Antinuclear antibody-negative lupus? An ominous presentation of hydralazine-induced lupus syndrome

Up to 10% of systemic lupus erythematosus (SLE) cases are drug-induced; hence, they are called drug-induced lupus syndrome (DILS). Antinuclear antibody (ANA) should be present to diagnose SLE and DILS. ANA-negative lupus is very rare; therefore, it presents a diagnostic challenge. In the medical lit...

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Detalles Bibliográficos
Autores principales: Solomon-Tsegaye, Theodros, Treadwell, Edward L., Obi, Reginald, Pitzalis, Mariavittoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical Research and Education Association 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267758/
https://www.ncbi.nlm.nih.gov/pubmed/30071945
http://dx.doi.org/10.5152/eurjrheum.2018.18040
Descripción
Sumario:Up to 10% of systemic lupus erythematosus (SLE) cases are drug-induced; hence, they are called drug-induced lupus syndrome (DILS). Antinuclear antibody (ANA) should be present to diagnose SLE and DILS. ANA-negative lupus is very rare; therefore, it presents a diagnostic challenge. In the medical literature, two cases of ANA-negative hydralazine-induced lupus syndrome (HILS) have been described within the last year. Here, we present the third such case of HILS with negative ANA serology in a patient who developed considerable pericardial effusion. The association between ANA-negative HILS and pericardial effusion warrants future research.

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