α-Glucosidase Inhibitory Constituents from Acanthopanax senticosus Harm Leaves

A new triterpene glycoside, 3-O-[(α-L-rhamnopyranosyl)(1→2)]-[β-D-glucuronopyranosyl-6-O-methyl ester]-olean-12-ene-28-olic acid (1) and a new indole alkaloid, 5-methoxy-2-oxoindolin-3-acetic acid methyl ester (5) were isolated from the leaves of Acanthopanax senticosus Harms along with six known co...

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Autores principales: Wang, Zhi-Bin, Jiang, Hai, Xia, Yong-Gang, Yang, Bing-You, Kuang, Hai-Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268071/
https://www.ncbi.nlm.nih.gov/pubmed/22634838
http://dx.doi.org/10.3390/molecules17066269
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author Wang, Zhi-Bin
Jiang, Hai
Xia, Yong-Gang
Yang, Bing-You
Kuang, Hai-Xue
author_facet Wang, Zhi-Bin
Jiang, Hai
Xia, Yong-Gang
Yang, Bing-You
Kuang, Hai-Xue
author_sort Wang, Zhi-Bin
collection PubMed
description A new triterpene glycoside, 3-O-[(α-L-rhamnopyranosyl)(1→2)]-[β-D-glucuronopyranosyl-6-O-methyl ester]-olean-12-ene-28-olic acid (1) and a new indole alkaloid, 5-methoxy-2-oxoindolin-3-acetic acid methyl ester (5) were isolated from the leaves of Acanthopanax senticosus Harms along with six known compounds. The structures of the new compounds were determined by means of 2D-NMR experiments and chemical methods. All the isolated compounds were evaluated for their glycosidase inhibition activities and compound 6 showed significant α-glucosidase inhibition activity.
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spelling pubmed-62680712018-12-12 α-Glucosidase Inhibitory Constituents from Acanthopanax senticosus Harm Leaves Wang, Zhi-Bin Jiang, Hai Xia, Yong-Gang Yang, Bing-You Kuang, Hai-Xue Molecules Article A new triterpene glycoside, 3-O-[(α-L-rhamnopyranosyl)(1→2)]-[β-D-glucuronopyranosyl-6-O-methyl ester]-olean-12-ene-28-olic acid (1) and a new indole alkaloid, 5-methoxy-2-oxoindolin-3-acetic acid methyl ester (5) were isolated from the leaves of Acanthopanax senticosus Harms along with six known compounds. The structures of the new compounds were determined by means of 2D-NMR experiments and chemical methods. All the isolated compounds were evaluated for their glycosidase inhibition activities and compound 6 showed significant α-glucosidase inhibition activity. MDPI 2012-05-25 /pmc/articles/PMC6268071/ /pubmed/22634838 http://dx.doi.org/10.3390/molecules17066269 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wang, Zhi-Bin
Jiang, Hai
Xia, Yong-Gang
Yang, Bing-You
Kuang, Hai-Xue
α-Glucosidase Inhibitory Constituents from Acanthopanax senticosus Harm Leaves
title α-Glucosidase Inhibitory Constituents from Acanthopanax senticosus Harm Leaves
title_full α-Glucosidase Inhibitory Constituents from Acanthopanax senticosus Harm Leaves
title_fullStr α-Glucosidase Inhibitory Constituents from Acanthopanax senticosus Harm Leaves
title_full_unstemmed α-Glucosidase Inhibitory Constituents from Acanthopanax senticosus Harm Leaves
title_short α-Glucosidase Inhibitory Constituents from Acanthopanax senticosus Harm Leaves
title_sort α-glucosidase inhibitory constituents from acanthopanax senticosus harm leaves
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268071/
https://www.ncbi.nlm.nih.gov/pubmed/22634838
http://dx.doi.org/10.3390/molecules17066269
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