Cargando…

Ultrasound-Promoted Greener Synthesis of Novel Trifurcate 3-Substituted-chroman-2,4-dione Derivatives and Their Drug-Likeness Evaluation

An efficient and convenient approach for one-pot synthesis of 3-substituted chroman-2,4-diones via a three-component reaction of aromatic aldehydes, 4-hydroxy- coumarins and diverse pyrazolone derivatives was described. The combinatorial synthesis for this methodology was achieved by applying ultras...

Descripción completa

Detalles Bibliográficos
Autores principales: Liang, Chengyuan, Jiang, Hailong, Zhou, Zhiguang, Lei, Dong, Xue, Yu, Yao, Qizheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268048/
https://www.ncbi.nlm.nih.gov/pubmed/23192190
http://dx.doi.org/10.3390/molecules171214146
_version_ 1783376200782053376
author Liang, Chengyuan
Jiang, Hailong
Zhou, Zhiguang
Lei, Dong
Xue, Yu
Yao, Qizheng
author_facet Liang, Chengyuan
Jiang, Hailong
Zhou, Zhiguang
Lei, Dong
Xue, Yu
Yao, Qizheng
author_sort Liang, Chengyuan
collection PubMed
description An efficient and convenient approach for one-pot synthesis of 3-substituted chroman-2,4-diones via a three-component reaction of aromatic aldehydes, 4-hydroxy- coumarins and diverse pyrazolone derivatives was described. The combinatorial synthesis for this methodology was achieved by applying ultrasound irradiation in the absence of activator while making use of water as green solvent. Additionally, novel chroman-2,4-dione derivatives attached to an edaravone moiety represent an exploitable source of brand new anticancer agents. In comparison with conventional methods, experimental simplicity, good functional group tolerance, excellent yields, short routine, and atom efficiency are prominent features of this sonocatalyzed procedure.
format Online
Article
Text
id pubmed-6268048
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62680482018-12-14 Ultrasound-Promoted Greener Synthesis of Novel Trifurcate 3-Substituted-chroman-2,4-dione Derivatives and Their Drug-Likeness Evaluation Liang, Chengyuan Jiang, Hailong Zhou, Zhiguang Lei, Dong Xue, Yu Yao, Qizheng Molecules Article An efficient and convenient approach for one-pot synthesis of 3-substituted chroman-2,4-diones via a three-component reaction of aromatic aldehydes, 4-hydroxy- coumarins and diverse pyrazolone derivatives was described. The combinatorial synthesis for this methodology was achieved by applying ultrasound irradiation in the absence of activator while making use of water as green solvent. Additionally, novel chroman-2,4-dione derivatives attached to an edaravone moiety represent an exploitable source of brand new anticancer agents. In comparison with conventional methods, experimental simplicity, good functional group tolerance, excellent yields, short routine, and atom efficiency are prominent features of this sonocatalyzed procedure. MDPI 2012-11-28 /pmc/articles/PMC6268048/ /pubmed/23192190 http://dx.doi.org/10.3390/molecules171214146 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Liang, Chengyuan
Jiang, Hailong
Zhou, Zhiguang
Lei, Dong
Xue, Yu
Yao, Qizheng
Ultrasound-Promoted Greener Synthesis of Novel Trifurcate 3-Substituted-chroman-2,4-dione Derivatives and Their Drug-Likeness Evaluation
title Ultrasound-Promoted Greener Synthesis of Novel Trifurcate 3-Substituted-chroman-2,4-dione Derivatives and Their Drug-Likeness Evaluation
title_full Ultrasound-Promoted Greener Synthesis of Novel Trifurcate 3-Substituted-chroman-2,4-dione Derivatives and Their Drug-Likeness Evaluation
title_fullStr Ultrasound-Promoted Greener Synthesis of Novel Trifurcate 3-Substituted-chroman-2,4-dione Derivatives and Their Drug-Likeness Evaluation
title_full_unstemmed Ultrasound-Promoted Greener Synthesis of Novel Trifurcate 3-Substituted-chroman-2,4-dione Derivatives and Their Drug-Likeness Evaluation
title_short Ultrasound-Promoted Greener Synthesis of Novel Trifurcate 3-Substituted-chroman-2,4-dione Derivatives and Their Drug-Likeness Evaluation
title_sort ultrasound-promoted greener synthesis of novel trifurcate 3-substituted-chroman-2,4-dione derivatives and their drug-likeness evaluation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268048/
https://www.ncbi.nlm.nih.gov/pubmed/23192190
http://dx.doi.org/10.3390/molecules171214146
work_keys_str_mv AT liangchengyuan ultrasoundpromotedgreenersynthesisofnoveltrifurcate3substitutedchroman24dionederivativesandtheirdruglikenessevaluation
AT jianghailong ultrasoundpromotedgreenersynthesisofnoveltrifurcate3substitutedchroman24dionederivativesandtheirdruglikenessevaluation
AT zhouzhiguang ultrasoundpromotedgreenersynthesisofnoveltrifurcate3substitutedchroman24dionederivativesandtheirdruglikenessevaluation
AT leidong ultrasoundpromotedgreenersynthesisofnoveltrifurcate3substitutedchroman24dionederivativesandtheirdruglikenessevaluation
AT xueyu ultrasoundpromotedgreenersynthesisofnoveltrifurcate3substitutedchroman24dionederivativesandtheirdruglikenessevaluation
AT yaoqizheng ultrasoundpromotedgreenersynthesisofnoveltrifurcate3substitutedchroman24dionederivativesandtheirdruglikenessevaluation