Chemical Genetics: Budding Yeast as a Platform for Drug Discovery and Mapping of Genetic Pathways

The budding yeast Saccharomyces cerevisiae is a widely used model organism, and yeast genetic methods are powerful tools for discovery of novel functions of genes. Recent advancements in chemical-genetics and chemical-genomics have opened new avenues for development of clinically relevant drug treat...

Descripción completa

Detalles Bibliográficos
Autor principal: Enserink, Jorrit M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268143/
https://www.ncbi.nlm.nih.gov/pubmed/22858845
http://dx.doi.org/10.3390/molecules17089258
_version_ 1783376221489332224
author Enserink, Jorrit M.
author_facet Enserink, Jorrit M.
author_sort Enserink, Jorrit M.
collection PubMed
description The budding yeast Saccharomyces cerevisiae is a widely used model organism, and yeast genetic methods are powerful tools for discovery of novel functions of genes. Recent advancements in chemical-genetics and chemical-genomics have opened new avenues for development of clinically relevant drug treatments. Systematic mapping of genetic networks by high-throughput chemical-genetic screens have given extensive insight in connections between genetic pathways. Here, I review some of the recent developments in chemical-genetic techniques in budding yeast.
format Online
Article
Text
id pubmed-6268143
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62681432018-12-12 Chemical Genetics: Budding Yeast as a Platform for Drug Discovery and Mapping of Genetic Pathways Enserink, Jorrit M. Molecules Review The budding yeast Saccharomyces cerevisiae is a widely used model organism, and yeast genetic methods are powerful tools for discovery of novel functions of genes. Recent advancements in chemical-genetics and chemical-genomics have opened new avenues for development of clinically relevant drug treatments. Systematic mapping of genetic networks by high-throughput chemical-genetic screens have given extensive insight in connections between genetic pathways. Here, I review some of the recent developments in chemical-genetic techniques in budding yeast. MDPI 2012-08-02 /pmc/articles/PMC6268143/ /pubmed/22858845 http://dx.doi.org/10.3390/molecules17089258 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Enserink, Jorrit M.
Chemical Genetics: Budding Yeast as a Platform for Drug Discovery and Mapping of Genetic Pathways
title Chemical Genetics: Budding Yeast as a Platform for Drug Discovery and Mapping of Genetic Pathways
title_full Chemical Genetics: Budding Yeast as a Platform for Drug Discovery and Mapping of Genetic Pathways
title_fullStr Chemical Genetics: Budding Yeast as a Platform for Drug Discovery and Mapping of Genetic Pathways
title_full_unstemmed Chemical Genetics: Budding Yeast as a Platform for Drug Discovery and Mapping of Genetic Pathways
title_short Chemical Genetics: Budding Yeast as a Platform for Drug Discovery and Mapping of Genetic Pathways
title_sort chemical genetics: budding yeast as a platform for drug discovery and mapping of genetic pathways
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268143/
https://www.ncbi.nlm.nih.gov/pubmed/22858845
http://dx.doi.org/10.3390/molecules17089258
work_keys_str_mv AT enserinkjorritm chemicalgeneticsbuddingyeastasaplatformfordrugdiscoveryandmappingofgeneticpathways

Ejemplares similares