Two Novel Naphthalene Glucosides and an Anthraquinone Isolated from Rumex dentatus and Their Antiproliferation Activities in Four Cell Lines

An ethyl acetate extract of the roots of Rumex dentatus L. was investigated. Three compounds were identified by their spectroscopic data as chrysophanol (1), 6-methyl-7-acetyl-1, 8-dihydroxy-3-methoxy naphthalene-1-O-β-D(L)-glucoside (2) and 6-methyl-7-acetyl-1, 8-dihydroxy naphthalene-1-O-β-D(L)-gl...

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Autores principales: Zhang, Hui, Guo, Zengjun, Wu, Nan, Xu, Wenming, Han, Ling, Li, Nan, Han, Yanxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268050/
https://www.ncbi.nlm.nih.gov/pubmed/22252500
http://dx.doi.org/10.3390/molecules17010843
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author Zhang, Hui
Guo, Zengjun
Wu, Nan
Xu, Wenming
Han, Ling
Li, Nan
Han, Yanxia
author_facet Zhang, Hui
Guo, Zengjun
Wu, Nan
Xu, Wenming
Han, Ling
Li, Nan
Han, Yanxia
author_sort Zhang, Hui
collection PubMed
description An ethyl acetate extract of the roots of Rumex dentatus L. was investigated. Three compounds were identified by their spectroscopic data as chrysophanol (1), 6-methyl-7-acetyl-1, 8-dihydroxy-3-methoxy naphthalene-1-O-β-D(L)-glucoside (2) and 6-methyl-7-acetyl-1, 8-dihydroxy naphthalene-1-O-β-D(L)-glucoside (3) were found in the plant for the first time. Compounds 2 and 3 are novel compounds. Their antiproliferation activities were tested by the MTT assay in four cell lines (breast cancer MCF-7, gastric cancer 7901, melanoma A375 and oophoroma SKOV-3).
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spelling pubmed-62680502018-12-11 Two Novel Naphthalene Glucosides and an Anthraquinone Isolated from Rumex dentatus and Their Antiproliferation Activities in Four Cell Lines Zhang, Hui Guo, Zengjun Wu, Nan Xu, Wenming Han, Ling Li, Nan Han, Yanxia Molecules Article An ethyl acetate extract of the roots of Rumex dentatus L. was investigated. Three compounds were identified by their spectroscopic data as chrysophanol (1), 6-methyl-7-acetyl-1, 8-dihydroxy-3-methoxy naphthalene-1-O-β-D(L)-glucoside (2) and 6-methyl-7-acetyl-1, 8-dihydroxy naphthalene-1-O-β-D(L)-glucoside (3) were found in the plant for the first time. Compounds 2 and 3 are novel compounds. Their antiproliferation activities were tested by the MTT assay in four cell lines (breast cancer MCF-7, gastric cancer 7901, melanoma A375 and oophoroma SKOV-3). MDPI 2012-01-17 /pmc/articles/PMC6268050/ /pubmed/22252500 http://dx.doi.org/10.3390/molecules17010843 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zhang, Hui
Guo, Zengjun
Wu, Nan
Xu, Wenming
Han, Ling
Li, Nan
Han, Yanxia
Two Novel Naphthalene Glucosides and an Anthraquinone Isolated from Rumex dentatus and Their Antiproliferation Activities in Four Cell Lines
title Two Novel Naphthalene Glucosides and an Anthraquinone Isolated from Rumex dentatus and Their Antiproliferation Activities in Four Cell Lines
title_full Two Novel Naphthalene Glucosides and an Anthraquinone Isolated from Rumex dentatus and Their Antiproliferation Activities in Four Cell Lines
title_fullStr Two Novel Naphthalene Glucosides and an Anthraquinone Isolated from Rumex dentatus and Their Antiproliferation Activities in Four Cell Lines
title_full_unstemmed Two Novel Naphthalene Glucosides and an Anthraquinone Isolated from Rumex dentatus and Their Antiproliferation Activities in Four Cell Lines
title_short Two Novel Naphthalene Glucosides and an Anthraquinone Isolated from Rumex dentatus and Their Antiproliferation Activities in Four Cell Lines
title_sort two novel naphthalene glucosides and an anthraquinone isolated from rumex dentatus and their antiproliferation activities in four cell lines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268050/
https://www.ncbi.nlm.nih.gov/pubmed/22252500
http://dx.doi.org/10.3390/molecules17010843
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