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Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata

Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β,7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5β,8α,9β,10α,...

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Autores principales: Yu, Chia-Chun, Hsieh, Ching-Ruey, Hsiao, George, Chen, Pi-Yu, Chang, Meng-Lun, Yin, Hwa-Wen, Lee, Tzong-Huei, Lee, Ching-Kuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268049/
https://www.ncbi.nlm.nih.gov/pubmed/22354186
http://dx.doi.org/10.3390/molecules17022082
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author Yu, Chia-Chun
Hsieh, Ching-Ruey
Hsiao, George
Chen, Pi-Yu
Chang, Meng-Lun
Yin, Hwa-Wen
Lee, Tzong-Huei
Lee, Ching-Kuo
author_facet Yu, Chia-Chun
Hsieh, Ching-Ruey
Hsiao, George
Chen, Pi-Yu
Chang, Meng-Lun
Yin, Hwa-Wen
Lee, Tzong-Huei
Lee, Ching-Kuo
author_sort Yu, Chia-Chun
collection PubMed
description Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β,7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5β,8α,9β,10α,12α)-12-hydroxyatis-16-ene-3,14-dione (6). The structures of compounds 1−6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3−5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.
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spelling pubmed-62680492018-12-10 Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata Yu, Chia-Chun Hsieh, Ching-Ruey Hsiao, George Chen, Pi-Yu Chang, Meng-Lun Yin, Hwa-Wen Lee, Tzong-Huei Lee, Ching-Kuo Molecules Article Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β,7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5β,8α,9β,10α,12α)-12-hydroxyatis-16-ene-3,14-dione (6). The structures of compounds 1−6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3−5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080. MDPI 2012-02-21 /pmc/articles/PMC6268049/ /pubmed/22354186 http://dx.doi.org/10.3390/molecules17022082 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yu, Chia-Chun
Hsieh, Ching-Ruey
Hsiao, George
Chen, Pi-Yu
Chang, Meng-Lun
Yin, Hwa-Wen
Lee, Tzong-Huei
Lee, Ching-Kuo
Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata
title Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata
title_full Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata
title_fullStr Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata
title_full_unstemmed Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata
title_short Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata
title_sort regulated expressions of mmp-2, -9 by diterpenoids from euphorbia formosana hayata
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268049/
https://www.ncbi.nlm.nih.gov/pubmed/22354186
http://dx.doi.org/10.3390/molecules17022082
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