MMP-9 inhibition promotes anti-tumor immunity through disruption of biochemical and physical barriers to T-cell trafficking to tumors

Matrix metalloproteinase-9 (MMP-9), whose expression is frequently dysregulated in cancer, promotes tumor growth, invasion, and metastasis by multiple mechanisms, including extracellular matrix remodeling and growth-factor and cytokine activation. We developed a monoclonal antibody against murine MM...

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Detalles Bibliográficos
Autores principales: Juric, Vladi, O'Sullivan, Chris, Stefanutti, Erin, Kovalenko, Maria, Greenstein, Andrew, Barry-Hamilton, Vivian, Mikaelian, Igor, Degenhardt, Jeremiah, Yue, Peng, Smith, Victoria, Mikels-Vigdal, Amanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267998/
https://www.ncbi.nlm.nih.gov/pubmed/30500835
http://dx.doi.org/10.1371/journal.pone.0207255

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