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Association of HLA alleles with autism
BACKGROUND: Autism spectrum disorders (ASD) are a group of heterogeneous neurodevelopmental disorders known by impaired social interaction and activities and abnormal repetitive behavior. As a multifactorial disorder, several genetic and immunological factors have been shown to be implicated in its...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267725/ https://www.ncbi.nlm.nih.gov/pubmed/30568448 http://dx.doi.org/10.2147/NDT.S186673 |
Sumario: | BACKGROUND: Autism spectrum disorders (ASD) are a group of heterogeneous neurodevelopmental disorders known by impaired social interaction and activities and abnormal repetitive behavior. As a multifactorial disorder, several genetic and immunological factors have been shown to be implicated in its pathogenesis. METHODS: Among them are certain human leukocyte antigen (HLA) alleles. In the current study, we genotyped HLA-A, -B & DRB alleles in 103 Iranian ASD patients and 180 age, gender, and ethnic-matched healthy controls. RESULTS: After Boferroni correction no allele or haplotype was associated with genetic susceptibility to ASD in Iranian population. CONCLUSION: Future studies are needed to assess contribution of immunological factors such as HLA alleles in ASD pathogenesis. |
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