Association of HLA alleles with autism

BACKGROUND: Autism spectrum disorders (ASD) are a group of heterogeneous neurodevelopmental disorders known by impaired social interaction and activities and abnormal repetitive behavior. As a multifactorial disorder, several genetic and immunological factors have been shown to be implicated in its...

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Autores principales: Sayad, Arezou, Akbari, Mohammad Taghi, Noroozi, Rezvan, Omrani, Mir Davood, Inoko, Hidetoshi, Taheri, Mohammad, Ghafouri-Fard, Soudeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267725/
https://www.ncbi.nlm.nih.gov/pubmed/30568448
http://dx.doi.org/10.2147/NDT.S186673
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author Sayad, Arezou
Akbari, Mohammad Taghi
Noroozi, Rezvan
Omrani, Mir Davood
Inoko, Hidetoshi
Taheri, Mohammad
Ghafouri-Fard, Soudeh
author_facet Sayad, Arezou
Akbari, Mohammad Taghi
Noroozi, Rezvan
Omrani, Mir Davood
Inoko, Hidetoshi
Taheri, Mohammad
Ghafouri-Fard, Soudeh
author_sort Sayad, Arezou
collection PubMed
description BACKGROUND: Autism spectrum disorders (ASD) are a group of heterogeneous neurodevelopmental disorders known by impaired social interaction and activities and abnormal repetitive behavior. As a multifactorial disorder, several genetic and immunological factors have been shown to be implicated in its pathogenesis. METHODS: Among them are certain human leukocyte antigen (HLA) alleles. In the current study, we genotyped HLA-A, -B & DRB alleles in 103 Iranian ASD patients and 180 age, gender, and ethnic-matched healthy controls. RESULTS: After Boferroni correction no allele or haplotype was associated with genetic susceptibility to ASD in Iranian population. CONCLUSION: Future studies are needed to assess contribution of immunological factors such as HLA alleles in ASD pathogenesis.
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spelling pubmed-62677252018-12-19 Association of HLA alleles with autism Sayad, Arezou Akbari, Mohammad Taghi Noroozi, Rezvan Omrani, Mir Davood Inoko, Hidetoshi Taheri, Mohammad Ghafouri-Fard, Soudeh Neuropsychiatr Dis Treat Original Research BACKGROUND: Autism spectrum disorders (ASD) are a group of heterogeneous neurodevelopmental disorders known by impaired social interaction and activities and abnormal repetitive behavior. As a multifactorial disorder, several genetic and immunological factors have been shown to be implicated in its pathogenesis. METHODS: Among them are certain human leukocyte antigen (HLA) alleles. In the current study, we genotyped HLA-A, -B & DRB alleles in 103 Iranian ASD patients and 180 age, gender, and ethnic-matched healthy controls. RESULTS: After Boferroni correction no allele or haplotype was associated with genetic susceptibility to ASD in Iranian population. CONCLUSION: Future studies are needed to assess contribution of immunological factors such as HLA alleles in ASD pathogenesis. Dove Medical Press 2018-11-27 /pmc/articles/PMC6267725/ /pubmed/30568448 http://dx.doi.org/10.2147/NDT.S186673 Text en © 2018 Sayad et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Sayad, Arezou
Akbari, Mohammad Taghi
Noroozi, Rezvan
Omrani, Mir Davood
Inoko, Hidetoshi
Taheri, Mohammad
Ghafouri-Fard, Soudeh
Association of HLA alleles with autism
title Association of HLA alleles with autism
title_full Association of HLA alleles with autism
title_fullStr Association of HLA alleles with autism
title_full_unstemmed Association of HLA alleles with autism
title_short Association of HLA alleles with autism
title_sort association of hla alleles with autism
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267725/
https://www.ncbi.nlm.nih.gov/pubmed/30568448
http://dx.doi.org/10.2147/NDT.S186673
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