Synthesis and Biological Evaluation of 3-Aryl-quinoxaline-2-carbonitrile 1,4-Di-N-oxide Derivatives as Hypoxic Selective Anti-tumor Agents

A series of 3-aryl-2-quinoxaline-carbonitrile 1,4-di-N-oxide derivatives were designed, synthesized and evaluated for hypoxic and normoxic cytotoxic activity against human SMMC-7721, K562, KB, A549 and PC-3 cell lines. Many of these new compounds displayed more potent hypoxic cytotoxic activity comp...

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Detalles Bibliográficos
Autores principales: Hu, Yunzhen, Xia, Qing, Shangguan, Shihao, Liu, Xiaowen, Hu, Yongzhou, Sheng, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268107/
https://www.ncbi.nlm.nih.gov/pubmed/22890172
http://dx.doi.org/10.3390/molecules17089683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268107/
https://www.ncbi.nlm.nih.gov/pubmed/22890172
http://dx.doi.org/10.3390/molecules17089683

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