Side-chain Modifications of Highly Functionalized 3(2H)-Furanones

A series of 3(2H)-furanones, based on side-chain modifications of a parent 3(2H)-furanone, was synthesized in good yield. The parent compound was prepared by hydrogenolysis, and subsequent acid hydrolysis, of isoxazole derivatives. The isoxazole was prepared by a [3+2] 1,3-dipolar cycloaddition reac...

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Autores principales: Nardini, Viviani, Rodrigues, Shirley Muniz Machado, Constantino, Maurício Gomes, da Silva, Gil Valdo José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268025/
https://www.ncbi.nlm.nih.gov/pubmed/23085662
http://dx.doi.org/10.3390/molecules171012151
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author Nardini, Viviani
Rodrigues, Shirley Muniz Machado
Constantino, Maurício Gomes
da Silva, Gil Valdo José
author_facet Nardini, Viviani
Rodrigues, Shirley Muniz Machado
Constantino, Maurício Gomes
da Silva, Gil Valdo José
author_sort Nardini, Viviani
collection PubMed
description A series of 3(2H)-furanones, based on side-chain modifications of a parent 3(2H)-furanone, was synthesized in good yield. The parent compound was prepared by hydrogenolysis, and subsequent acid hydrolysis, of isoxazole derivatives. The isoxazole was prepared by a [3+2] 1,3-dipolar cycloaddition reaction between 3-butyn-2-ol and nitrile oxide.
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spelling pubmed-62680252018-12-12 Side-chain Modifications of Highly Functionalized 3(2H)-Furanones Nardini, Viviani Rodrigues, Shirley Muniz Machado Constantino, Maurício Gomes da Silva, Gil Valdo José Molecules Article A series of 3(2H)-furanones, based on side-chain modifications of a parent 3(2H)-furanone, was synthesized in good yield. The parent compound was prepared by hydrogenolysis, and subsequent acid hydrolysis, of isoxazole derivatives. The isoxazole was prepared by a [3+2] 1,3-dipolar cycloaddition reaction between 3-butyn-2-ol and nitrile oxide. MDPI 2012-10-16 /pmc/articles/PMC6268025/ /pubmed/23085662 http://dx.doi.org/10.3390/molecules171012151 Text en © 2012 by the authors. licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Nardini, Viviani
Rodrigues, Shirley Muniz Machado
Constantino, Maurício Gomes
da Silva, Gil Valdo José
Side-chain Modifications of Highly Functionalized 3(2H)-Furanones
title Side-chain Modifications of Highly Functionalized 3(2H)-Furanones
title_full Side-chain Modifications of Highly Functionalized 3(2H)-Furanones
title_fullStr Side-chain Modifications of Highly Functionalized 3(2H)-Furanones
title_full_unstemmed Side-chain Modifications of Highly Functionalized 3(2H)-Furanones
title_short Side-chain Modifications of Highly Functionalized 3(2H)-Furanones
title_sort side-chain modifications of highly functionalized 3(2h)-furanones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268025/
https://www.ncbi.nlm.nih.gov/pubmed/23085662
http://dx.doi.org/10.3390/molecules171012151
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