Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] Derivatives

A series of 3'-aminospiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine]-2,5',10'-trione derivatives have been synthesized by a one-pot three-component reaction of isatin, malononitrile or ethyl cyanoacetate and phthalhydrazide catalyzed by piperidine under ultrasound irradiation. For...

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Detalles Bibliográficos
Autores principales: Wang, Juxian, Bai, Xiaoguang, Xu, Changliang, Wang, Yucheng, Lin, Wei, Zou, Yi, Shi, Daqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268026/
https://www.ncbi.nlm.nih.gov/pubmed/22825620
http://dx.doi.org/10.3390/molecules17078674
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author Wang, Juxian
Bai, Xiaoguang
Xu, Changliang
Wang, Yucheng
Lin, Wei
Zou, Yi
Shi, Daqing
author_facet Wang, Juxian
Bai, Xiaoguang
Xu, Changliang
Wang, Yucheng
Lin, Wei
Zou, Yi
Shi, Daqing
author_sort Wang, Juxian
collection PubMed
description A series of 3'-aminospiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine]-2,5',10'-trione derivatives have been synthesized by a one-pot three-component reaction of isatin, malononitrile or ethyl cyanoacetate and phthalhydrazide catalyzed by piperidine under ultrasound irradiation. For comparison the reactions were carried out under both conventional and ultrasonic conditions. In general, improvement in rates and yields were observed when the reactions were carried out under sonication compared with classical conditions.
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spelling pubmed-62680262018-12-12 Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] Derivatives Wang, Juxian Bai, Xiaoguang Xu, Changliang Wang, Yucheng Lin, Wei Zou, Yi Shi, Daqing Molecules Article A series of 3'-aminospiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine]-2,5',10'-trione derivatives have been synthesized by a one-pot three-component reaction of isatin, malononitrile or ethyl cyanoacetate and phthalhydrazide catalyzed by piperidine under ultrasound irradiation. For comparison the reactions were carried out under both conventional and ultrasonic conditions. In general, improvement in rates and yields were observed when the reactions were carried out under sonication compared with classical conditions. MDPI 2012-07-23 /pmc/articles/PMC6268026/ /pubmed/22825620 http://dx.doi.org/10.3390/molecules17078674 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wang, Juxian
Bai, Xiaoguang
Xu, Changliang
Wang, Yucheng
Lin, Wei
Zou, Yi
Shi, Daqing
Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] Derivatives
title Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] Derivatives
title_full Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] Derivatives
title_fullStr Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] Derivatives
title_full_unstemmed Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] Derivatives
title_short Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] Derivatives
title_sort ultrasound-promoted one-pot, three-component synthesis of spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268026/
https://www.ncbi.nlm.nih.gov/pubmed/22825620
http://dx.doi.org/10.3390/molecules17078674
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