Cargando…
DNA as a Chiral Scaffold for Asymmetric Synthesi
The application of DNA-based hybrid catalysts for enantioselective synthesis has recently emerged. These catalysts, self-assembled from DNA and a metal complex with a specific ligand through supramolecular or covalent anchoring strategies, have demonstrated high enantioselectivity in a variety of ca...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268040/ https://www.ncbi.nlm.nih.gov/pubmed/23114615 http://dx.doi.org/10.3390/molecules171112792 |
_version_ | 1783376198938656768 |
---|---|
author | Park, Soyoung Sugiyama, Hiroshi |
author_facet | Park, Soyoung Sugiyama, Hiroshi |
author_sort | Park, Soyoung |
collection | PubMed |
description | The application of DNA-based hybrid catalysts for enantioselective synthesis has recently emerged. These catalysts, self-assembled from DNA and a metal complex with a specific ligand through supramolecular or covalent anchoring strategies, have demonstrated high enantioselectivity in a variety of carbon-carbon or carbon-heteroatom bond-forming reactions and have expanded their role in asymmetric catalysis. In this review, we summarize the advent and significant progress of DNA-based asymmetric catalysis and discuss remaining challenges in using DNA as a chiral scaffold. We hope that this review will inspire many of today’s active scientists in asymmetric catalysis. |
format | Online Article Text |
id | pubmed-6268040 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62680402018-12-13 DNA as a Chiral Scaffold for Asymmetric Synthesi Park, Soyoung Sugiyama, Hiroshi Molecules Review The application of DNA-based hybrid catalysts for enantioselective synthesis has recently emerged. These catalysts, self-assembled from DNA and a metal complex with a specific ligand through supramolecular or covalent anchoring strategies, have demonstrated high enantioselectivity in a variety of carbon-carbon or carbon-heteroatom bond-forming reactions and have expanded their role in asymmetric catalysis. In this review, we summarize the advent and significant progress of DNA-based asymmetric catalysis and discuss remaining challenges in using DNA as a chiral scaffold. We hope that this review will inspire many of today’s active scientists in asymmetric catalysis. MDPI 2012-10-31 /pmc/articles/PMC6268040/ /pubmed/23114615 http://dx.doi.org/10.3390/molecules171112792 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Park, Soyoung Sugiyama, Hiroshi DNA as a Chiral Scaffold for Asymmetric Synthesi |
title | DNA as a Chiral Scaffold for Asymmetric Synthesi |
title_full | DNA as a Chiral Scaffold for Asymmetric Synthesi |
title_fullStr | DNA as a Chiral Scaffold for Asymmetric Synthesi |
title_full_unstemmed | DNA as a Chiral Scaffold for Asymmetric Synthesi |
title_short | DNA as a Chiral Scaffold for Asymmetric Synthesi |
title_sort | dna as a chiral scaffold for asymmetric synthesi |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268040/ https://www.ncbi.nlm.nih.gov/pubmed/23114615 http://dx.doi.org/10.3390/molecules171112792 |
work_keys_str_mv | AT parksoyoung dnaasachiralscaffoldforasymmetricsynthesi AT sugiyamahiroshi dnaasachiralscaffoldforasymmetricsynthesi |