Antinuclear antibody-negative lupus? An ominous presentation of hydralazine-induced lupus syndrome

Up to 10% of systemic lupus erythematosus (SLE) cases are drug-induced; hence, they are called drug-induced lupus syndrome (DILS). Antinuclear antibody (ANA) should be present to diagnose SLE and DILS. ANA-negative lupus is very rare; therefore, it presents a diagnostic challenge. In the medical lit...

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Autores principales: Solomon-Tsegaye, Theodros, Treadwell, Edward L., Obi, Reginald, Pitzalis, Mariavittoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical Research and Education Association 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267758/
https://www.ncbi.nlm.nih.gov/pubmed/30071945
http://dx.doi.org/10.5152/eurjrheum.2018.18040
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author Solomon-Tsegaye, Theodros
Treadwell, Edward L.
Obi, Reginald
Pitzalis, Mariavittoria
author_facet Solomon-Tsegaye, Theodros
Treadwell, Edward L.
Obi, Reginald
Pitzalis, Mariavittoria
author_sort Solomon-Tsegaye, Theodros
collection PubMed
description Up to 10% of systemic lupus erythematosus (SLE) cases are drug-induced; hence, they are called drug-induced lupus syndrome (DILS). Antinuclear antibody (ANA) should be present to diagnose SLE and DILS. ANA-negative lupus is very rare; therefore, it presents a diagnostic challenge. In the medical literature, two cases of ANA-negative hydralazine-induced lupus syndrome (HILS) have been described within the last year. Here, we present the third such case of HILS with negative ANA serology in a patient who developed considerable pericardial effusion. The association between ANA-negative HILS and pericardial effusion warrants future research.
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spelling pubmed-62677582018-12-06 Antinuclear antibody-negative lupus? An ominous presentation of hydralazine-induced lupus syndrome Solomon-Tsegaye, Theodros Treadwell, Edward L. Obi, Reginald Pitzalis, Mariavittoria Eur J Rheumatol Case Report Up to 10% of systemic lupus erythematosus (SLE) cases are drug-induced; hence, they are called drug-induced lupus syndrome (DILS). Antinuclear antibody (ANA) should be present to diagnose SLE and DILS. ANA-negative lupus is very rare; therefore, it presents a diagnostic challenge. In the medical literature, two cases of ANA-negative hydralazine-induced lupus syndrome (HILS) have been described within the last year. Here, we present the third such case of HILS with negative ANA serology in a patient who developed considerable pericardial effusion. The association between ANA-negative HILS and pericardial effusion warrants future research. Medical Research and Education Association 2018-12 2018-06-20 /pmc/articles/PMC6267758/ /pubmed/30071945 http://dx.doi.org/10.5152/eurjrheum.2018.18040 Text en © Copyright by 2018 Medical Research and Education Association http://creativecommons.org/licenses/by-nc/4.0/ Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
spellingShingle Case Report
Solomon-Tsegaye, Theodros
Treadwell, Edward L.
Obi, Reginald
Pitzalis, Mariavittoria
Antinuclear antibody-negative lupus? An ominous presentation of hydralazine-induced lupus syndrome
title Antinuclear antibody-negative lupus? An ominous presentation of hydralazine-induced lupus syndrome
title_full Antinuclear antibody-negative lupus? An ominous presentation of hydralazine-induced lupus syndrome
title_fullStr Antinuclear antibody-negative lupus? An ominous presentation of hydralazine-induced lupus syndrome
title_full_unstemmed Antinuclear antibody-negative lupus? An ominous presentation of hydralazine-induced lupus syndrome
title_short Antinuclear antibody-negative lupus? An ominous presentation of hydralazine-induced lupus syndrome
title_sort antinuclear antibody-negative lupus? an ominous presentation of hydralazine-induced lupus syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267758/
https://www.ncbi.nlm.nih.gov/pubmed/30071945
http://dx.doi.org/10.5152/eurjrheum.2018.18040
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AT obireginald antinuclearantibodynegativelupusanominouspresentationofhydralazineinducedlupussyndrome
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