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Microwave-assisted Solvent-free Synthesis and in Vitro Antibacterial Screening of Quinoxalines and Pyrido[2, 3b]pyrazines
We report herein the microwave assisted synthesis, without solvents and catalysts, of 6-substituted quinoxalines and 7-substituted pyrido[2,3b]pyrazines. The compounds were obtained in good yields and short reaction times using the mentioned procedure and two new structures are reported. A complete...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268137/ https://www.ncbi.nlm.nih.gov/pubmed/22628038 http://dx.doi.org/10.3390/molecules17055164 |
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author | Morales-Castellanos, J. Jesús Ramírez-Hernández, Karina Gómez-Flores, Nancy S. Rodas-Suárez, Oscar R. Peralta-Cruz, Javier |
author_facet | Morales-Castellanos, J. Jesús Ramírez-Hernández, Karina Gómez-Flores, Nancy S. Rodas-Suárez, Oscar R. Peralta-Cruz, Javier |
author_sort | Morales-Castellanos, J. Jesús |
collection | PubMed |
description | We report herein the microwave assisted synthesis, without solvents and catalysts, of 6-substituted quinoxalines and 7-substituted pyrido[2,3b]pyrazines. The compounds were obtained in good yields and short reaction times using the mentioned procedure and two new structures are reported. A complete (1)H- and (13)C-NMR assignment was performed using 1D and 2D-NMR. Additionally, an in vitro screening was performed on Gram-positive and Gram-negative bacteria using amoxicillin as positive reference. Compounds bearing a pyridyl group tended to have higher antibacterial activity, but the best activity against Bacillus subtilis and Proteus mirabilis was observed with quinoxaline derivatives. |
format | Online Article Text |
id | pubmed-6268137 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62681372018-12-20 Microwave-assisted Solvent-free Synthesis and in Vitro Antibacterial Screening of Quinoxalines and Pyrido[2, 3b]pyrazines Morales-Castellanos, J. Jesús Ramírez-Hernández, Karina Gómez-Flores, Nancy S. Rodas-Suárez, Oscar R. Peralta-Cruz, Javier Molecules Article We report herein the microwave assisted synthesis, without solvents and catalysts, of 6-substituted quinoxalines and 7-substituted pyrido[2,3b]pyrazines. The compounds were obtained in good yields and short reaction times using the mentioned procedure and two new structures are reported. A complete (1)H- and (13)C-NMR assignment was performed using 1D and 2D-NMR. Additionally, an in vitro screening was performed on Gram-positive and Gram-negative bacteria using amoxicillin as positive reference. Compounds bearing a pyridyl group tended to have higher antibacterial activity, but the best activity against Bacillus subtilis and Proteus mirabilis was observed with quinoxaline derivatives. MDPI 2012-05-04 /pmc/articles/PMC6268137/ /pubmed/22628038 http://dx.doi.org/10.3390/molecules17055164 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Morales-Castellanos, J. Jesús Ramírez-Hernández, Karina Gómez-Flores, Nancy S. Rodas-Suárez, Oscar R. Peralta-Cruz, Javier Microwave-assisted Solvent-free Synthesis and in Vitro Antibacterial Screening of Quinoxalines and Pyrido[2, 3b]pyrazines |
title | Microwave-assisted Solvent-free Synthesis and in Vitro Antibacterial Screening of Quinoxalines and Pyrido[2, 3b]pyrazines |
title_full | Microwave-assisted Solvent-free Synthesis and in Vitro Antibacterial Screening of Quinoxalines and Pyrido[2, 3b]pyrazines |
title_fullStr | Microwave-assisted Solvent-free Synthesis and in Vitro Antibacterial Screening of Quinoxalines and Pyrido[2, 3b]pyrazines |
title_full_unstemmed | Microwave-assisted Solvent-free Synthesis and in Vitro Antibacterial Screening of Quinoxalines and Pyrido[2, 3b]pyrazines |
title_short | Microwave-assisted Solvent-free Synthesis and in Vitro Antibacterial Screening of Quinoxalines and Pyrido[2, 3b]pyrazines |
title_sort | microwave-assisted solvent-free synthesis and in vitro antibacterial screening of quinoxalines and pyrido[2, 3b]pyrazines |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268137/ https://www.ncbi.nlm.nih.gov/pubmed/22628038 http://dx.doi.org/10.3390/molecules17055164 |
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