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DNA as a Chiral Scaffold for Asymmetric Synthesi

The application of DNA-based hybrid catalysts for enantioselective synthesis has recently emerged. These catalysts, self-assembled from DNA and a metal complex with a specific ligand through supramolecular or covalent anchoring strategies, have demonstrated high enantioselectivity in a variety of ca...

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Detalles Bibliográficos
Autores principales: Park, Soyoung, Sugiyama, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268040/
https://www.ncbi.nlm.nih.gov/pubmed/23114615
http://dx.doi.org/10.3390/molecules171112792
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author Park, Soyoung
Sugiyama, Hiroshi
author_facet Park, Soyoung
Sugiyama, Hiroshi
author_sort Park, Soyoung
collection PubMed
description The application of DNA-based hybrid catalysts for enantioselective synthesis has recently emerged. These catalysts, self-assembled from DNA and a metal complex with a specific ligand through supramolecular or covalent anchoring strategies, have demonstrated high enantioselectivity in a variety of carbon-carbon or carbon-heteroatom bond-forming reactions and have expanded their role in asymmetric catalysis. In this review, we summarize the advent and significant progress of DNA-based asymmetric catalysis and discuss remaining challenges in using DNA as a chiral scaffold. We hope that this review will inspire many of today’s active scientists in asymmetric catalysis.
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spelling pubmed-62680402018-12-13 DNA as a Chiral Scaffold for Asymmetric Synthesi Park, Soyoung Sugiyama, Hiroshi Molecules Review The application of DNA-based hybrid catalysts for enantioselective synthesis has recently emerged. These catalysts, self-assembled from DNA and a metal complex with a specific ligand through supramolecular or covalent anchoring strategies, have demonstrated high enantioselectivity in a variety of carbon-carbon or carbon-heteroatom bond-forming reactions and have expanded their role in asymmetric catalysis. In this review, we summarize the advent and significant progress of DNA-based asymmetric catalysis and discuss remaining challenges in using DNA as a chiral scaffold. We hope that this review will inspire many of today’s active scientists in asymmetric catalysis. MDPI 2012-10-31 /pmc/articles/PMC6268040/ /pubmed/23114615 http://dx.doi.org/10.3390/molecules171112792 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Park, Soyoung
Sugiyama, Hiroshi
DNA as a Chiral Scaffold for Asymmetric Synthesi
title DNA as a Chiral Scaffold for Asymmetric Synthesi
title_full DNA as a Chiral Scaffold for Asymmetric Synthesi
title_fullStr DNA as a Chiral Scaffold for Asymmetric Synthesi
title_full_unstemmed DNA as a Chiral Scaffold for Asymmetric Synthesi
title_short DNA as a Chiral Scaffold for Asymmetric Synthesi
title_sort dna as a chiral scaffold for asymmetric synthesi
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268040/
https://www.ncbi.nlm.nih.gov/pubmed/23114615
http://dx.doi.org/10.3390/molecules171112792
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