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Association of HLA alleles with autism

BACKGROUND: Autism spectrum disorders (ASD) are a group of heterogeneous neurodevelopmental disorders known by impaired social interaction and activities and abnormal repetitive behavior. As a multifactorial disorder, several genetic and immunological factors have been shown to be implicated in its...

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Detalles Bibliográficos
Autores principales: Sayad, Arezou, Akbari, Mohammad Taghi, Noroozi, Rezvan, Omrani, Mir Davood, Inoko, Hidetoshi, Taheri, Mohammad, Ghafouri-Fard, Soudeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267725/
https://www.ncbi.nlm.nih.gov/pubmed/30568448
http://dx.doi.org/10.2147/NDT.S186673
Descripción
Sumario:BACKGROUND: Autism spectrum disorders (ASD) are a group of heterogeneous neurodevelopmental disorders known by impaired social interaction and activities and abnormal repetitive behavior. As a multifactorial disorder, several genetic and immunological factors have been shown to be implicated in its pathogenesis. METHODS: Among them are certain human leukocyte antigen (HLA) alleles. In the current study, we genotyped HLA-A, -B & DRB alleles in 103 Iranian ASD patients and 180 age, gender, and ethnic-matched healthy controls. RESULTS: After Boferroni correction no allele or haplotype was associated with genetic susceptibility to ASD in Iranian population. CONCLUSION: Future studies are needed to assess contribution of immunological factors such as HLA alleles in ASD pathogenesis.