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Protein targets of thiazolidinone derivatives in Toxoplasma gondii and insights into their binding to ROP18
BACKGROUND: Thiazolidinone derivatives show inhibitory activity (IC(50)) against the Toxoplasma gondii parasite, as well as high selectivity with high therapeutic index. To disclose the target proteins of the thiazolidinone core in this parasite, we explored in silico the active sites of different T...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267824/ https://www.ncbi.nlm.nih.gov/pubmed/30497375 http://dx.doi.org/10.1186/s12864-018-5223-7 |