changes in neurofibromatosis type 2 gene in minute pulmonary meningothelial-like nodule and meningioma of the central nervous system |
title_full_unstemmed | Brief report on similar mutational changes in neurofibromatosis type 2 gene in minute pulmonary meningothelial-like nodule and meningioma of the central nervous system |
title_short | Brief report on similar mutational changes in neurofibromatosis type 2 gene in minute pulmonary meningothelial-like nodule and meningioma of the central nervous system |
title_sort | brief report on similar mutational changes in neurofibromatosis type 2 gene in minute pulmonary meningothelial-like nodule and meningioma of the central nervous system |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267606/ https://www.ncbi.nlm.nih.gov/pubmed/30542514 http://dx.doi.org/10.18632/oncotarget.26325 |
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