Cargando…

Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus

Recent genome-wide association studies (GWAS) have identified multiple new loci which appear to alter coronary artery disease (CAD) risk via arterial wall-specific mechanisms. One of the annotated genes encodes LMOD1 (Leiomodin 1), a member of the actin filament nucleator family that is highly enric...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nanda, Vivek, Wang, Ting, Pjanic, Milos, Liu, Boxiang, Nguyen, Trieu, Matic, Ljubica Perisic, Hedin, Ulf, Koplev, Simon, Ma, Lijiang, Franzén, Oscar, Ruusalepp, Arno, Schadt, Eric E., Björkegren, Johan L. M., Montgomery, Stephen B., Snyder, Michael P., Quertermous, Thomas, Leeper, Nicholas J., Miller, Clint L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268002/ https://www.ncbi.nlm.nih.gov/pubmed/30444878 http://dx.doi.org/10.1371/journal.pgen.1007755

Ejemplares similares

TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells
por: Kim, Juyong Brian, et al.
Publicado: (2017)

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
por: Miller, Clint L., et al.
Publicado: (2016)

Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk
por: Iyer, Dharini, et al.
Publicado: (2018)

CD47 blocking antibodies restore phagocytosis and prevent atherosclerosis
por: Kojima, Yoko, et al.
Publicado: (2016)

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap
por: Nurnberg, Sylvia T., et al.
Publicado: (2015)

LMOD3: the “missing link” in nemaline myopathy?
por: Sandaradura, Sarah A., et al.
Publicado: (2015)

Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal looping
por: Zhao, Quanyi, et al.
Publicado: (2020)

TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression
por: Zhao, Quanyi, et al.
Publicado: (2019)

The HDAC9-associated risk locus promotes coronary artery disease by governing TWIST1
por: Ma, Lijiang, et al.
Publicado: (2022)

Coronary Heart Disease-Associated Variation in TCF21 Disrupts a miR-224 Binding Site and miRNA-Mediated Regulation
por: Miller, Clint L., et al.
Publicado: (2014)

Lmod2piggyBac mutant mice exhibit dilated cardiomyopathy
por: Li, Shuang, et al.
Publicado: (2016)

Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis
por: Wirka, Robert C., et al.
Publicado: (2019)

Genomic profiling of human vascular cells identifies TWIST1 as a causal gene for common vascular diseases
por: Nurnberg, Sylvia T., et al.
Publicado: (2020)

Nebulin and Lmod2 are critical for specifying thin-filament length in skeletal muscle
por: Kiss, Balázs, et al.
Publicado: (2020)

Detailed Functional Characterization of a Waist-Hip Ratio Locus in 7p15.2 Defines an Enhancer Controlling Adipocyte Differentiation
por: Castillejo-Lopez, Casimiro, et al.
Publicado: (2019)

Global analysis of A-to-I RNA editing reveals association with common disease variants
por: Franzén, Oscar, et al.
Publicado: (2018)

Molecular mechanisms of coronary artery disease risk at the PDGFD locus
por: Kim, Hyun-Jung, et al.
Publicado: (2023)

Molecular mechanisms of coronary artery disease risk at the PDGFD locus
por: Kim, Hyun-Jung, et al.
Publicado: (2023)

Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap
por: Nurnberg, S.T., et al.
Publicado: (2015)

Compound Heterozygosity for Novel Truncating Variants in the LMOD3 Gene as the Cause of Polyhydramnios in Two Successive Fetuses
por: Wang, Ye, et al.
Publicado: (2019)

Neonatal-lethal dilated cardiomyopathy due to a homozygous LMOD2 donor splice-site variant
por: Yuen, Michaela, et al.
Publicado: (2022)

Disease-Related Growth Factor and Embryonic Signaling Pathways Modulate an Enhancer of TCF21 Expression at the 6q23.2 Coronary Heart Disease Locus
por: Miller, Clint L., et al.
Publicado: (2013)

Nexilin/NEXN controls actin polymerization in smooth muscle and is regulated by myocardin family coactivators and YAP
por: Zhu, Baoyi, et al.
Publicado: (2018)

Whole-Exome Sequencing Identifies Homozygote Nonsense Variants in LMOD2 Gene Causing Infantile Dilated Cardiomyopathy
por: Sono, Reiri, et al.
Publicado: (2023)

PECAM1, COL4A2, PHACTR1, and LMOD1 Gene Polymorphisms in Patients with Unstable Angina
por: Kosiński, Krzysztof, et al.
Publicado: (2022)

Early Death of 2 Siblings Related to Mutations in LMOD2, a Recently Discovered Cause of Neonatal Dilated Cardiomyopathy
por: Greenway, Steven C., et al.
Publicado: (2021)

EnsembleCNV: an ensemble machine learning algorithm to identify and genotype copy number variation using SNP array data
por: Zhang, Zhongyang, et al.
Publicado: (2019)

Biomechanical Assessment of Macro-Calcification in Human Carotid Atherosclerosis and Its Impact on Smooth Muscle Cell Phenotype
por: Seime, Till, et al.
Publicado: (2022)

Disruption of cardiac thin filament assembly arising from a mutation in LMOD2: A novel mechanism of neonatal dilated cardiomyopathy
por: Ahrens-Nicklas, Rebecca C., et al.
Publicado: (2019)

LMOD1, an oncogene associated with Lauren classification, regulates the metastasis of gastric cancer cells through the FAK-AKT/mTOR pathway
por: Tan, Yuen, et al.
Publicado: (2022)

Altered metabolism distinguishes high-risk from stable carotid atherosclerotic plaques
por: Tomas, Lukas, et al.
Publicado: (2018)

Transient receptor potential cation channel subfamily C member 6 participates in functional regulation of vascular smooth muscle cells
por: Matic, Ljubica
Publicado: (2020)

The role of polycarbonate monomer bisphenol-A in insulin resistance
por: Pjanic, Milos
Publicado: (2017)

An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease
por: Cohain, Ariella T., et al.
Publicado: (2021)

Shared and distinct pathways and networks genetically linked to coronary artery disease between human and mouse
por: Kurt, Zeyneb, et al.
Publicado: (2023)

Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease
por: Talukdar, Husain A., et al.
Publicado: (2016)

Transcriptomic profiling of experimental arterial injury reveals new mechanisms and temporal dynamics in vascular healing response
por: Röhl, Samuel, et al.
Publicado: (2020)

Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci
por: Sazonova, Olga, et al.
Publicado: (2015)

CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation
por: Cook, Naomi L., et al.
Publicado: (2019)

Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes
por: Li, Ling, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_95t7bd5cjvv1n6dmdq0ktkl39f