Cargando…
Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata
Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β,7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5β,8α,9β,10α,...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268049/ https://www.ncbi.nlm.nih.gov/pubmed/22354186 http://dx.doi.org/10.3390/molecules17022082 |
_version_ | 1783376201013788672 |
---|---|
author | Yu, Chia-Chun Hsieh, Ching-Ruey Hsiao, George Chen, Pi-Yu Chang, Meng-Lun Yin, Hwa-Wen Lee, Tzong-Huei Lee, Ching-Kuo |
author_facet | Yu, Chia-Chun Hsieh, Ching-Ruey Hsiao, George Chen, Pi-Yu Chang, Meng-Lun Yin, Hwa-Wen Lee, Tzong-Huei Lee, Ching-Kuo |
author_sort | Yu, Chia-Chun |
collection | PubMed |
description | Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β,7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5β,8α,9β,10α,12α)-12-hydroxyatis-16-ene-3,14-dione (6). The structures of compounds 1−6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3−5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080. |
format | Online Article Text |
id | pubmed-6268049 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62680492018-12-10 Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata Yu, Chia-Chun Hsieh, Ching-Ruey Hsiao, George Chen, Pi-Yu Chang, Meng-Lun Yin, Hwa-Wen Lee, Tzong-Huei Lee, Ching-Kuo Molecules Article Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3β,7β-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5β,8α,9β,10α,12α)-12-hydroxyatis-16-ene-3,14-dione (6). The structures of compounds 1−6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3−5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080. MDPI 2012-02-21 /pmc/articles/PMC6268049/ /pubmed/22354186 http://dx.doi.org/10.3390/molecules17022082 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Yu, Chia-Chun Hsieh, Ching-Ruey Hsiao, George Chen, Pi-Yu Chang, Meng-Lun Yin, Hwa-Wen Lee, Tzong-Huei Lee, Ching-Kuo Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata |
title | Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata |
title_full | Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata |
title_fullStr | Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata |
title_full_unstemmed | Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata |
title_short | Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata |
title_sort | regulated expressions of mmp-2, -9 by diterpenoids from euphorbia formosana hayata |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268049/ https://www.ncbi.nlm.nih.gov/pubmed/22354186 http://dx.doi.org/10.3390/molecules17022082 |
work_keys_str_mv | AT yuchiachun regulatedexpressionsofmmp29byditerpenoidsfromeuphorbiaformosanahayata AT hsiehchingruey regulatedexpressionsofmmp29byditerpenoidsfromeuphorbiaformosanahayata AT hsiaogeorge regulatedexpressionsofmmp29byditerpenoidsfromeuphorbiaformosanahayata AT chenpiyu regulatedexpressionsofmmp29byditerpenoidsfromeuphorbiaformosanahayata AT changmenglun regulatedexpressionsofmmp29byditerpenoidsfromeuphorbiaformosanahayata AT yinhwawen regulatedexpressionsofmmp29byditerpenoidsfromeuphorbiaformosanahayata AT leetzonghuei regulatedexpressionsofmmp29byditerpenoidsfromeuphorbiaformosanahayata AT leechingkuo regulatedexpressionsofmmp29byditerpenoidsfromeuphorbiaformosanahayata |