A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones

A newly found reaction for the synthesis of 3,4-disubstituted 1-hydroxy-pyrrolidine-2,5-diones from 3-substituted coumarins and nitromethane has been elaborated. The reaction involved a simple and convenient experimental procedure. The applicability of the rearrangement reaction is determined.

Detalles Bibliográficos
Autores principales: Ilieva, Eleonora D., Petkova, Nevena I., Nikolova, Rositca D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268139/
https://www.ncbi.nlm.nih.gov/pubmed/22547316
http://dx.doi.org/10.3390/molecules17054936
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author Ilieva, Eleonora D.
Petkova, Nevena I.
Nikolova, Rositca D.
author_facet Ilieva, Eleonora D.
Petkova, Nevena I.
Nikolova, Rositca D.
author_sort Ilieva, Eleonora D.
collection PubMed
description A newly found reaction for the synthesis of 3,4-disubstituted 1-hydroxy-pyrrolidine-2,5-diones from 3-substituted coumarins and nitromethane has been elaborated. The reaction involved a simple and convenient experimental procedure. The applicability of the rearrangement reaction is determined.
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spelling pubmed-62681392018-12-20 A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones Ilieva, Eleonora D. Petkova, Nevena I. Nikolova, Rositca D. Molecules Article A newly found reaction for the synthesis of 3,4-disubstituted 1-hydroxy-pyrrolidine-2,5-diones from 3-substituted coumarins and nitromethane has been elaborated. The reaction involved a simple and convenient experimental procedure. The applicability of the rearrangement reaction is determined. MDPI 2012-04-30 /pmc/articles/PMC6268139/ /pubmed/22547316 http://dx.doi.org/10.3390/molecules17054936 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Ilieva, Eleonora D.
Petkova, Nevena I.
Nikolova, Rositca D.
A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones
title A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones
title_full A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones
title_fullStr A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones
title_full_unstemmed A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones
title_short A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones
title_sort new and efficient method for the synthesis of 3,4-disubstituted pyrrolidine-2,5-diones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268139/
https://www.ncbi.nlm.nih.gov/pubmed/22547316
http://dx.doi.org/10.3390/molecules17054936
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