Synthesis and Antiradical/Antioxidant Activities of Caffeic Acid Phenethyl Ester and Its Related Propionic, Acetic, and Benzoic Acid Analogues

Caffeic acid phenethyl ester (CAPE) is a bioactive component isolated from propolis. A series of CAPE analogues was synthesized and their antiradical/antioxidant effects analyzed. The effect of the presence of the double bond and of the conjugated system on the antioxidant effect is evaluated with t...

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Autores principales: LeBlanc, Luc M., Paré, Aurélie F., Jean-François, Jacques, Hébert, Martin J. G., Surette, Marc E., Touaibia, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268051/
https://www.ncbi.nlm.nih.gov/pubmed/23222926
http://dx.doi.org/10.3390/molecules171214637
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author LeBlanc, Luc M.
Paré, Aurélie F.
Jean-François, Jacques
Hébert, Martin J. G.
Surette, Marc E.
Touaibia, Mohamed
author_facet LeBlanc, Luc M.
Paré, Aurélie F.
Jean-François, Jacques
Hébert, Martin J. G.
Surette, Marc E.
Touaibia, Mohamed
author_sort LeBlanc, Luc M.
collection PubMed
description Caffeic acid phenethyl ester (CAPE) is a bioactive component isolated from propolis. A series of CAPE analogues was synthesized and their antiradical/antioxidant effects analyzed. The effect of the presence of the double bond and of the conjugated system on the antioxidant effect is evaluated with the analogues obtained from 3-(3,4-dihydroxyphenyl) propanoic acid. Those obtained from 2-(3,4-dihydroxyphenyl) acetic acid and 3,4-dihydroxybenzoic acid allow the evaluation of the effect of the presence of two carbons between the carbonyl and aromatic system.
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spelling pubmed-62680512018-12-14 Synthesis and Antiradical/Antioxidant Activities of Caffeic Acid Phenethyl Ester and Its Related Propionic, Acetic, and Benzoic Acid Analogues LeBlanc, Luc M. Paré, Aurélie F. Jean-François, Jacques Hébert, Martin J. G. Surette, Marc E. Touaibia, Mohamed Molecules Article Caffeic acid phenethyl ester (CAPE) is a bioactive component isolated from propolis. A series of CAPE analogues was synthesized and their antiradical/antioxidant effects analyzed. The effect of the presence of the double bond and of the conjugated system on the antioxidant effect is evaluated with the analogues obtained from 3-(3,4-dihydroxyphenyl) propanoic acid. Those obtained from 2-(3,4-dihydroxyphenyl) acetic acid and 3,4-dihydroxybenzoic acid allow the evaluation of the effect of the presence of two carbons between the carbonyl and aromatic system. MDPI 2012-12-10 /pmc/articles/PMC6268051/ /pubmed/23222926 http://dx.doi.org/10.3390/molecules171214637 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
LeBlanc, Luc M.
Paré, Aurélie F.
Jean-François, Jacques
Hébert, Martin J. G.
Surette, Marc E.
Touaibia, Mohamed
Synthesis and Antiradical/Antioxidant Activities of Caffeic Acid Phenethyl Ester and Its Related Propionic, Acetic, and Benzoic Acid Analogues
title Synthesis and Antiradical/Antioxidant Activities of Caffeic Acid Phenethyl Ester and Its Related Propionic, Acetic, and Benzoic Acid Analogues
title_full Synthesis and Antiradical/Antioxidant Activities of Caffeic Acid Phenethyl Ester and Its Related Propionic, Acetic, and Benzoic Acid Analogues
title_fullStr Synthesis and Antiradical/Antioxidant Activities of Caffeic Acid Phenethyl Ester and Its Related Propionic, Acetic, and Benzoic Acid Analogues
title_full_unstemmed Synthesis and Antiradical/Antioxidant Activities of Caffeic Acid Phenethyl Ester and Its Related Propionic, Acetic, and Benzoic Acid Analogues
title_short Synthesis and Antiradical/Antioxidant Activities of Caffeic Acid Phenethyl Ester and Its Related Propionic, Acetic, and Benzoic Acid Analogues
title_sort synthesis and antiradical/antioxidant activities of caffeic acid phenethyl ester and its related propionic, acetic, and benzoic acid analogues
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268051/
https://www.ncbi.nlm.nih.gov/pubmed/23222926
http://dx.doi.org/10.3390/molecules171214637
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