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Association of soluble TREM-like transcript-1 with clinical features and patient reported outcomes in systemic lupus erythematosus

OBJECTIVE: The soluble triggering receptor expressed on myeloid cells (TREM-1)-like transcript 1 (sTLT-1) has a modulatory effect on the activation of TREM-1. We compared plasma sTLT-1 levels between patients with systemic lupus erythematosus (SLE) and healthy individuals and determined the associat...

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Autores principales: Vázquez-Otero, Ileana, Rodríguez-Navedo, Yerania, Vilá-Rivera, Karina, Nieves-Plaza, Mariely, Morales-Ortiz, Jessica, Washington, A. Valance, Vilá, Luis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical Research and Education Association 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267757/
https://www.ncbi.nlm.nih.gov/pubmed/30308137
http://dx.doi.org/10.5152/eurjrheum.2018.18074
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author Vázquez-Otero, Ileana
Rodríguez-Navedo, Yerania
Vilá-Rivera, Karina
Nieves-Plaza, Mariely
Morales-Ortiz, Jessica
Washington, A. Valance
Vilá, Luis M.
author_facet Vázquez-Otero, Ileana
Rodríguez-Navedo, Yerania
Vilá-Rivera, Karina
Nieves-Plaza, Mariely
Morales-Ortiz, Jessica
Washington, A. Valance
Vilá, Luis M.
author_sort Vázquez-Otero, Ileana
collection PubMed
description OBJECTIVE: The soluble triggering receptor expressed on myeloid cells (TREM-1)-like transcript 1 (sTLT-1) has a modulatory effect on the activation of TREM-1. We compared plasma sTLT-1 levels between patients with systemic lupus erythematosus (SLE) and healthy individuals and determined the association between sTLT-1 levels and clinical features and patient-reported outcomes (PROs) among patients with lupus. METHODS: An unmatched case-control study was conducted in 46 patients with SLE and 28 healthy subjects. sTLT-1 plasma levels were determined using enzyme-linked immunosorbent assay. Demographic factors, SLE manifestations, comorbidities, pharmacologic profile, disease activity (per SLAM-R), damage accrual, and PROs (as per Lupus Patient-Reported Outcome [LupusPRO]) were studied. RESULTS: Patients with SLE were found to have lower sTLT-1 levels compared with healthy individuals (9.0±7.2 vs. 18.6±22.3 pg/mL, p=0.008). Among patients with SLE, higher sTLT-1 levels were found in those taking corticosteroids (11.1±8.8 vs. 6.9±4.6 pg/mL, p=0.014). Significant correlations were found for the cognition (r=−0.442, p=0.027) and desires/goals (r=0.435, p=0.030) domains of LupusPRO. A tendency was observed between sTLT-1 levels and the SLAM-R (r=−0.278, p=0.064) and the lupus symptoms (r=−0.388, p=0.055) and physical health (r=−0.382, p=0.060) domains of LupusPRO. CONCLUSION: Compared with healthy individuals, sTLT-1 levels were significantly lower in patients with SLE. Among patients with SLE, correlations were observed for some domains of LupusPRO. Given that sTLT-1 has anti-inflammatory properties, the deficiency of this protein could play an important role in the pathogenesis of SLE.
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spelling pubmed-62677572018-12-06 Association of soluble TREM-like transcript-1 with clinical features and patient reported outcomes in systemic lupus erythematosus Vázquez-Otero, Ileana Rodríguez-Navedo, Yerania Vilá-Rivera, Karina Nieves-Plaza, Mariely Morales-Ortiz, Jessica Washington, A. Valance Vilá, Luis M. Eur J Rheumatol Original Article OBJECTIVE: The soluble triggering receptor expressed on myeloid cells (TREM-1)-like transcript 1 (sTLT-1) has a modulatory effect on the activation of TREM-1. We compared plasma sTLT-1 levels between patients with systemic lupus erythematosus (SLE) and healthy individuals and determined the association between sTLT-1 levels and clinical features and patient-reported outcomes (PROs) among patients with lupus. METHODS: An unmatched case-control study was conducted in 46 patients with SLE and 28 healthy subjects. sTLT-1 plasma levels were determined using enzyme-linked immunosorbent assay. Demographic factors, SLE manifestations, comorbidities, pharmacologic profile, disease activity (per SLAM-R), damage accrual, and PROs (as per Lupus Patient-Reported Outcome [LupusPRO]) were studied. RESULTS: Patients with SLE were found to have lower sTLT-1 levels compared with healthy individuals (9.0±7.2 vs. 18.6±22.3 pg/mL, p=0.008). Among patients with SLE, higher sTLT-1 levels were found in those taking corticosteroids (11.1±8.8 vs. 6.9±4.6 pg/mL, p=0.014). Significant correlations were found for the cognition (r=−0.442, p=0.027) and desires/goals (r=0.435, p=0.030) domains of LupusPRO. A tendency was observed between sTLT-1 levels and the SLAM-R (r=−0.278, p=0.064) and the lupus symptoms (r=−0.388, p=0.055) and physical health (r=−0.382, p=0.060) domains of LupusPRO. CONCLUSION: Compared with healthy individuals, sTLT-1 levels were significantly lower in patients with SLE. Among patients with SLE, correlations were observed for some domains of LupusPRO. Given that sTLT-1 has anti-inflammatory properties, the deficiency of this protein could play an important role in the pathogenesis of SLE. Medical Research and Education Association 2018-12 2018-10-10 /pmc/articles/PMC6267757/ /pubmed/30308137 http://dx.doi.org/10.5152/eurjrheum.2018.18074 Text en © Copyright by 2018 Medical Research and Education Association http://creativecommons.org/licenses/by-nc/4.0/ Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
spellingShingle Original Article
Vázquez-Otero, Ileana
Rodríguez-Navedo, Yerania
Vilá-Rivera, Karina
Nieves-Plaza, Mariely
Morales-Ortiz, Jessica
Washington, A. Valance
Vilá, Luis M.
Association of soluble TREM-like transcript-1 with clinical features and patient reported outcomes in systemic lupus erythematosus
title Association of soluble TREM-like transcript-1 with clinical features and patient reported outcomes in systemic lupus erythematosus
title_full Association of soluble TREM-like transcript-1 with clinical features and patient reported outcomes in systemic lupus erythematosus
title_fullStr Association of soluble TREM-like transcript-1 with clinical features and patient reported outcomes in systemic lupus erythematosus
title_full_unstemmed Association of soluble TREM-like transcript-1 with clinical features and patient reported outcomes in systemic lupus erythematosus
title_short Association of soluble TREM-like transcript-1 with clinical features and patient reported outcomes in systemic lupus erythematosus
title_sort association of soluble trem-like transcript-1 with clinical features and patient reported outcomes in systemic lupus erythematosus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267757/
https://www.ncbi.nlm.nih.gov/pubmed/30308137
http://dx.doi.org/10.5152/eurjrheum.2018.18074
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