Secondary Metabolites from Two Species of Tolpis and Their Biological Activities

Phytochemical research of two Tolpis species, T. proustii and T. lagopoda, led to the isolation of three new compounds: 30-chloro-3β-acetoxy-22α-hydroxyl-20(21)-taraxastene (1), 3β,22α-diacetoxy-30-ethoxy-20(21)-taraxastene (2) and 3β,28-dihydroxy-11α-hydroperoxy-12-ursene (3). The structures of the...

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Autores principales: Triana, Jorge, López, Mariana, Pérez, Francisco Javier, Rico, Milagros, López, Aroa, Estévez, Francisco, Marrero, María Teresa, Brouard, Ignacio, León, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268065/
https://www.ncbi.nlm.nih.gov/pubmed/23117430
http://dx.doi.org/10.3390/molecules171112895
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author Triana, Jorge
López, Mariana
Pérez, Francisco Javier
Rico, Milagros
López, Aroa
Estévez, Francisco
Marrero, María Teresa
Brouard, Ignacio
León, Francisco
author_facet Triana, Jorge
López, Mariana
Pérez, Francisco Javier
Rico, Milagros
López, Aroa
Estévez, Francisco
Marrero, María Teresa
Brouard, Ignacio
León, Francisco
author_sort Triana, Jorge
collection PubMed
description Phytochemical research of two Tolpis species, T. proustii and T. lagopoda, led to the isolation of three new compounds: 30-chloro-3β-acetoxy-22α-hydroxyl-20(21)-taraxastene (1), 3β,22α-diacetoxy-30-ethoxy-20(21)-taraxastene (2) and 3β,28-dihydroxy-11α-hydroperoxy-12-ursene (3). The structures of the new compounds were elucidated by means of extensive IR, NMR, and MS data and by comparison of data reported in the literature. The in vitro antioxidant activities of the extracts were assessed by the DPPH and ABTS scavenging methods. The cytotoxicity of several known compounds and its derivatives was also assessed against human myeloid leukemia K-562 and K-562/ADR cell lines.
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spelling pubmed-62680652018-12-13 Secondary Metabolites from Two Species of Tolpis and Their Biological Activities Triana, Jorge López, Mariana Pérez, Francisco Javier Rico, Milagros López, Aroa Estévez, Francisco Marrero, María Teresa Brouard, Ignacio León, Francisco Molecules Article Phytochemical research of two Tolpis species, T. proustii and T. lagopoda, led to the isolation of three new compounds: 30-chloro-3β-acetoxy-22α-hydroxyl-20(21)-taraxastene (1), 3β,22α-diacetoxy-30-ethoxy-20(21)-taraxastene (2) and 3β,28-dihydroxy-11α-hydroperoxy-12-ursene (3). The structures of the new compounds were elucidated by means of extensive IR, NMR, and MS data and by comparison of data reported in the literature. The in vitro antioxidant activities of the extracts were assessed by the DPPH and ABTS scavenging methods. The cytotoxicity of several known compounds and its derivatives was also assessed against human myeloid leukemia K-562 and K-562/ADR cell lines. MDPI 2012-11-01 /pmc/articles/PMC6268065/ /pubmed/23117430 http://dx.doi.org/10.3390/molecules171112895 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Triana, Jorge
López, Mariana
Pérez, Francisco Javier
Rico, Milagros
López, Aroa
Estévez, Francisco
Marrero, María Teresa
Brouard, Ignacio
León, Francisco
Secondary Metabolites from Two Species of Tolpis and Their Biological Activities
title Secondary Metabolites from Two Species of Tolpis and Their Biological Activities
title_full Secondary Metabolites from Two Species of Tolpis and Their Biological Activities
title_fullStr Secondary Metabolites from Two Species of Tolpis and Their Biological Activities
title_full_unstemmed Secondary Metabolites from Two Species of Tolpis and Their Biological Activities
title_short Secondary Metabolites from Two Species of Tolpis and Their Biological Activities
title_sort secondary metabolites from two species of tolpis and their biological activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268065/
https://www.ncbi.nlm.nih.gov/pubmed/23117430
http://dx.doi.org/10.3390/molecules171112895
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